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pro vyhledávání: '"WD Repeat-Containing Protein 5"'
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Autor:
Mianxiang Li, Xiaoan Tao, Yuan He, Tong Wu, Lihong He, Juan Xia, Fan Ping, Xueyi Liang, Bin Cheng, Jian Xu, Ruoyan Cao, Zhaona Fan, Miao Deng
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 11, Pp 617-629 (2020)
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 11, Pp 617-629 (2020)
Protein arginine methyltransferase 5 (PRMT5) is an important type II arginine methyltransferase that can play roles in cancers in a highly tissue-specific manner, but its role in the carcinogenesis and metastasis of head and neck squamous cell carcin
Autor:
William G. Payne, Caden Schlund, Feng Wang, Joy Creighton, William P. Tansey, Jonathan David Macdonald, Edward T. Olejniczak, Jason Phan, Alex G. Waterson, Shaun R. Stauffer, Bin Zhao, J. Grace Shaw, Selena Chacón Simon, Lance R. Thomas, Stephen W. Fesik
Publikováno v:
Journal of Medicinal Chemistry. 63:4315-4333
The frequent deregulation of MYC and its elevated expression via multiple mechanisms drives cells to a tumorigenic state. Indeed, MYC is overexpressed in up to ∼50% of human cancers and is considered a highly validated anticancer target. Recently,
Publikováno v:
Journal of medicinal chemistry. 64(15)
WD repeat-containing protein 5 (WDR5) is a member of the WD40 protein family, and it is widely involved in various biological activities and not limited to epigenetic regulation in vivo. WDR5 is also involved in the initiation and development of many
Autor:
N. Berner, Magda Szewczyk, B. Kuester, J. Weckesser, Martin Eilers, Andreas Kraemer, Christoph A. Sotriffer, Volker Doetsch, Bikash Adhikari, Frank Loehr, Stephanie Heinzlmeir, Dalia Barsyte-Lovejoy, A. Doelle, Mathias Diebold, Elmar Wolf, J. Gerbel, Lena M. Berger, Stefan Knapp, Cheryl H. Arrowsmith
Histone H3K4 methylation serves as post-translational hallmark of actively transcribed genes and is introduced by histone methyltransferases (HMT) and its regulatory scaffolding proteins. One of these is the WD-repeat containing protein 5 (WDR5) that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bb60d0d7a9cb8061918d0989716e03b
https://doi.org/10.1101/2021.04.12.439490
https://doi.org/10.1101/2021.04.12.439490
Autor:
Yan Zhang, Lan Bai, Hongliang Li, Yan-Xiao Ji, Song Tian, Peng Zhang, Zhi-Gang She, Ye Liu, Ze-Dong Chen, Ming-Ming Chen, Xueyong Zhu
Publikováno v:
Hepatology. 70:1942-1957
Inhibition of apoptosis signal-regulating kinase 1 (ASK1) activation has emerged as a promising target for the treatment of nonalcoholic steatohepatitis (NASH). Multiple forms of posttranslational modifications determine the activity of ASK1. In addi
Autor:
Dong Li, Sitang Gong, Zhen-Li Huang, Hong Yang, Xian-Zhang Wang, Cong-Jian Zhao, Yongxuan Yao, Jin-Yan Sun, Jin-Hyun Ahn, Hui Wu, Bo Yang, Wen-Bo Zeng, Michael A. McVoy, Sheng-Nan Huang, Xue-Hui Ma, Xuan Jiang, William J. Britt, Min-Hua Luo, Shuang Cheng
Publikováno v:
J Virol
We previously reported that human cytomegalovirus (HCMV) utilizes the cellular protein WD repeat-containing protein 5 (WDR5) to facilitate capsid nuclear egress. Here, we further show that HCMV infection results in WDR5 localization in a juxtanuclear
Autor:
Jason Phan, Olivia W. Rossanese, J.G. Shaw, Chao Han, Leiber Thomas, DeMarco V. Camper, Bin Zhao, Erin R. Aho, S.W. Fesik, Joseph Alvarado, J.A. Bauer, Feng Wang, Bethany M. Alicie, Joannes P. Yuh, Jennifer E. Howes, Jonathan David Macdonald, Sameer Nikhar, Jiqing Sai, William G. Payne, S. Chacon Simon, Alex G. Waterson, Shaun R. Stauffer, William P. Tansey
Publikováno v:
Journal of medicinal chemistry. 62(24)
The treatment of tumors driven by overexpression or amplification of MYC oncogenes remains a significant challenge in drug discovery. Here, we present a new strategy toward the inhibition of MYC via the disruption of the protein-protein interaction b
Autor:
Aamir Ali, Shweta Tyagi
Publikováno v:
Journal of Biosciences. 42:155-159
WD repeat containing protein 5 (WDR5), Retinoblastoma Binding Protein 5 (RbBP5), Absent-Small-Homeotic-2- Like protein (ASH2L), and Dumpy-30 (Dpy30) have been reported to be the integral and shared components of all the SET1 family of histone 3 lysin
Autor:
Qiong Gan, Gary K. Owens, Patrick A. Grant, Pierre Thiebaud, Li Jin, Nadine Thézé, Guofeng Xu
Publikováno v:
The Journal of biological chemistry. 286(24)
WD repeat-containing protein 5 (WDR5) is a common component of mammalian mixed lineage leukemia methyltransferase family members and is important for histone H3 lysine 4 methylation (H3K4me), which has been implicated in control of activation of cell