Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19.

Autor: Aznaourova M; Institute for Lung Research, Philipps University Marburg, 35043 Marburg, Germany., Schmerer N; Institute for Lung Research, Philipps University Marburg, 35043 Marburg, Germany., Janga H; Institute for Lung Research, Philipps University Marburg, 35043 Marburg, Germany., Zhang Z; Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine & TWINCORE, joint ventures between the Helmholtz-Centre for Infection Research and the Hannover Medical School, 30625 Hannover, Germany.; Department of Genetics, University of Groningen and University Medical Center Groningen, 9713 AV, Groningen, The Netherlands., Pauck K; Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, Philipps University Marburg, 35043 Marburg, Germany., Bushe J; Institute of Veterinary Pathology, Freie Universitaet Berlin, 14195 Berlin, Germany., Volkers SM; Department of Infectious Diseases and Respiratory Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Wendisch D; Department of Infectious Diseases and Respiratory Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Georg P; Department of Infectious Diseases and Respiratory Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany., Ntini E; Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.; Institute of Molecular Biology and Biotechnology, FORTH, Heraklion, GR-70013, Greece., Aillaud M; Institute for Lung Research, Philipps University Marburg, 35043 Marburg, Germany., Gündisch M; Institute of Laboratory Medicine, Philipps University Marburg, 35043 Marburg, Germany., Mack E; Department of Hematology, Oncology and Immunology, Philipps University Marburg, University Hospital Giessen and Marburg, 35043 Marburg, Germany., Skevaki C; Institute of Laboratory Medicine, Philipps University Marburg, 35043 Marburg, Germany.; Universities of Giessen and Marburg Lung Center (UGMLC), Giessen, 35392 Germany.; German Center for Lung Research (DZL), Giessen, 35392 Germany., Keller C; Institute of Virology, University Hospital Giessen and Marburg, 35043 Marburg, Germany., Bauer C; Department of Gastroenterology, Endocrinology, Metabolism and Infectiology, University Hospital of Giessen and Marburg, Philipps University Marburg, 35043 Marburg, Germany., Bertrams W; Institute for Lung Research, Philipps University Marburg, 35043 Marburg, Germany., Marsico A; Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.; Institute for Computational Biology, Helmholtz Centre, 85764 Munich, Germany., Nist A; Genomics Core Facility, Philipps University Marburg, 35043 Marburg, Germany., Stiewe T; German Center for Lung Research (DZL), Giessen, 35392 Germany.; Genomics Core Facility, Philipps University Marburg, 35043 Marburg, Germany.; Institute of Molecular Oncology, Philipps University Marburg, 35043 Marburg, Germany., Gruber AD; Institute of Veterinary Pathology, Freie Universitaet Berlin, 14195 Berlin, Germany., Ruppert C; Universities of Giessen and Marburg Lung Center (UGMLC), Giessen, 35392 Germany.; German Center for Lung Research (DZL), Giessen, 35392 Germany.; UGMLC Giessen Biobank and european IPF registry (eurIPFreg), Giessen, 35392 Germany., Li Y; Department of Computational Biology for Individualised Medicine, Centre for Individualised Infection Medicine & TWINCORE, joint ventures between the Helmholtz-Centre for Infection Research and the Hannover Medical School, 30625 Hannover, Germany.; Department of Internal Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands., Garn H; Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, Philipps University Marburg, 35043 Marburg, Germany.; German Center for Lung Research (DZL), Giessen, 35392 Germany., Sander LE; Department of Infectious Diseases and Respiratory Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 10117 Berlin, Germany.; German Center for Lung Research (DZL), Giessen, 35392 Germany., Schmeck B; Institute for Lung Research, Philipps University Marburg, 35043 Marburg, Germany.; German Center for Lung Research (DZL), Giessen, 35392 Germany.; Department of Respiratory and Critical Care Medicine, University Medical Center Marburg, 35043 Marburg, Germany.; Center for Synthetic Microbiology, Philipps University Marburg, 35043 Marburg, Germany.; German Center of Infection Research, 35043 Marburg, Germany., Schulte LN; Institute for Lung Research, Philipps University Marburg, 35043 Marburg, Germany.; German Center for Lung Research (DZL), Giessen, 35392 Germany.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Sep 06; Vol. 119 (36), pp. e2120680119. Date of Electronic Publication: 2022 Aug 23.

