Zobrazeno 1 - 10
of 253
pro vyhledávání: '"WILLIAM A. CANNON"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract High performance computing has a great potential to provide a range of significant benefits for investigating biological systems. These systems often present large modelling problems with many coupled subsystems, such as when studying coloni
Externí odkaz:
https://doaj.org/article/a59004e3ece349299bc016c6c012678d
Publikováno v:
Frontiers in Systems Biology, Vol 3 (2023)
Elucidating cell regulation remains a challenging task due to the complexity of metabolism and the difficulty of experimental measurements. Here we present a method for prediction of cell regulation to maximize cell growth rate while maintaining the
Externí odkaz:
https://doaj.org/article/4cd7064f4bd74b86b26a51252d1be63d
Autor:
Carlin J. Green, Julia Nord, Robert R. Seal, Nadine M. Piatak, Ryan J. McAleer, William F. Cannon
Publikováno v:
American Mineralogist. 105:1259-1269
The Paleoproterozoic Ironwood Iron-Formation, a Superior-type banded iron formation located in the western Gogebic Iron Range in Wisconsin, is one of the largest undeveloped iron ore resources in the United States. Interest in the development of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b75c77a6594199ca0d608a48321668d5
https://doi.org/10.2138/am-2020-7211
https://doi.org/10.2138/am-2020-7211
Autor:
Lionel M. Raff, William R. Cannon
Publikováno v:
Physical chemistry chemical physics : PCCP. 23(27)
In 1994, an IUBMB–IUPAC joint committee recommended a revised formulation for standard chemical potentials and reaction free energies motivated by the fact that, in biochemistry, the reactants and products often exist in multiple charge states depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493bc60f3e2c33a5de3260a77a2b08fe
https://pubmed.ncbi.nlm.nih.gov/34196644
https://pubmed.ncbi.nlm.nih.gov/34196644
Autor:
Adrian Buganza Tepole, William W. Lytton, Linda R. Petzold, William R. Cannon, Salvador Dura-Bernal, Ellen Kuhl, Mark Alber, George Em Karniadakis, Krishna Garikipati, Suvranu De, Paris Perdikaris
Publikováno v:
npj Digital Medicine, Vol 2, Iss 1, Pp 1-11 (2019)
NPJ digital medicine, vol 2, iss 1
NPJ Digital Medicine
NPJ digital medicine, vol 2, iss 1
NPJ Digital Medicine
Fueled by breakthrough technology developments, the biological, biomedical, and behavioral sciences are now collecting more data than ever before. There is a critical need for time- and cost-efficient strategies to analyze and interpret these data to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85abd7dba255e2137deb9e02c4b552c9
http://link.springer.com/article/10.1038/s41746-019-0193-y
http://link.springer.com/article/10.1038/s41746-019-0193-y
Autor:
Lionel M. Raff, William R. Cannon
Publikováno v:
Journal of Chemical Education. 96:274-284
For 26 years, it has been assumed by some that the thermodynamics of open-system biochemical reactions must be executed by performing Legendre transformations on the terms involving the species whose concentrations are being held fixed. In contrast,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f26a5202bf976fee2d5f8599dddf82af
https://doi.org/10.1021/acs.jchemed.8b00795
https://doi.org/10.1021/acs.jchemed.8b00795
Autor:
William R. Cannon
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 2 (2014)
The modeling of the chemical reactions involved in metabolism is a daunting task. Ideally, the modeling of metabolism would use kinetic simulations, but these simulations require knowledge of the thousands of rate constants involved in the reactions.
Externí odkaz:
https://doaj.org/article/592277483e204d8bbedf161a48a3b355
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e86855 (2014)
Soil represents the largest store of mercury (Hg) in terrestrial ecosystems, and further study of the factors associated with soil Hg storage is needed to address concerns about the magnitude and persistence of global environmental Hg bioaccumulation
Externí odkaz:
https://doaj.org/article/622f215da5254be695dded38cc0b2984
Autor:
William R Cannon
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103582 (2014)
New methods are needed for large scale modeling of metabolism that predict metabolite levels and characterize the thermodynamics of individual reactions and pathways. Current approaches use either kinetic simulations, which are difficult to extend to
Externí odkaz:
https://doaj.org/article/b4d724c584c84659bf6e80becccb3d30
Publikováno v:
Proceedings of Entropy 2021: The Scientific Tool of the 21st Century.
Experimental measurement or computational inference/prediction of the enzyme regulation needed in a metabolic pathway is hard problem. Consequently, regulation is known only for well-studied reactions of central metabolism in a few organisms. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63b6e042811c9b94dd0e97400f049ec1
https://doi.org/10.3390/entropy2021-09867
https://doi.org/10.3390/entropy2021-09867