Zobrazeno 1 - 10
of 63
pro vyhledávání: '"WGA, wheat germ agglutinin"'
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2416-2448 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2416-2448 (2021)
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules than small molecular drugs due to their high selectivity and efficacy, but fewer side effects. Owing to the poor stability and limited permeability through gastro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6732d4326595a5ad29955ebaff92173
https://doi.org/10.1016/j.apsb.2021.04.001
https://doi.org/10.1016/j.apsb.2021.04.001
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1517-1529 (2021)
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 5, Pp 1517-1529 (2021)
Background & Aims Autosomal recessive polycystic kidney disease (ARPKD) is caused by mutations in PKHD1, encoding fibrocystin/polyductin (FPC). Severe disease occurs in perinates. Those who survive the neonatal period face a myriad of comorbidities,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eaad8f75a984645da5b03d61f582973
http://europepmc.org/articles/PMC8529398
http://europepmc.org/articles/PMC8529398
Autor:
Peiqing Liu, Zhuoming Li, Junjian Wang, Sidong Cai, Rui Lan, Zhirong Lin, Zhen Guo, Jingyan Li, Zhenzhen Li
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1286-1299 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
The bromodomain and extraterminal (BET) family member BRD4 is pivotal in the pathogenesis of cardiac hypertrophy. BRD4 induces hypertrophic gene expression by binding to the acetylated chromatin, facilitating the phosphorylation of RNA polymerases II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fde96e7c9d22c0d4144a0bf59c2cb8
http://www.sciencedirect.com/science/article/pii/S2211383520308455
http://www.sciencedirect.com/science/article/pii/S2211383520308455
Autor:
Stacy A. Malaker, Samuel A. Myers, Xiang Li, Anjana Rao, Steven A. Carr, Johain R. Ounadjela, Borislav Dejanovic, Rajan A. Burt, Hayley J. Peckham, Kimberly Lee
Publikováno v:
Molecular & Cellular Proteomics : MCP
Antibodies against posttranslational modifications (PTMs) such as lysine acetylation, ubiquitin remnants, or phosphotyrosine have resulted in significant advances in our understanding of the fundamental roles of these PTMs in biology. However, the ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda670d6710bf78ea26f49e8a7bf388b
http://europepmc.org/articles/PMC8605273
http://europepmc.org/articles/PMC8605273
Autor:
Yukako Domoto, Yumiko Hosoya, Masamichi Ito, Toshiyuki Ko, Hiroyuki Morita, Yukari Uemura, Takashige Tobita, Shintaro Yamada, Masaru Hatano, Kanna Fujita, Issei Komuro, Seitaro Nomura, Eisuke Amiya, Masashi Fukayama, Manami Katoh, Masahiro Satoh, Hiroyuki Aburatani
Publikováno v:
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 4, Iss 6, Pp 670-680 (2019)
JACC: Basic to Translational Science, Vol 4, Iss 6, Pp 670-680 (2019)
Visual Abstract
Highlights • Patients with dilated cardiomyopathy who achieved LVRR have a favorable prognosis, but it is still difficult to precisely predict LVRR in the clinical setting. • Immunostaining of DNA damage markers such as PAR i
Highlights • Patients with dilated cardiomyopathy who achieved LVRR have a favorable prognosis, but it is still difficult to precisely predict LVRR in the clinical setting. • Immunostaining of DNA damage markers such as PAR i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174547be6b56c9c36389f195a29ed5b0
http://europepmc.org/articles/PMC6834953
http://europepmc.org/articles/PMC6834953
Publikováno v:
Toxicology Reports, Vol 6, Iss, Pp 358-368 (2019)
Toxicology Reports
Toxicology Reports
Highlights • Nanotechnology facilitates oral administration of drugs. • Various nanostructures have been designed for this purpose. • These nanoformulations are useful for many diseases.
The most preferable mode of drugs administration is
The most preferable mode of drugs administration is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc1333c014619f53502c3e9e3722368
https://doi.org/10.1016/j.toxrep.2019.04.004
https://doi.org/10.1016/j.toxrep.2019.04.004
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 1, Pp 36-48 (2019)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility and safety. Despite the success of parenteral liposomes, oral delivery of liposomes is impeded by various b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885b6fe25347501148a570cf5137d649
https://doi.org/10.1016/j.apsb.2018.06.005
https://doi.org/10.1016/j.apsb.2018.06.005
Autor:
Monica L. Husby, Kaveesha J. Wijesinghe, Robert V. Stahelin, Stephanie Angel, Souad Amiar, Nisha Bhattarai, Sheng Li, Prem P. Chapagain, Bernard S. Gerstman
Publikováno v:
The Journal of Biological Chemistry
Marburg virus (MARV) is a lipid-enveloped virus harboring a negative-sense RNA genome, which has caused sporadic outbreaks of viral hemorrhagic fever in sub-Saharan Africa. MARV assembles and buds from the host cell plasma membrane where MARV matrix
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c596ddf7083efd6e77a8422284dff29e
http://europepmc.org/articles/PMC8191294
http://europepmc.org/articles/PMC8191294
Publikováno v:
The Journal of Biological Chemistry
The extracellular matrix (ECM) plays an important role in maintaining tissue homeostasis and poses a significant physical barrier to in vivo cell migration. Accordingly, as a means of enhancing tissue invasion, tumor cells use matrix metalloproteinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6093ca0e137f8e3d73b1f7f4cbf3f7
http://europepmc.org/articles/PMC8042168
http://europepmc.org/articles/PMC8042168
Autor:
Robert J. Chalkley, Jason C. Maynard
Publikováno v:
Molecular & Cellular Proteomics : MCP
O-GlcNAcylation, the addition of a single N-acetylglucosamine residue to serine and threonine residues of cytoplasmic, nuclear, or mitochondrial proteins, is a widespread regulatory posttranslational modification. It is involved in the response to nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab46d9819ff8a3762c365a1ea27d84de
http://europepmc.org/articles/PMC8724609
http://europepmc.org/articles/PMC8724609