Zobrazeno 1 - 10
of 736
pro vyhledávání: '"WILLIAM E. EVANS"'
Autor:
Kashi Raj Bhattarai, Robert J. Mobley, Kelly R. Barnett, Daniel C. Ferguson, Baranda S. Hansen, Jonathan D. Diedrich, Brennan P. Bergeron, Satoshi Yoshimura, Wenjian Yang, Kristine R. Crews, Christopher S. Manring, Elias Jabbour, Elisabeth Paietta, Mark R. Litzow, Steven M. Kornblau, Wendy Stock, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Cheng Cheng, Shondra M. Pruett-Miller, Mary V. Relling, Jun J. Yang, William E. Evans, Daniel Savic
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Defining genetic factors impacting chemotherapy failure can help to better predict response and identify drug resistance mechanisms. However, there is limited understanding of the contribution of inherited noncoding genetic variation on inte
Externí odkaz:
https://doaj.org/article/50de02b6348449e7a1264f8dc70d8016
Autor:
Yanling Liu, Jonathon Klein, Richa Bajpai, Li Dong, Quang Tran, Pandurang Kolekar, Jenny L. Smith, Rhonda E. Ries, Benjamin J. Huang, Yi-Cheng Wang, Todd A. Alonzo, Liqing Tian, Heather L. Mulder, Timothy I. Shaw, Jing Ma, Michael P. Walsh, Guangchun Song, Tamara Westover, Robert J. Autry, Alexander M. Gout, David A. Wheeler, Shibiao Wan, Gang Wu, Jun J. Yang, William E. Evans, Mignon Loh, John Easton, Jinghui Zhang, Jeffery M. Klco, Soheil Meshinchi, Patrick A. Brown, Shondra M. Pruett-Miller, Xiaotu Ma
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Oncogenic gene fusions are frequent in childhood cancers but remain poorly understood and untargeted. Here, the authors identify 272 oncogenic fusions in transcriptomics data from 5190 childhood cancer patients, revealing their possible etiologies, t
Externí odkaz:
https://doaj.org/article/4295bf024052418d8f3bd3d5099ce979
Autor:
Yang Li, Thomas Drabison, Mahesh Nepal, Richard H. Ho, Alix F. Leblanc, Alice A. Gibson, Yan Jin, Wenjian Yang, Kevin M. Huang, Muhammad Erfan Uddin, Mingqing Chen, Duncan F. DiGiacomo, Xihui Chen, Sobia Razzaq, Jeffrey R. Tonniges, Dana M. McTigue, Alice S. Mims, Maryam B. Lustberg, Yijia Wang, Amanda B. Hummon, William E. Evans, Sharyn D. Baker, Guido Cavaletti, Alex Sparreboom, Shuiying Hu
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Vincristine is a widely used chemotherapeutic drug for the treatment of multiple malignant diseases that causes a dose-limiting peripheral neurotoxicity. There is no clinically effective preventative treatment for vincristine-induced sensory peripher
Externí odkaz:
https://doaj.org/article/ce9d6058dddc4a1f9ae29073d522d78d
Autor:
Barthelemy Diouf, Claudia Wing, John C. Panetta, Donnie Eddins, Wenwei Lin, Wenjian Yang, Yiping Fan, Deqing Pei, Cheng Cheng, Shannon M. Delaney, Wei Zhang, Erik J. Bonten, Kristine R. Crews, Steven W. Paugh, Lie Li, Burgess B. Freeman 3rd, Robert J. Autry, Jordan A. Beard, Daniel C. Ferguson, Laura J. Janke, Kirsten K. Ness, Taosheng Chen, Stanislav S. Zakharenko, Sima Jeha, Ching‐Hon Pui, Mary V. Relling, M. Eileen Dolan, William E. Evans
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 4, Pp 1490-1504 (2021)
Abstract Vincristine (VCR) is one of the most widely prescribed medications for treating solid tumors and acute lymphoblastic leukemia (ALL) in children and adults. However, its major dose‐limiting toxicity is peripheral neuropathy that can disrupt
