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Introduction Combined thermal and fluid modeling is useful for design and optimization of cyclotron water targets. Previous heat transfer models assumed either a distribution of void under saturation conditions [1] or a static volumetric heat distrib
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Introduction Batch-style water targets used for F-18 production are known to operate under boiling conditions in the target irradiation chamber, but the distribution of vapor under steady-state conditions was previously unknown. Thermal performance o
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Role of cell metabolism in the pathophysiology of brain size-associated neurodevelopmental disorders
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106607- (2024)
Cell metabolism is a key regulator of human neocortex development and evolution. Several lines of evidence indicate that alterations in neural stem/progenitor cell (NPC) metabolism lead to abnormal brain development, particularly brain size-associate
Externí odkaz:
https://doaj.org/article/8be3c9af9d154509b399288606189a6a
Autor:
Lei Xing, Vasiliki Gkini, Anni I. Nieminen, Hui-Chao Zhou, Matilde Aquilino, Ronald Naumann, Katrin Reppe, Kohichi Tanaka, Peter Carmeliet, Oskari Heikinheimo, Svante Pääbo, Wieland B. Huttner, Takashi Namba
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Metabolism has recently emerged as a major target of genes implicated in the evolutionary expansion of human neocortex. One such gene is the human-specific gene ARHGAP11B. During human neocortex development, ARHGAP11B increases the abundance
Externí odkaz:
https://doaj.org/article/7f5a9fcd3d7146608de6b3e645883f2f
Role of cell metabolism in the pathophysiology of brain size-associated neurodevelopmental disorders
Publikováno v:
In Neurobiology of Disease September 2024 199
Autor:
Aboah, J., Campbell, Z.A., Dione, M., Kotchofa, P., Guy, I., Wieland, B., Lo, M.M., Rich, K.M.
Publikováno v:
In Agricultural Systems May 2024 217
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The development of the neocortex involves an interplay between neural cells and the vasculature. However, little is known about this interplay at the ultrastructural level. To gain a 3D insight into the ultrastructure of the developing neocortex, we
Externí odkaz:
https://doaj.org/article/92e2aa255f2c4d67b0c867f7789a9daa
Autor:
Michael Heide, Wieland B. Huttner
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
As is evident from the theme of the Research Topic “Small Size, Big Problem: Understanding the Molecular Orchestra of Brain Development from Microcephaly,” the pathomechanisms leading to mirocephaly in human are at best partially understood. As m
Externí odkaz:
https://doaj.org/article/a4cf26ef57b5413a98dfc44f1df59344
Autor:
Namba, Takashi, Huttner, Wieland B.
Publikováno v:
Annual Review of Cell & Developmental Biology; Oct2024, Vol. 40 Issue 1, p427-452, 21p