Zobrazeno 1 - 10
of 717
pro vyhledávání: '"WEIDONG XIAO"'
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Breast cancer is one of the most threatening women health diseases worldwide and its molecular heterogeneity offers a range of response to therapy. The role of polyamine metabolism is receiving increasing attention. Polyamine metabolism not
Externí odkaz:
https://doaj.org/article/c1d9e3dffc4f4125b84e6667c8f29f0d
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Current gene therapy for Duchenne muscular dystrophy (DMD) utilizes adeno-associated virus (AAV) to deliver micro-dystrophin (µDys), which does not provide full protection for striated muscles as it lacks many important functional domains o
Externí odkaz:
https://doaj.org/article/99a49e53f4014a01a4aca707caf156f6
Autor:
Yihui Chen, Ben Han, Xu Guan, Guangsheng Du, Baifa Sheng, Xiaoqi Tang, Quanchao Zhang, Huichao Xie, Xianhong Jiang, Qianshan Tan, Shuaishuai Chen, Jian Wang, Wei Chen, Weidong Xiao
Publikováno v:
Journal of Advanced Research, Vol 61, Iss , Pp 223-237 (2024)
Introduction: Prophylactic antifungal therapy has been widely used for critical patients, but it has failed to improve patient prognosis and has become a hot topic. This may be related to disruption of fungal homeostasis, but the mechanism of fungi a
Externí odkaz:
https://doaj.org/article/c8695ffdae9e40019552fcc3bfba9e51
Autor:
Shenhai Gong, Yunong Zeng, Ze Wang, Yanru Li, Rong Wu, Lei Li, Hongbin Hu, Ping Qin, Zhichao Yu, Xintao Huang, Peiheng Guo, Hong Yang, Yi He, Zhibin Zhao, Weidong Xiao, Xiaoshan Zhao, Lei Gao, Shumin Cai, Zhenhua Zeng
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI), with gender-specific differences in susceptibility. However, the mechanism underlying this phenomenon remains unclear. Our study reveals that the gender-specific di
Externí odkaz:
https://doaj.org/article/e1333a7e75224522889e1baa37929b5b
Publikováno v:
European Journal of Medical Research, Vol 29, Iss 1, Pp 1-15 (2024)
Abstract Background Previous studies have found that frailty and sarcopenia are commonly diagnosed in inflammatory bowel disease (IBD) patients, indicating an association between these conditions. Nonetheless, the cause‒effect connection between IB
Externí odkaz:
https://doaj.org/article/e98e0ae8b791452bad5a0e7a4b0a0812
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract Background Inflammatory Bowel Diseases (IBD), an autoimmune disease characterised by abnormal intestinal immunity, are related to vital morbidity around the world. However, therapeutic agents for IBD have not achieved desired benefit. Explor
Externí odkaz:
https://doaj.org/article/01277a728c034bcc967279e59af27d93
Publikováno v:
Mathematics, Vol 12, Iss 22, p 3489 (2024)
The traditional model training approach based on negative sampling randomly samples a portion of negative samples for training, which can easily overlook important negative samples and adversely affect the training of knowledge graph embedding models
Externí odkaz:
https://doaj.org/article/4aa0d641406c477baeacaefb71b8c6a4
Publikováno v:
Mathematics, Vol 12, Iss 20, p 3237 (2024)
Knowledge graph embedding represents entities and relations as low-dimensional continuous vectors. Recently, researchers have attempted to leverage the potential semantic connections between entities with hierarchical relationships in the knowledge g
Externí odkaz:
https://doaj.org/article/3caa28a01de8427fb34ca9b6da215c39
Autor:
Yihui Chen, Xiaoqi Tang, Xiong Zeng, Ben Han, Huichao Xie, Wei Wang, Lihua Sun, Mingdong Hu, Yuqi Gao, Weidong Xiao
Publikováno v:
Travel Medicine and Infectious Disease, Vol 59, Iss , Pp 102718- (2024)
Background: The diagnosis and evaluation of the severity of acute mountain sickness (AMS) continue to be problematic due to a lack of consensus on the inclusion of symptoms in a scoring system. Recent investigations highlight the significance of gast
Externí odkaz:
https://doaj.org/article/4d0b297af0be40c2b3c032031357cfe5
Autor:
Yuan Gao, Kun Zhao, Yulan Huang, Dapeng Zhang, Na Luo, Xiaoqing Peng, Feng Yang, Weidong Xiao, Meng Wang, Rongchen Shi, Hongming Miao
Publikováno v:
MedComm, Vol 5, Iss 4, Pp n/a-n/a (2024)
Abstract Lipid metabolic reprogramming is closely related to tumor progression with the mechanism not fully elucidated. Here, we report the immune‐regulated role of lanosterol synthase (LSS), an essential enzyme in cholesterol synthesis. Database a
Externí odkaz:
https://doaj.org/article/a63f6ed4131f47fd8a842c7a1dd11900