DNA methylation and body mass index: investigating identified methylation sites at HIF3A in a causal framework

Autor: Rc, Richmond, Gemma Sharp, Me, Ward, Fraser A, Lyttleton O, Wl, Mcardle, Sm, Ring, Tr, Gaunt, Da, Lawlor, Gd, Smith, Cl, Relton

Publikováno v: Europe PubMed Central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::35a4eb194c359d7cd41d6de0042b707a
http://europepmc.org/abstract/med/26861784

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation.

Autor: Min JL; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. josine.min@bristol.ac.uk.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. josine.min@bristol.ac.uk., Hemani G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Hannon E; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK., Dekkers KF; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands., Castillo-Fernandez J; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Luijk R; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands., Carnero-Montoro E; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; Pfizer-University of Granada-Andalusian Government Center for Genomics and Oncological Research, Granada, Spain., Lawson DJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Burrows K; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Suderman M; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Bretherick AD; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Richardson TG; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Klughammer J; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Iotchkova V; MRC Weatherall Institute of Molecular Medicine, Oxford, UK., Sharp G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Al Khleifat A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London, UK., Shatunov A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London, UK., Iacoangeli A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London, UK.; Department of Biostatistics and Health Informatics, King's College London, London, UK., McArdle WL; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Ho KM; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Kumar A; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Chronic Disease Epidemiology unit, Swiss Tropical and Public Health Institute, Basel, Switzerland.; University of Basel, Basel, Switzerland., Söderhäll C; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden., Soriano-Tárraga C; Neurology Department, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain., Giralt-Steinhauer E; Neurology Department, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain., Kazmi N; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Mason D; Bradford Institute for Health Research, Bradford, UK., McRae AF; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia., Corcoran DL; Center for Genomic and Computational Biology, Duke University, Durham, NC, USA., Sugden K; Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA., Kasela S; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Cardona A; MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Department of Genetics, University of Cambridge, Cambridge, UK., Day FR; MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Cugliari G; Department of Medical Sciences, University of Turin, Turin, Italy.; Italian Institute for Genomic Medicine, Turin, Italy., Viberti C; Department of Medical Sciences, University of Turin, Turin, Italy.; Italian Institute for Genomic Medicine, Turin, Italy., Guarrera S; Department of Medical Sciences, University of Turin, Turin, Italy.; Italian Institute for Genomic Medicine, Turin, Italy., Lerro M; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada., Gupta R; Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.; Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Bollepalli S; Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.; Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Mandaviya P; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Zeng Y; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Faculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.; Guangdong Province Key Laboratory of Brain Function and Disease, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China., Clarke TK; Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK., Walker RM; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK., Schmoll V; Department of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany., Czamara D; Department of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany., Ruiz-Arenas C; ISGlobal, Barcelona Global Health Institute, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBER Epidemiología y Salud Pública, Madrid, Spain., Rezwan FI; Department of Computer Science, Aberystwyth University, Aberystwyth, UK., Marioni RE; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK., Lin T; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia., Awaloff Y; Department of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany., Germain M; INSERM UMR_S 1219, Bordeaux Population Health Center, University of Bordeaux, Bordeaux, France., Aïssi D; Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany., Zwamborn R; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands., van Eijk K; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands., Dekker A; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands., van Dongen J; Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Hottenga JJ; Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Willemsen G; Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Xu CJ; University of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, GRIAC Research Institute Groningen, Groningen, the Netherlands.; CiiM and TWINCORE, Hannover Medical School and Helmholtz Centre for Infection Research, Hannover, Germany., Barturen G; Pfizer-University of Granada-Andalusian Government Center for Genomics and Oncological Research, Granada, Spain., Català-Moll F; Chromatin and Disease Group, Cancer Epigenetics and Biology Programme, Bellvitge Biomedical