Zobrazeno 1 - 10
of 2 900
pro vyhledávání: '"WNT/β‐catenin pathway"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Purpose Intestinal flora promotes the pathogenesis of colorectal cancer (CRC) through microorganisms and their metabolites. This study aimed to investigate the composition of intestinal flora in different stages of CRC progression and the ef
Externí odkaz:
https://doaj.org/article/9755ddf2e73b4bf4865ae5ac6d0d3118
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Esophageal cancer (EC) poses a substantial threat to human health. The development of radioresistance in esophageal cancer cells is a critical factor contributing to local treatment failure and an unfavorable prognosis in affected patients.
Externí odkaz:
https://doaj.org/article/c891d02fce524d2b8c5c679dbca67edc
Autor:
You-li Tan, Shao-hua Ju, Qiang Wang, Rui Zhong, Ji-hai Gao, Ming-jian Wang, Ya-lan Kang, Meng-zhang Xu
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract This study aimed to investigate the effects of Shuanglongjiegu pill (SLJGP) on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and explore its mechanism based on miR-217/RUNX2 axis. Results found that drug-contai
Externí odkaz:
https://doaj.org/article/33fb09ee72294a81bb2971a39f054adb
Autor:
Shi-Hua Wang, Shi-Rui Wang, Na-Na Luan, Xiao-Qian Sun, Yi-Ran Guo, Ying-Bin Yan, Su-Xia Liang
Publikováno v:
Journal of Dental Sciences, Vol 19, Iss 4, Pp 2090-2099 (2024)
Background/purpose: Dental pulp stem cells (DPSCs) have demonstrated significant potential for neuroregeneration. However, a full understanding of the specific mechanism underpinning the neural differentiation of DPSCs is still required. The Wnt sign
Externí odkaz:
https://doaj.org/article/5db5ab77939a403eb08d3d1b358d94fd
Autor:
Yang Shen, Jiayu Chen, Zhuolin Zhou, Jingyu Wu, Xinyao Hu, Yangtao Xu, Jiayi Li, Ling Wang, Siyu Wang, Shuhong Yu, Ling Feng, Ximing Xu
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-19 (2024)
Abstract Background In hepatocellular carcinoma (HCC) treatment, first-line targeted therapy in combination with immune checkpoint inhibitors (ICIs) has improved patient prognosis, but the 5-year survival rate is far from satisfactory. Studies have s
Externí odkaz:
https://doaj.org/article/79451d7af2d6417692184e0da9fb96bc
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background The established association between Alzheimer's disease (AD) and compromised neural regeneration is well-documented. In addition to the mitigation of apoptosis in neural stem cells (NSCs), the induction of neurogenesis has been pr
Externí odkaz:
https://doaj.org/article/509fe601a6e7470b9ea8a790c186aa8e
Publikováno v:
Cell Division, Vol 19, Iss 1, Pp 1-12 (2024)
Abstract Background Nuclear-enriched abundant transcript 1 (NEAT1), a long noncoding RNA (lncRNA), has been implicated in the colorectal cancer (CRC) progression. However, its upstream mechanism has not been well studied. In the present study, the fu
Externí odkaz:
https://doaj.org/article/c4b267643af3463b8aff9de76e2af49d
Autor:
Dilara Akhoundova, Stefanie Fischer, Joanna Triscott, Marika Lehner, Phillip Thienger, Sina Maletti, Muriel Jacquet, Dinda S.H. Lubis, Lukas Bubendorf, Wolfram Jochum, Mark A. Rubin
Publikováno v:
Diagnostic Pathology, Vol 19, Iss 1, Pp 1-10 (2024)
Abstract Background Catenin (Cadherin-Associated Protein), Beta 1 (CTNNB1) genomic alterations are rare in prostate cancer (PCa). Gain-of-function mutations lead to overexpression of β-catenin, with consequent hyperactivation of the Wnt/β-catenin s
Externí odkaz:
https://doaj.org/article/ab8d7da124964dd89f2c5fdc280d36be
Autor:
Ni Liu, Qi Zheng, Yuqing Zhang, Huimin Wang, Zhihui Zhang, Long He, Chenxi Wei, Handai Xia, Yanguo Liu, Xiuwen Wang
Publikováno v:
Thoracic Cancer, Vol 15, Iss 18, Pp 1419-1428 (2024)
Abstract Background Cancer stem cells (CSCs) are a specific subpopulation of cancer cells with the ability of self‐renewal, infinite proliferation, multidifferentiation and tumorigenicity, and play critical roles in cancer progression and treatment
Externí odkaz:
https://doaj.org/article/1acc071e2931417db50cee220a0c1f7e
Autor:
Qiongyin Zhang, Ning An, Yang Liu, Ying Zhu, Wuliang Pan, Peiling Gu, Jinzhu Zhao, Qiang Pu, Wen Zhu
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionSurfactant Protein C gene (SFTPC) is a marker gene of alveolar type 2 cells (AT2), which are the key structures of alveoli. Mutations or deletions in SFTPC cause idiopathic pulmonary fibrosis (IPF). Importantly, IPF is an independent risk
Externí odkaz:
https://doaj.org/article/ec51d7656a234797a5b38c45440a9015