Intracisternal administration of tanshinone IIA-loaded nanoparticles leads to reduced tissue injury and functional deficits in a porcine model of ischemic stroke

Autor: Xueyuan Yang, Soo K. Shin, Jin Xie, Kylee J. Duberstein, Madison M. Fagan, Simon R. Platt, Kelly M. Scheulin, Erin E. Kaiser, Holly A. Kinder, Elizabeth S. Waters, Julie Jeon, Franklin D. West, Anil Kumar, Hea Jin Park

Publikováno v: IBRO Neuroscience Reports
IBRO Neuroscience Reports, Vol 10, Iss, Pp 18-30 (2021)

Background The absolute number of new stroke patients is annually increasing and there still remains only a few Food and Drug Administration (FDA) approved treatments with significant limitations available to patients. Tanshinone IIA (Tan IIA) is a p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f797c86f00c6b2f76590c2d6fd382a6
http://europepmc.org/articles/PMC8019951

Estimation of diffusion, perfusion and fractional volumes using a multi-compartment relaxation-compensated intravoxel incoherent motion (IVIM) signal model

Autor: André Ahlgren, Linda Knutsson, Ofer Pasternak, Anna Rydhög, Ronnie Wirestam, Freddy Ståhlberg

Publikováno v: European Journal of Radiology Open
European Journal of Radiology Open, Vol 6, Iss, Pp 198-205 (2019)

Compartmental diffusion MRI models that account for intravoxel incoherent motion (IVIM) of blood perfusion allow for estimation of the fractional volume of the microvascular compartment. Conventional IVIM models are known to be biased by not accounti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75c82c0342e2a362b9ed7682f525c1e
http://europepmc.org/articles/PMC6538803

Patterns of grey and white matter changes differ between bulbar and limb onset amyotrophic lateral sclerosis

Autor: Robert, Steinbach, Tino, Prell, Nayana, Gaur, Annekathrin, Roediger, Christian, Gaser, Thomas E, Mayer, Otto W, Witte, Julian, Grosskreutz

Publikováno v: NeuroImage: Clinical, Vol 30, Iss, Pp 102674-(2021)
NeuroImage : Clinical

Highlights • Bulbar symptom onset shows more structural impairment than limb-onset in ALS. • Bulbar-onset ALS is characterized by an early and widespread cortical pathology. • Application of the D50 model enables comparability of heterogenous p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ccc80cd62776d9710260cac25fb6073b
http://www.sciencedirect.com/science/article/pii/S2213158221001182

Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study

Autor: Burggraaff, Jessica, Liu, Yao, Prieto, Juan C., Simoes, Jorge, de Sitter, Alexandra, Ruggieri, Serena, Brouwer, Iman, Lissenberg-Witte, Birgit I., Rocca, Mara A., Valsasina, Paola, Ropele, Stefan, Gasperini, Claudio, Gallo, Antonio, Pareto, Deborah, Sastre-Garriga, Jaume, Enzinger, Christian, Filippi, Massimo, De Stefano, Nicola, Ciccarelli, Olga, Hulst, Hanneke E., Wattjes, Mike P., Barkhof, Frederik, Uitdehaag, Bernard M. J., Vrenken, Hugo, Guttmann, Charles R. G., Universitat Autònoma de Barcelona

Publikováno v: NeuroImage: Clinical, 29:102549. Elsevier BV
Burggraaff, J, Liu, Y, Prieto, J C, Simoes, J, de Sitter, A, Ruggieri, S, Brouwer, I, Lissenberg-Witte, B I, Rocca, M A, Valsasina, P, Ropele, S, Gasperini, C, Gallo, A, Pareto, D, Sastre-Garriga, J, Enzinger, C, Filippi, M, de Stefano, N, Ciccarelli, O, Hulst, H E, Wattjes, M P, Barkhof, F, Uitdehaag, B M J, Vrenken, H & Guttmann, C R G 2021, ' Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study ', NeuroImage: Clinical, vol. 29, 102549 . https://doi.org/10.1016/j.nicl.2020.102549
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
NeuroImage : Clinical
NeuroImage. Clinical, Vol. 29, no. 1, p. 102549 [1-12] (2021)
Scientia
NeuroImage: Clinical, Vol 29, Iss, Pp 102549-(2021)

Highlights • Thalamus atrophy is associated with cognitive impairment in multiple sclerosis. • This was confirmed by automated and manual segmentations, but effect sizes varied. • The algorithms work in a multi-center setting. • Automated tec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4050b09dc6d0ff6de624197073c5fcda
https://doi.org/10.1016/j.nicl.2020.102549

Cortical glutamate and gamma-aminobutyric acid over the course of a provoked migraine attack, a 7 Tesla magnetic resonance spectroscopy study

Autor: Mark C. Kruit, Chloé Najac, Gisela M. Terwindt, Erik W. van Zwet, Michel D. Ferrari, Jannie P. Wijnen, Hermien E. Kan, Ronald Zielman, Robin M. van Dongen, Gerrit L J Onderwater, Itamar Ronen, Andrew G. Webb

Publikováno v: NeuroImage: Clinical, Vol 32, Iss, Pp 102889-(2021)
NeuroImage : Clinical
NeuroImage: Clinical, 32. ELSEVIER SCI LTD

Highlights • 7T MRS separately measured glutamate, glutamine and GABA towards triggered attacks. • Visual cortex GABA levels increased towards a preictal migraine state. • Visual cortex glutamate and glutamine levels were stable across migraine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38dd1790d54ec83a0ec6e1885bc4dfd5
https://hdl.handle.net/1887/3248782