Research Institute, Barcelona, Spain., Kerick M; Instituto de Parasitología y Biomedicina López Neyra, CSIC, Granada, Spain., Wang C; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, Australia., Melton P; Menzies Institute for Medical Research, College of Health and Medicine, University of Tasmania, Hobart, Australia.; School of Global Population Health, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Australia.; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin University, Perth, Australia., Elliott HR; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Shin J; The Hospital for Sick Children, University of Toronto, Toronto, Canada., Bernard M; The Hospital for Sick Children, University of Toronto, Toronto, Canada., Yet I; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.; Department of Bioinformatics, Institute of Health Sciences, Hacettepe University, Ankara, Turkey., Smart M; Institute for Social and Economic Research, University of Essex, Colchester, UK., Gorrie-Stone T; School of Life Sciences, University of Essex, Colchester, UK., Shaw C; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London, UK.; Department of Neurology, King's College Hospital, London, UK., Al Chalabi A; Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, London, UK.; Department of Neurology, King's College Hospital, London, UK.; United Kingdom Dementia Research Institute, King's College London, London, UK., Ring SM; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Pershagen G; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Melén E; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden., Jiménez-Conde J; Neurology Department, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain., Roquer J; Neurology Department, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain., Lawlor DA; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Wright J; Bradford Institute for Health Research, Bradford, UK., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Australia., Montgomery GW; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia., Moffitt TE; Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.; Department of Psychiatry and Behavioral Sciences, Duke University Medical School, Durham, NC, USA.; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Poulton R; Dunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand., Esko T; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Milani L; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Metspalu A; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia., Perry JRB; MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Ong KK; MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Wareham NJ; MRC Epidemiology Unit, School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Matullo G; Department of Medical Sciences, University of Turin, Turin, Italy.; Italian Institute for Genomic Medicine, Turin, Italy., Sacerdote C; Italian Institute for Genomic Medicine, Turin, Italy.; Piemonte Centre for Cancer Prevention, Turin, Italy., Panico S; Dipartimento Di Medicina Clinica E Chirurgia, Federico II University, Naples, Italy., Caspi A; Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.; Department of Psychology and Neuroscience, Duke University, Durham, NC, USA.; Department of Psychiatry and Behavioral Sciences, Duke University Medical School, Durham, NC, USA.; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Arseneault L; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Gagnon F; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada., Ollikainen M; Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.; Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Kaprio J; Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.; Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Felix JF; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Rivadeneira F; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Tiemeier H; Department of Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Social and Behavioral Science, Harvard TH Chan School of Public Health, Boston, MA, USA., van IJzendoorn MH; Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, the Netherlands.; Department of Clinical, Educational and Health Psychology, Division on Psychology and Language Sciences, Faculty of Brain Sciences, University College London, London, UK., Uitterlinden AG; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Jaddoe VWV; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Haley C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., McIntosh AM; Division of Psychiatry, Royal Edinburgh Hospital, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK., Evans KL; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK., Murray A; Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK., Räikkönen K; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Lahti J; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Nohr EA; Research Unit for Gynaecology and Obstetrics, Institute of Clinical research, University of Southern Denmark, Odense, Denmark.; Centre of Women's, Family and Child Health, University of South-Eastern Norway, Kongsberg, Norway., Sørensen TIA; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Public Health (Section of Epidemiology), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Morgen CS; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark., Binder EB; Department of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., Lucae S; Department of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany., Gonzalez JR; ISGlobal, Barcelona Global Health Institute, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBER Epidemiología y Salud Pública, Madrid, Spain., Bustamante M; ISGlobal, Barcelona Global Health Institute, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBER Epidemiología y Salud Pública, Madrid, Spain.; Center for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain., Sunyer J; ISGlobal, Barcelona Global Health Institute, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBER Epidemiología y Salud