Externí odkaz:
https://doaj.org/article/e3e40089bb0343279b5f3003e28e87aa
Autor:
Seth E. Karol, Yilun Sun, Li Tang, Ching‐Hon Pui, Jose Ferrolino, Kim J. Allison, Shane J. Cross, William E. Evans, Kristine R. Crews, Sima Jeha, Joshua Wolf
Publikováno v:
Cancer Medicine, Vol 9, Iss 18, Pp 6550-6555 (2020)
Abstract Background Fluoroquinolone antibiotics are frequently utilized in pediatric oncology patients as prophylaxis or step‐down therapy following broad spectrum beta‐lactam therapy for febrile neutropenia. Concerns regarding neurotoxicity limi
Externí odkaz:
https://doaj.org/article/30ab802283d544e0bc7e7ddcd3164607
Autor:
Jayaram Vijayakrishnan, Maoxiang Qian, James B. Studd, Wenjian Yang, Ben Kinnersley, Philip J. Law, Peter Broderick, Elizabeth A. Raetz, James Allan, Ching-Hon Pui, Ajay Vora, William E. Evans, Anthony Moorman, Allen Yeoh, Wentao Yang, Chunliang Li, Claus R. Bartram, Charles G. Mullighan, Martin Zimmerman, Stephen P. Hunger, Martin Schrappe, Mary V. Relling, Martin Stanulla, Mignon L. Loh, Richard S. Houlston, Jun J. Yang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
B-cell acute lymphoblastic leukaemia (B-ALL) is a common childhood cancer. Here, the authors conducted a meta-analysis with four genome-wide association studies, totalling 5,321 cases and 16,666 controls of European descent, identifying B-ALL risk lo
Externí odkaz:
https://doaj.org/article/fe499f58e3cb45709aa02c81074cf619
Autor:
Jesse Bakke, William C. Wright, Anthony E. Zamora, Peter Oladimeji, Jeremy Chase Crawford, Christopher T. Brewer, Robert J. Autry, William E. Evans, Paul G. Thomas, Taosheng Chen
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)
Abstract Background Despite its relatively low incidence, pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths because of the aggressive growth/metastasis of the tumor, the lack of early symptoms, and the poor treatment options
Externí odkaz:
https://doaj.org/article/6c1f1fe0340d487ab16e02706b6671bb
Autor:
Seth E. Karol, Deqing Pei, Colton A. Smith, Yiwei Liu, Wenjian Yang, Nancy M. Kornegay, John C. Panetta, Kristine R. Crews, Cheng Cheng, Emily R. Finch, Hiroto Inaba, Monika L. Metzger, Jeffrey E. Rubnitz, Raul C. Ribeiro, Tanja A. Gruber, Jun J. Yang, William E. Evans, Sima Jeha, Ching-Hon Pui, Mary V. Relling
Publikováno v:
Haematologica, Vol 107, Iss 2 (2021)
Chemotherapy dosages are often compromised, but most reports lack data on dosages that are actually delivered. In two consecutive acute lymphoblastic leukemia trials that differed in their asparaginase formulation, native E. coli L-asparaginase in St
Externí odkaz:
https://doaj.org/article/f2f424e701944bfb90237067ca32533f
Autor:
William E. Evans
Publikováno v:
Haematologica, Vol 106, Iss 11 (2021)
Externí odkaz:
https://doaj.org/article/45c757063ee54232b5ad6eaef949eea5
Autor:
Elixabet Lopez-Lopez, William E. Evans
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 1 (2021)
Measuring the amount of methotrexate polyglutamates (MTXPG) in leukemia cells after high-dose methotrexate (HDMTX) revealed that molecular subtype and lineage of acute lymphoblastic leukemia (ALL), the ratio of expression of folate influx and efflux
Externí odkaz:
https://doaj.org/article/0545816fc3e040f18e9790eb5acc3740