Missing WD40 Repeats in ATG16L1 Delays Canonical Autophagy and Inhibits Noncanonical Autophagy.

Autor: Tang J; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, Guangzhou 510006, China., Fang D; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, Guangzhou 510006, China., Zhong J; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, Guangzhou 510006, China., Li M; State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.; Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, Guangzhou 510006, China.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 19; Vol. 25 (8). Date of Electronic Publication: 2024 Apr 19.

Variants in the WDR44 WD40-repeat domain cause a spectrum of ciliopathy by impairing ciliogenesis initiation.

Autor: Accogli A; Division of Medical Genetics, Department of Specialized Medicine, McGill University Health Centre (MUHC), Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada., Shakya S; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Yang T; Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, 08826, Seoul, Republic of Korea., Insinna C; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Kim SY; Department of Genomic Medicine, Seoul National University Hospital, 03080, Seoul, Republic of Korea., Bell D; Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Butov KR; Department of Immunology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, 117997, Russia.; Department of Molecular Biology and Medical Biotechnology, Pirogov Russian National Research Medical University, Moscow, 117997, Russia., Severino M; Neuroradiology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Niceta M; Molecular Genetics and Functional Genomics, Ospedale Pediatrico Bambino Gesù, IRCCS, 00146, Rome, Italy., Scala M; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Università Degli Studi di Genova, Genoa, Italy.; Pediatric Neurology and Muscular Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Lee HS; School of Biological Sciences, Seoul National University, 08826, Seoul, Republic of Korea., Yoo T; Department of Biomedical Sciences, Seoul National University College of Medicine, 03080, Seoul, Republic of Korea., Stauffer J; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Zhao H; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Fiorillo C; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Università Degli Studi di Genova, Genoa, Italy.; Child Neuropsychiatry, IRCCS Istituto G.Gaslini, DINOGMI University of Genova, Largo Gaslini 5, Genoa, Italy., Pedemonte M; Pediatric Neurology and Muscular Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Diana MC; Pediatric Neurology and Muscular Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy., Baldassari S; Unit of Medical Genetics, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy., Zakharova V; National Medical Research Center for Endocrinology, Clinical data analysis department, Moscow, Russian Federation, Russia., Shcherbina A; Department of Immunology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, 117997, Russia., Rodina Y; Department of Immunology, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, 117997, Russia., Fagerberg C; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Roos LS; Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, København, Denmark., Wierzba J; Department of Pediatrics and Internal Medicine Nursing, Department of Rare Disorders, Medical University of Gdansk, Gdansk, Poland., Dobosz A; Department of Medical Genetics, Faculty of Medicine, Jagiellonian University Medical College, 30-663, Krakow, Poland., Gerard A; Texas Children's Hospital, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Potocki L; Texas Children's Hospital, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Rosenfeld JA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Baylor Genetics Laboratories, Houston, TX, USA., Lalani SR; Texas Children's Hospital, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Scott TM; Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA., Scott D; Baylor Genetics Laboratories, Houston, TX, USA., Azamian MS; Baylor Genetics Laboratories, Houston, TX, USA., Louie R; Greenwood Genetic Center, Greenwood, SC, USA., Moore HW; Greenwood Genetic Center, Greenwood, SC, USA., Champaigne NL; Greenwood Genetic Center, Greenwood, SC, USA., Hollingsworth G; Greenwood Genetic Center, Greenwood, SC, USA., Torella A; Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Nigro V; Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy.; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples, Italy., Ploski R; Department of Medical Genetics, Medical University of Warsaw, Pawińskiego 3C, 02-106, Warsaw, Poland., Salpietro V; Department of Neuromuscular Disorders, Queen Square Institute of Neurology, University. College London, London, WC1N 3BG, UK.; Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, 67100, L'Aquila, Italy., Zara F; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Università Degli Studi di Genova, Genoa, Italy.; Unit of Medical Genetics, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy., Pizzi S; Molecular Genetics and Functional Genomics, Ospedale Pediatrico Bambino Gesù, IRCCS, 00146, Rome, Italy., Chillemi G; Department for Innovation in Biological, Agro-food and Forest systems, DIBAF, University of Tuscia, Via S. Camillo de Lellis s.n.c, 01100, Viterbo, Italy., Ognibene M; Unit of Medical Genetics, IRCCS Istituto Giannina Gaslini, 16147, Genoa, Italy., Cooney E; Division of Medical Genetics and Metabolism, Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA., Do J; Division of Medical Genetics and Metabolism, Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA., Linnemann A; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark., Larsen MJ; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.; Clinical Genome Center, Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Specht S; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Walters KJ; Center for Structural Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Choi HJ; School of Biological Sciences, Seoul National University, 08826, Seoul, Republic of Korea., Choi M; Department of Biomedical Sciences, Seoul National University College of Medicine, 03080, Seoul, Republic of Korea., Tartaglia M; Molecular Genetics and Functional Genomics, Ospedale Pediatrico Bambino Gesù, IRCCS, 00146, Rome, Italy., Youkharibache P; Cancer Science Data Lab, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Chae JH; Department of Genomic Medicine, Seoul National University Hospital, 03080, Seoul, Republic of Korea., Capra V; Child Neuropsychiatry, IRCCS Istituto G.Gaslini, DINOGMI University of Genova, Largo Gaslini 5, Genoa, Italy., Park SG; Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, 08826, Seoul, Republic of Korea. riceo2@snu.ac.kr., Westlake CJ; Laboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA. chris.westlake@nih.gov.