Pública, Madrid, Spain.; Hospital del Mar Medical Research Institute, Barcelona, Spain., Holloway JW; Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Karmaus W; Division of Epidemiology, Biostatistics, and Environmental Health Sciences, School of Public Health, University of Memphis, Memphis, TN, USA., Zhang H; Division of Epidemiology, Biostatistics, and Environmental Health Sciences, School of Public Health, University of Memphis, Memphis, TN, USA., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK., Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Australia., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK.; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK., Beekman M; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands., van Heemst D; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands., Slagboom PE; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands., Morange PE; C2VN, Aix-Marseille University, INSERM, INRAE, Marseille, France., Trégouët DA; INSERM UMR_S 1219, Bordeaux Population Health Center, University of Bordeaux, Bordeaux, France., Veldink JH; Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands., Davies GE; Avera Institute for Human Genetics, Sioux Falls, SD, USA., de Geus EJC; Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Boomsma DI; Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Vonk JM; University of Groningen, University Medical Center Groningen, Department of Epidemiology, GRIAC Research Institute Groningen, Groningen, the Netherlands., Brunekreef B; Institute for Risk Assessment Sciences, Universiteit Utrecht, Utrecht, the Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands., Koppelman GH; University of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, GRIAC Research Institute Groningen, Groningen, the Netherlands., Alarcón-Riquelme ME; Pfizer-University of Granada-Andalusian Government Center for Genomics and Oncological Research, Granada, Spain.; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Huang RC; Telethon Kids Institute, University of Western Australia, Perth, Australia., Pennell CE; School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, Australia., van Meurs J; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands., Ikram MA; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands., Hughes AD; UCL Institute of Cardiovascular Science, London, UK., Tillin T; UCL Institute of Cardiovascular Science, London, UK., Chaturvedi N; UCL Institute of Cardiovascular Science, London, UK., Pausova Z; The Hospital for Sick Children, University of Toronto, Toronto, Canada., Paus T; Departments of Psychology and Psychiatry, University of Toronto, Toronto, Canada., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Kumari M; Institute for Social and Economic Research, University of Essex, Colchester, UK., Schalkwyk LC; School of Life Sciences, University of Essex, Colchester, UK., Visscher PM; Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Australia., Davey Smith G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Bock C; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.; Institute of Artificial Intelligence and Decision Support, Center for Medical Statistics, Informatics, and Intelligent Systems, Medical University of Vienna, Vienna, Austria., Gaunt TR; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Bell JT; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Heijmans BT; Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands., Mill J; University of Exeter Medical School, College of Medicine and Health, University of Exeter, Exeter, UK., Relton CL; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Publikováno v: Nature genetics [Nat Genet] 2021 Sep; Vol. 53 (9), pp. 1311-1321. Date of Electronic Publication: 2021 Sep 06.

Identification of loci where DNA methylation potentially mediates genetic risk of type 1 diabetes.

Autor: Ye J; Diabetes and Metabolism, Bristol Medical School (Translational Health Sciences), University of Bristol, Level 2 Learning and Research, Southmead Hospital, Bristol, BS10 5NB, UK. Electronic address: jody.yi.ye@bristol.ac.uk., Richardson TG; MRC Integrative Epidemiology Unit, Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK., McArdle WL; Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK., Relton CL; MRC Integrative Epidemiology Unit, Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK., Gillespie KM; Diabetes and Metabolism, Bristol Medical School (Translational Health Sciences), University of Bristol, Level 2 Learning and Research, Southmead Hospital, Bristol, BS10 5NB, UK., Suderman M; MRC Integrative Epidemiology Unit, Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK., Hemani G; MRC Integrative Epidemiology Unit, Bristol Medical School (Population Health Sciences), University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.

Publikováno v: Journal of autoimmunity [J Autoimmun] 2018 Sep; Vol. 93, pp. 66-75. Date of Electronic Publication: 2018 Jun 29.

The epigenetic clock and physical development during childhood and adolescence: longitudinal analysis from a UK birth cohort.

Autor: Simpkin AJ; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK., Howe LD; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK., Tilling K; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK., Gaunt TR; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK., Lyttleton O; School of Social and Community Medicine, University of Bristol, Bristol, UK., McArdle WL; School of Social and Community Medicine, University of Bristol, Bristol, UK., Ring SM; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK., Horvath S; School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.; David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Smith GD; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK., Relton CL; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.

Publikováno v: International journal of epidemiology [Int J Epidemiol] 2017 Apr 01; Vol. 46 (2), pp. 549-558.

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.

