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Asymptomatic primary biliary cirrhosis: clinical features, prognosis, and symptom progression in a large population based cohort

Autor: Jane Metcalf, Amanda G. Chetwynd, Oliver F. W. James, Martin Prince, WL Craig

Publikováno v: Gut. 53:865-870

Background: Many patients with primary biliary cirrhosis (PBC) are asymptomatic at the time of diagnosis. However, because most studies of asymptomatic PBC have been small and from tertiary centres, asymptomatic PBC remains poorly characterised. Aims

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c0ad77a37ce61fa02e06d8718907a6
https://doi.org/10.1136/gut.2003.023937

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HLA and interleukin 1 gene polymorphisms in primary biliary cirrhosis: associations with disease progression and disease susceptibility

Autor: A. Craggs, WL Craig, Peter T. Donaldson, D.E.J. Jones, Kosh Agarwal, Ofw James

Publikováno v: Gut. 48:397-402

BACKGROUND AND AIMS—Twin and family studies suggest that there is a genetic component to primary biliary cirrhosis (PBC) but the genetic associations which have been described are weak with marked variations between centres. PBC is heterogeneous an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ee3400af65d2de56a0cf1fabf12493
https://doi.org/10.1136/gut.48.3.397

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X inactivation patterns of closely, but not distantly, related cells are highly correlated: little evidence for stem cell plasticity in normal females

Autor: N. M. Masson, Mark A. Vickers, Sarah Jane Canning, WL Craig, Ian J. Wilson

Publikováno v: Stem cells (Dayton, Ohio). 24(11)

The early, random nature of X inactivation should cause related cells to have similar, but distinctive, active X chromosomes. We assessed the frequency of stem cell plasticity using X inactivation proportions (XIPs), determined at the human androgen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90237145e95a100f1afe1e58ee0b89d1
https://pubmed.ncbi.nlm.nih.gov/16825608

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Cellular turnover of normal gastrointestinal epithelium assessed by changes in telomeric: total DNA signal ratios

Autor: Mark A. Vickers, A. McKinlay, WL Craig

Publikováno v: European journal of gastroenterologyhepatology. 15(11)

Objectives The reasons why different areas of gastrointestinal mucosa exhibit widely different rates of malignant change are still poorly understood. Malignancy rates rise markedly with age. We therefore hypothesised that rates of malignant change mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c00c5e6a7604307b8caa1cea730260c
https://pubmed.ncbi.nlm.nih.gov/14560153

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Managing chronic hepatitis C acquired through intravenous drug use

Autor: M. Hewett, D. R. Bassendine, Alastair D. Burt, Margaret F. Bassendine, B. C. Smith, K Agarwal, Eilish Gilvarry, WL Craig, Sarah L. Jowett

Publikováno v: QJM : monthly journal of the Association of Physicians. 94(3)

We retrospectively reviewed the provision and uptake of hospital services for 253 current and ex‐intravenous drug users with hepatitis C virus (HCV). Overall, 237 attended at least one clinic (mean age 32 years, 70% male, 43% on maintenance methado

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e039db0967522f1b48c6d800b7fa598
https://pubmed.ncbi.nlm.nih.gov/11259690

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