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.

Autor: Wendisch D; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany., Dietrich O; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI), Würzburg, Germany., Mari T; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Proteome Dynamics, Berlin, Germany., von Stillfried S; Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany., Ibarra IL; Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Mittermaier M; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany; Berlin Institute of Health (BIH), Berlin, Germany., Mache C; Unit 17 Influenza and other Respiratory Viruses, Robert Koch Institute, Berlin, Germany., Chua RL; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Knoll R; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Germany., Timm S; Core Facility Electron Microscopy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Brumhard S; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany., Krammer T; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI), Würzburg, Germany., Zauber H; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Proteome Dynamics, Berlin, Germany., Hiller AL; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany., Pascual-Reguant A; Charité - Universitätsmedizin Berlin, Department of Rheumatology and Clinical Immunology, Charité; Deutsches Rheumaforschungszentrum, Immunodynamics, a Leibniz Institute, Berlin, Germany., Mothes R; Deutsches Rheumaforschungszentrum, Immunodynamics, a Leibniz Institute, Berlin, Germany; Charité - Universitätsmedizin Berlin, Department of Neuropathology, Berlin, Germany., Bülow RD; Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany., Schulze J; Unit 17 Influenza and other Respiratory Viruses, Robert Koch Institute, Berlin, Germany., Leipold AM; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI), Würzburg, Germany., Djudjaj S; Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany., Erhard F; Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg, Würzburg, Germany., Geffers R; Genome Analytics, Helmholtz-Center for Infection Research (HZI), Braunschweig, Germany., Pott F; Berlin Institute of Health (BIH), Berlin, Germany; Charité - Universitätsmedizin Berlin, Institute of Virology, Charité Universitätsmedizin Berlin, Berlin, Germany., Kazmierski J; Berlin Institute of Health (BIH), Berlin, Germany; Charité - Universitätsmedizin Berlin, Institute of Virology, Charité Universitätsmedizin Berlin, Berlin, Germany., Radke J; Berlin Institute of Health (BIH), Berlin, Germany; Charité - Universitätsmedizin Berlin, Department of Neuropathology, Berlin, Germany., Pergantis P; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany., Baßler K; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Germany., Conrad C; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany., Aschenbrenner AC; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Germany; PRECISE Platform for Genomics and Epigenomics at Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), and University of Bonn, Bonn, Germany; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands., Sawitzki B; Charité, Universitätsmedizin Berlin, Institute of Medical Immunology, Charité, Universitätsmedizin Berlin, Berlin, Germany., Landthaler M; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Wyler E; Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany., Horst D; Charité - Universitätsmedizin Berlin, Institute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Hippenstiel S; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL), Germany., Hocke A; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL), Germany., Heppner FL; Charité - Universitätsmedizin Berlin, Department of Neuropathology, Berlin, Germany; Cluster of Excellence, NeuroCure, Berlin, Germany; German Center for Neurodegenerative Diseases (DZNE) Berlin, Berlin, Germany., Uhrig A; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany., Garcia C; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany., Machleidt F; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany., Herold S; German Center for Lung Research (DZL), Germany; Division of Infectious Diseases, Pulmonary and Critical Care Medicine, Department of Internal Medicine II, Universities of Giessen and Marburg Lung Center, Giessen, Germany; Institute of Lung Health (ILH), Giessen, Germany., Elezkurtaj S; Charité - Universitätsmedizin Berlin, Institute of Pathology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Thibeault C; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany., Witzenrath M; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL), Germany., Cochain C; Comprehensive Heart Failure Center Wuerzburg, University Hospital Würzburg, Germany; Institute of Experimental Biomedicine, University Hospital Würzburg, Würzburg, Germany., Suttorp N; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL), Germany., Drosten C; Charité - Universitätsmedizin Berlin, Institute of Virology, Charité Universitätsmedizin Berlin, Berlin, Germany; German Center for Infection Research (DZIF), Braunschweig, Germany., Goffinet C; Berlin Institute of Health (BIH), Berlin, Germany; Charité - Universitätsmedizin Berlin, Institute of Virology, Charité Universitätsmedizin Berlin, Berlin, Germany., Kurth F; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany; I. Department of Medicine, University Medical Center, Hamburg-Eppendorf, Hamburg, Germany., Schultze JL; Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Germany; PRECISE Platform for Genomics and Epigenomics at Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), and University of Bonn, Bonn, Germany., Radbruch H; Charité - Universitätsmedizin Berlin, Department of Neuropathology, Berlin, Germany., Ochs M; Core Facility Electron Microscopy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Center for Lung Research (DZL), Germany; Institute of Functional Anatomy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Eils R; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Müller-Redetzky H; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany., Hauser AE; Charité - Universitätsmedizin Berlin, Department of Rheumatology and Clinical Immunology, Charité; Deutsches Rheumaforschungszentrum, Immunodynamics, a Leibniz Institute, Berlin, Germany., Luecken MD; Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Theis FJ; Institute of Computational Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Department of Mathematics, Technische Universität München, Garching bei München, Germany., Conrad C; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Wolff T; Unit 17 Influenza and other Respiratory Viruses, Robert Koch Institute, Berlin, Germany., Boor P; Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany., Selbach M; Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Proteome Dynamics, Berlin, Germany; Charité-Universitätsmedizin Berlin, Berlin, Germany., Saliba AE; Helmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz-Center for Infection Research (HZI), Würzburg, Germany. Electronic address: emmanuel.saliba@helmholtz-hiri.de., Sander LE; Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL), Germany. Electronic address: leif-erik.sander@charite.de.