Autor: Ried JS; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany., Jeff M J; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Chu AY; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA., Bragg-Gresham JL; Kidney Epidemiology and Cost Center, Internal Medicine-Nephrology, University of Michigan, Ann Arbor, Michigan 48109, USA., van Dongen J; Department of Biological Psychology, VU University, 1081BT Amsterdam, The Netherlands., Huffman JE; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU Edinburgh, Scotland., Ahluwalia TS; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark.; Steno Diabetes Center A/S, DK-2820 Gentofte, Denmark.; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Ledreborg Allé 34, DK-2820 Copenhagen, Denmark., Cadby G; Centre for Genetic Origins of Health and Disease, University of Western Australia, Crawley, Western Australia 6009, Australia., Eklund N; Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland., Eriksson J; Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden., Esko T; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 2142, USA.; Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA., Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63108, USA., Goel A; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Gorski M; Department of Nephrology, University Hospital Regensburg, 93042 Regensburg, Germany.; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, 93053 Regensburg, Germany., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU Edinburgh, Scotland., Heard-Costa NL; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.; Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA., Jackson AU; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Jokinen E; Hospital for Children and Adolescents, University of Helsinki, FI-00290 Helsinki, Finland., Kanoni S; Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Kristiansson K; Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.; Institute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland., Kutalik Z; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.; Department of Medical Genetics, University of Lausanne, Lausanne, 1005, Switzerland.; Institute of Social and Preventive Medicine, University Hospital Lausanne (CHUV), 1010 Lausanne, Switzerland., Lahti J; Folkhälsan Research Centre, FI-00290 Helsinki, Finland.; Institute of Behavioural Sciences, University of Helsinki, FI-00014 Helsinki, Finland., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Mägi R; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Medina-Gomez C; Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands., Monda KL; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.; The Center for Observational Research, Amgen Inc., Thousand Oaks, California 91320-1799, USA., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands., Pérusse L; Department of Kinesiology, Laval University, Québec, Québec, Canada G1V 0A6.; Institute of Nutrition and Functional Foods, Laval University, Québec, Québec, Canada G1V 0A6., Prokopenko I; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W12 0NN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK., Qi L; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA., Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA., Salvi E; Department of Health Sciences, University of Milano at San Paolo Hospital, 20139 Milano, Italy.; Filarete Foundation, Genomic and Bioinformatics Unit, Milano 20139, Italy., Smith MT; Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands., Stančáková A; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland., Ju Sung Y; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA., Tachmazidou I; Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK., Teumer A; Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany., Thorleifsson G; deCODE Genetics, Amgen inc., 101 Reykjavik, Iceland., van der Harst P; Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute, 3501 DG Utrecht, The Netherlands.; Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands., Walker RW; The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; The Department of Preventive Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Wang SR; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts 02115, USA.; Divisions of Genetics and Endocrinology and Program in Genomics, Boston's Children's Hospital, Boston, Massachusetts 02115, USA., Wild SH; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, EH8 9AG Teviot Place, Edinburgh, Scotland., Willems SM; Department of Epidemiology, Genetic Epidemiology Unit, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands., Wong A; MRC Unit for Lifelong Health &Ageing at UCL, London WC1B 5JU, UK., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK., Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany., Couto Alves A; Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London W12 0NN, UK., Bakker SJ; Department of Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands., Barlassina C; Department of Health Sciences, University of Milano at San Paolo Hospital, 20139 Milano, Italy.; Filarete Foundation, Genomic and Bioinformatics Unit, Milano 20139, Italy., Bartz TM; Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.; Department of Medicine, University of Washington, Seattle, Washington 98101, USA.; Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA., Beilby J; Pathwest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia.; School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia 6009, Australia., Bellis C; Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4001, Australia.; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research of Singapore, Singapore 138672, Singapore., Bergman RN; Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA., Bergmann S; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland.; Department of Medical Genetics, University of Lausanne, Lausanne, 1005, Switzerland., Blangero J; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Texas 78520, USA., Blüher M; University of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany.; Department of Medicine, University of Leipzig, 04103 Leipzig, Germany., Boerwinkle E; Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas 77030, USA., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Bornstein SR; Medical Faculty Carl Gustav Carus, Department of Medicine III, University of Dresden, 01307 Dresden, Germany., Bruinenberg M; University of Groningen, University Medical Center Groningen, The LifeLines Cohort Study, 9700 RB Groningen, The Netherlands., Campbell H; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, EH8 9AG Teviot Place, Edinburgh, Scotland., Chen YI; Los Angeles BioMedical Resesarch Institute at Harbor-UCLA Medical Center, Torrance, California 90502, USA., Chiang CW; Department of Psychiatry, University of California, Los Angeles, California 90095, USA., Chines PS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Collins FS; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Cucca F; University of Sassari, 07100 Sassari, Italy., Cupples LA; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA., D'Avila F; Department of Health Sciences, University of Milano at San Paolo Hospital, 20139 Milano, Italy.; Filarete Foundation, Genomic and Bioinformatics Unit, Milano 20139, Italy., de Geus EJ; Department of Biological Psychology, VU University, 1081BT Amsterdam, The Netherlands.; EMGO Institute for Health and Care Research, VU University Medical Center, 1081 BT Amsterdam, The Netherlands., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 17671 Athens, Greece., Dimitriou M; Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 17671 Athens, Greece., Döring A; Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany., Eriksson JG; Folkhälsan Research Centre, FI-00290 Helsinki, Finland.; Department of Chronic Disease Prevention, National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki, FI-00014 Helsinki, Finland., Farmaki AE; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 17671 Athens, Greece., Farrall M; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Ferreira T; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Fischer K; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Forouhi NG; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Friedrich N; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany., Gjesing AP; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark., Glorioso N; Hypertension and Related Disease Centre, AOU-University of Sassari, 7100 Sassari, Italy., Graff M; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Grallert H; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany., Grarup N; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark., Gräßler J; Department of Medicine III, Pathobiochemistry, Technische Universitaet, 01307 Dresden, Germany., Grewal J; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK., Hamsten A; Department of Medicine, Karolinska Institutet, Stockholm, Sweden.; Department of Medicine Solna, Atherosclerosis Research Unit, Karolinska Institutet, 17176 Stockholm 17176, Sweden.; Center for Molecular Medicine, Karolinska University Hospital, 17176 Stockholm, Sweden., Harder MN; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark., Hartman CA; University of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion Regulation, 9700 RB Groningen, The Netherlands., Hassinen M; Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland., Hastie N; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU Edinburgh, Scotland., Hattersley AT; Institue of Biomedical &Clinical Science, University of Exeter, Barrack Road, Exeter EX2 5DW, UK., Havulinna AS; Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland., Heliövaara M; Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland., Hillege H; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands., Hofman A; Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands., Holmen O; Department of Public Health and General Practice, Norwegian University of Science and Technology, 7489 Trondheim, Norway., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany., Hottenga JJ; Department of Biological Psychology, VU University, 1081BT Amsterdam, The Netherlands., Hui J; Pathwest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia.; School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia 6009, Australia.; School of Population Health, University of Western Australia, Nedlands, Western Australia 6009, Australia., Husemoen LL; Research Centre for Prevention and Health, Glostrup Hospital, 2600 Glostrup, Denmark., Hysi PG; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK., Isaacs A; Department of Epidemiology, Genetic Epidemiology Unit, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands., Ittermann T; Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany., Jalilzadeh S; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., James AL; Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia., Jørgensen T; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.; Faculty of Medicine, University of Aalborg, 9220 Aalborg, Denmark.; Research Centre for Prevention and Health, Capital Region of Denmark, DK2600 Glostrup, Denmark., Jousilahti P; Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland., Jula A; Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland., Marie Justesen J; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark., Justice AE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, FI-33521 Tampere, Finland.; Department of Clinical Physiology, University of Tampere School of Medicine, FI-33014 Tampere, Finland., Karaleftheri M; Echinos Medical Centre, 67300 Echinos, Greece., Tee Khaw K; Clinical Gerontology Unit, Box 251, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK., Keinanen-Kiukaanniemi SM; Faculty of Medicine, Institute of Health Sciences, University of Oulu, Oulu F1-90014, Finland.; Unit of General Practice, Oulu University Hospital, Oulu FI-90029, Finland., Kinnunen L; National Institute for Health and Welfare, FI-00271 Helsinki, Finland., Knekt PB; Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland., Koistinen HA; National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Department of Medicine and Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital,, 00029 Helsinki, Finland.; Minerva Foundation Institute for Medical Research, 00290 Helsinki, Finland., Kolcic I; Department of Public Health, Faculty of Medicine, University of Split, 21000 Split, Croatia., Kooner IK; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK., Koskinen S; Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland., Kovacs P; University of Leipzig, IFB Adiposity Diseases, 04103 Leipzig, Germany., Kyriakou T; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Laitinen T; Kuopio University Hospital, 70029 Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, University of Eastern Finland, FI-70211 Kuopio, Finland., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; Department of Epidemiology and Public Health, UCL, London WC1E 6BT, UK., Lewin AM; Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College, London W12 0NN, UK., Lichtner P; Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany., Lindgren CM; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 2142, USA.