Publikováno v: Nature communications [Nat Commun] 2024 Jan 08; Vol. 15 (1), pp. 365. Date of Electronic Publication: 2024 Jan 08.

Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors.

Autor: Teuscher KB, Mills JJ, Tian J; Molecular Design and Synthesis Center, Vanderbilt Institute of Chemical Biology, Nashville, Tennessee 37232-0142, United States., Han C, Meyers KM, Sai J, South TM, Crow MM, Van Meveren M, Sensintaffar JL, Zhao B, Amporndanai K, Moore WJ; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States., Stott GM; Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21701-4907, United States., Tansey WP, Lee T, Fesik SW; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232-0142, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Dec 28; Vol. 66 (24), pp. 16783-16806. Date of Electronic Publication: 2023 Dec 12.

Identification of WD40 repeats by secondary structure-aided profile–profile alignment

Autor: Wang, Chuan, Dong, Xiaobao, Han, Lei, Su, Xiao-Dong, Zhang, Ziding, Li, Jinyan, Song, Jiangning

Publikováno v: In Journal of Theoretical Biology 7 June 2016 398:122-129

Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)-MYC Interaction.

Autor: Ding J; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Liu L; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Chiang YL; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.; Novartis Institutes for BioMedical Research, Shanghai 201203, China., Zhao M; Novartis Institutes for BioMedical Research, Shanghai 201203, China., Liu H; Novartis Institutes for BioMedical Research, Shanghai 201203, China.; Novartis Institutes for BioMedical Research, San Diego, California 92121, United States., Yang F; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Shen L; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Lin Y; Novartis Institutes for BioMedical Research, Shanghai 201203, China., Deng H; Novartis Institutes for BioMedical Research, Shanghai 201203, China., Gao J; Novartis Institutes for BioMedical Research, Shanghai 201203, China., Sage DR; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., West L; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Llamas LA; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Hao X; Novartis Institutes for BioMedical Research, Shanghai 201203, China., Kawatkar S; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Li E; Novartis Institutes for BioMedical Research, Shanghai 201203, China., Jain RK; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Tallarico JA; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Canham SM; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Wang H; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States.; Novartis Institutes for BioMedical Research, Shanghai 201203, China.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Jun 22; Vol. 66 (12), pp. 8310-8323. Date of Electronic Publication: 2023 Jun 12.