Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies

Autor: Pons, D., Trompet, S., Craen, A.J.M. de, Thijssen, P.E., Quax, P.H.A., Vries, M.R. de, Wierda, R.J., Elsen, P.J. van den, Monraats, P.S., Ewing, M.M., Heijmans, B.T., Slagboom, P.E., Zwinderman, A.H., Doevendans, P.A.F.M., Tio, R.A., Winter, R.J. de, Maat, M.P.M. de, Iakoubova, O.A., Sattar, N., Shepherd, J., Westendorp, R.G.J., Jukema, J.W., PROSPER Study Grp, WOSCOPS Study Grp, GENDER Study Grp

Publikováno v: Heart (British Cardiac Society), 97(2), 143-150. BMJ Publishing Group
Pons, D, Trompet, S, Craen, A J M, Thijssen, P E, Quax, P H A, de Vries, M R, Wierda, R J, van den Elsen, P J, Monraats, P S, Ewing, M M, Heijmans, B T, Slagboom, P E, Zwinderman, A H, Doevendans, P A F M, Tio, R A, de Winter, R J, de Maat, M P M, Lakoubova, O A, Sattar, N, Sheperd, J, Westendorp, R G J & Jukema, J W 2011, ' Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies ', Heart, vol. 97, no. 2, pp. 143-150 . https://doi.org/10.1136/hrt.2010.199927
Heart
Heart, 97(2), 143-150. BMJ Publishing Group
Heart, 97(2), 143-150. BMJ PUBLISHING GROUP
Heart, 97(2), 143-150

Aims This study was designed to investigate the counterbalancing influence of genetic variation in the promoter of the gene encoding P300/CBP associated factor (PCAF), a lysine acetyltransferase (KAT), on coronary heart disease (CHD) and mortality.Me

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https://pure.amc.nl/en/publications/genetic-variation-in-pcaf-a-key-mediator-in-epigenetics-is-associated-with-reduced-vascular-morbidity-and-mortality-evidence-for-a-new-concept-from-three-independent-prospective-studies(afb1b39d-8d5a-4265-bd29-0bf1c8855b0c).html

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