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; The Big Data Institute, University of Oxford, Oxford OX3 7LJ, UK., Lindström J; Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland., Linneberg A; Research Centre for Prevention and Health, Glostrup Hospital, 2600 Glostrup, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.; Department of Clinical Experimental Research, Rigshospitalet, 2600 Glostrup, Denmark., Lorbeer R; Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany., Lorentzon M; Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden., Luben R; Strangeways Research Laboratory Wort's Causeway, Cambridge CB1 8RN, UK., Lyssenko V; Steno Diabetes Center A/S, DK-2820 Gentofte, Denmark.; Lund University Diabetes Centre and Department of Clinical Science, Diabetes &Endocrinology Unit, Lund University, 221 00 Malmö, Sweden., Männistö S; Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland., Manunta P; Chair of Nephrology, Università Vita Salute San Raffaele and Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, Milan 20139, Italy., Leach IM; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands., McArdle WL; School of Social and Community Medicine, University of Bristol, Bristol BS82BN, UK., Mcknight B; Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.; Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98101, USA.; Divison of Public Health Sciences, Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Mihailov E; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Milani L; Estonian Genome Center, University of Tartu, Tartu 51010, Estonia., Mills R; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK., Montasser ME; Division of Endocrinology, Diabetes &Nutrition, Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA., Morris AP; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK., Müller G; Center for Evidence Based Healthcare, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, 01307, Germany., Musk AW; Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, West Australia 6009, Australia., Narisu N; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Ong KK; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; MRC Unit for Lifelong Health &Ageing at UCL, London WC1B 5JU, UK.; Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK., Oostra BA; Department of Epidemiology, Genetic Epidemiology Unit, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands., Osmond C; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK., Palotie A; Institute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland.; Massachusetts General Hospital, Center for Human Genetic Research, Psychiatric and Neurodevelopmental Genetics Unit, Boston, Massachusetts 02114, USA., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455-0381, USA., Paternoster L; MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS8 1TH, UK., Penninx BW; Department of Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, AJ Ernstraat 1887, 1081 HL Amsterdam, The Netherlands., Pichler I; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy.; Affiliated Institute of the University of Lübeck, 23562 Lübeck, Germany., Pilia MG; Istituto di Ricerca Genetica e Biomedica, CNR, 9042 Monserrato, Italy., Polašek O; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, EH8 9AG Teviot Place, Edinburgh, Scotland.; Department of Public Health, Faculty of Medicine, University of Split, 21000 Split, Croatia., Pramstaller PP; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy.; Affiliated Institute of the University of Lübeck, 23562 Lübeck, Germany.; Department of Neurology, University of Lübeck, 23562 Lübeck, Germany.; Department of Neurology, General Central Hospital, 39100 Bolzano, Italy., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FI-20520 Turku, Finland., Rankinen T; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA., Rao DC; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA., Rayner NW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.; Wellcome Trust Sanger Institute, Human Genetics, Hinxton CB10 1HH, UK., Ribel-Madsen R; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark., Rice TK; Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110, USA., Richards M; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford OX3 7LJ, UK.; MRC Unit for Lifelong Health &Ageing at UCL, London WC1B 5JU, UK., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.; Harvard Medical School, Boston, Massachusetts, 02115, USA., Rivadeneira F; Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands., Ryan KA; Division of Endocrinology, Diabetes &Nutrition, Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA., Sanna S; Istituto di Ricerca Genetica e Biomedica, CNR, 9042 Monserrato, Italy., Sarzynski MA; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA., Scholtens S; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands., Scott RA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Sebert S; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London W12 0NN, UK.; Biocenter Oulu, University of Oulu, Oulu FI-90014, Finland.; Center For Life-Course Health Research, University of Oulu, FI-90014 Oulu, Finland., Southam L; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.; Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK., Sparsø TH; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark., Steinthorsdottir V; deCODE Genetics, Amgen inc., 101 Reykjavik, Iceland., Stirrups