Publikováno v: Cell [Cell] 2021 Dec 22; Vol. 184 (26), pp. 6243-6261.e27. Date of Electronic Publication: 2021 Nov 27.

Proteomic Profiling of COVID-19 Patients Sera: Differential Expression with Varying Disease Stage and Potential Biomarkers.

Autor: Dandachi, Iman¹ (AUTHOR) iman.j.d@hotmail.com, Alaiya, Ayodele² (AUTHOR) aalaiya@kfshrc.edu.sa, Shinwari, Zakia² (AUTHOR) szakia@kfshrc.edu.sa, Abbas, Basma³ (AUTHOR) bma_1403@hotmail.com, Karkashan, Alaa³ (AUTHOR) askarkashan@uj.edu.sa, Al-Amari, Ahod⁴ (AUTHOR) ahod.k.a@gmail.com, Aljabr, Waleed^1,5,6 (AUTHOR) wajabr@pha.gov.sa

Publikováno v: Diagnostics (2075-4418). Nov2024, Vol. 14 Issue 22, p2533. 19p.

Dynamic Changes in Lymphocyte Populations and Their Relationship with Disease Severity and Outcome in COVID-19.

Autor: Andrejkovits, Ákos Vince^1,2 (AUTHOR) akos.andrejkovits@umfst.ro, Huțanu, Adina^3,4 (AUTHOR) doina.manu@umfst.ro, Manu, Doina Ramona⁴ (AUTHOR), Dobreanu, Minodora^3,4 (AUTHOR), Văsieșiu, Anca Meda^1,5 (AUTHOR) anca.vasiesiu@gmail.com

Publikováno v: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 22, p11921. 18p.

Cross-Reactive Immune Response of Bovine Coronavirus Spike Glycoprotein to SARS-CoV-2 Variants of Concern.

Autor: Cossu, Chiara¹ (AUTHOR) chiara.cossu@unito.it, Franceschi, Valentina² (AUTHOR) valentina.franceschi@unipr.it, Di Lorenzo, Antonino¹ (AUTHOR) antonino.dilorenzo@unito.it, Bolli, Elisabetta¹ (AUTHOR) elisabetta.bolli@unito.it, Minesso, Sergio² (AUTHOR) sergio.minesso@unipr.it, Cotti, Camilla² (AUTHOR) camilla.cotti@studenti.unipr.it, Conti, Laura¹ (AUTHOR) laura.conti@unito.it, Donofrio, Gaetano² (AUTHOR) laura.conti@unito.it

Publikováno v: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 21, p11509. 14p.