K; Wellcome Trust Sanger Institute, Human Genetics, Hinxton, Cambridge CB10 1SA, UK.; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK., Stolk RP; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany., Stringham HM; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA., Swertz MA; Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands., Swift AJ; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA., Tönjes A; Department of Medicine, University of Leipzig, 04103 Leipzig, Germany., Tsafantakis E; Anogia Medical Centre, 74051 Anogia, Greece., van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands., Van Vliet-Ostaptchouk JV; Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands., Vandenput L; Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden., Vartiainen E; Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland., Venturini C; Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.; Institute of Ophthalmology, University College London, London EC1V 9EL, UK., Verweij N; Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands., Viikari JS; Department of Medicine, University of Turku, FI-20521 Turku, Finland.; Division of Medicine, Turku University Hospital, Turku, Finland., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU Edinburgh, Scotland., Vohl MC; Institute of Nutrition and Functional Foods, Laval University, Québec, Québec, Canada G1V 0A6.; School of Nutrition, Laval University, Québec, Québec, Canada G1V 0A6., Vonk JM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands., Waeber G; Department of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland., Widén E; Institute for Molecular Medicine Finland, University of Helsinki, FI-00290 Helsinki, Finland., Willemsen G; Department of Biological Psychology, VU University, 1081BT Amsterdam, The Netherlands., Wilsgaard T; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, 9037 Tromsø, Norway., Winkler TW; Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, 93053 Regensburg, Germany., Wright AF; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU Edinburgh, Scotland., Yerges-Armstrong LM; Division of Endocrinology, Diabetes &Nutrition, Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA., Hua Zhao J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Zillikens MC; Department of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands., Boomsma DI; Department of Biological Psychology, VU University, 1081BT Amsterdam, The Netherlands., Bouchard C; Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Imperial College Healthcare NHS Trust, London W12 0HS, UK., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.; Harvard Medical School, Boston, Massachusetts, 02115, USA., Cusi D; Department of Health Sciences, University of Milano at San Paolo Hospital, 20139 Milano, Italy.; Filarete Foundation, Genomic and Bioinformatics Unit, Milano 20139, Italy., Gansevoort RT; Department of Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, Netherlands., Gieger C; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, 85764 Neuherberg, Germany., Hansen T; Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, 2100 Copenhagen, Denmark.; Faculty of Health Sciences, University of Southern Denmark, 5000 Odense, Denmark., Hicks AA; Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), 39100 Bolzano, Italy.; Affiliated Institute of the University of Lübeck, 23562 Lübeck, Germany., Hu F; Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA., Hveem K; Department of Public Health and General Practice, Norwegian University of Science and Technology, 7489 Trondheim, Norway., Jarvelin MR; Biocenter Oulu, University of Oulu, Oulu FI-90014, Finland.; Unit of Primary Care, Oulu University Hospital, 90029 OYS Oulu, Finland.; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment &Health, School of Public Health, Imperial College London W12 0NN, UK.; Faculty of Medicine, Center for Life Course Epidemiology, University of Oulu, P.O.Box 5000, FI-90014 Oulu, Finland., Kajantie E; Department of Health, National Institute for Health and Welfare (THL), FI-00271 Helsinki, Finland.; Department of Chronic Disease Prevention, National Institute for Health and Welfare, FI-00271 Helsinki, Finland.; Children's Hospital, Helsinki University Hospital and University of Helsinki, FI-00029 Helsinki, Finland.; Department of Obstetrics and Gynecology, MRC Oulu, Oulu University Hospital and University of Oulu, FI-90029 Oulu, Finland., Kooner JS; Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.; Imperial College Healthcare NHS Trust, London W12 0HS, UK.; National Heart and Lung Institute, Imperial College London, London W12 0NN, UK., Kuh D; 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Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands., Uusitupa M; Department of Public Health and Clinical Nutrition, University of Eastern Finland, 70211 Kuopio, Finland.; Research Unit, Kuopio University Hospital, 70029 Kuopio, Finland., Völker U; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, 17475 Greifswald, Germany., Vollenweider P; Department of Internal Medicine, University Hospital Lausanne (CHUV) and University of Lausanne, 1011 Lausanne, Switzerland., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK., Watkins H; 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William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.; Wellcome Trust Sanger Institute, Human Genetics, Hinxton CB10 1HH, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 21589, Saudi Arabia., van Duijn CM; Department of Epidemiology, Genetic Epidemiology Unit, Erasmus University Medical Center, 3015GE Rotterdam, The Netherlands.; Center for Medical Systems Biology, 2300 Leiden, The Netherlands., Fox C; National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.; Harvard Medical School, Boston, Massachusetts, 02115, USA., Groop LC; Lund University Diabetes Centre and Department of Clinical Science, Diabetes &Endocrinology Unit, Lund University, 221 00 Malmö, Sweden.; Finnish Institute for Molecular Medicine (FIMM), Helsinki University, 00014 Helsinki, Finland., Heid IM; 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Publikováno v: Nature communications [Nat Commun] 2016 Nov 23; Vol. 7, pp. 13357. Date of Electronic Publication: 2016 Nov 23.