Zobrazeno 1 - 10
of 395
pro vyhledávání: '"WD Ludwig"'
Autor:
JW Janssen, T Seriu, CR Bartram, Juerg Schwaller, A Tobler, M. Zimmermann, A. Reiter, Seisho Takeuchi, WD Ludwig, Carl W. Miller
Publikováno v:
Blood. 86:755-760
A newly recognized family of proteins that inhibit cyclin-dependent kinases (CDKs) termed cyclin-dependent kinase inhibitors (CDKI) have an important role in regulation of cell-cycle progression. A subfamily of these CDKIs (p15INK4B/MTS2, p16INK4/MTS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817c57ca1a3736597ba59f9933ded49a
https://doi.org/10.1182/blood.v86.2.755.bloodjournal862755
https://doi.org/10.1182/blood.v86.2.755.bloodjournal862755
Autor:
R H Mertelsmann, H. J. Buhring, H J Gruss, WD Ludwig, Friedhelm Herrmann, Marion A. Brach, Leonie K. Ashman
Publikováno v:
Blood. 80:1224-1230
The c-kit proto-oncogene encodes a transmembrane glycoprotein identical to the receptor for the recently cloned stem cell factor (SCF). The present study examines constitutive synthesis of transcripts in primary acute myelogenous leukemia (AML) blast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::479fdbeff16cc64fb7c99aab7c5815e2
https://doi.org/10.1182/blood.v80.5.1224.1224
https://doi.org/10.1182/blood.v80.5.1224.1224
Publikováno v:
Blood. 77:331-339
T-cell receptor (TCR) delta gene rearrangements are observed in more than 80% of acute lymphoblastic leukemia (ALL) patients. Moreover, a preferential usage of specific genetic elements has been shown in different ALL subtypes: V delta 1 DJ delta 1 r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f1ea158aeee7f433c41adaffe89dc70
https://doi.org/10.1182/blood.v77.2.331.bloodjournal772331
https://doi.org/10.1182/blood.v77.2.331.bloodjournal772331
Autor:
Mc, Bene, Bernier M, René-Olivier Casasnovas, Castoldi G, Knapp W, Lanza F, Wd, Ludwig, Matutes E, Orfao A, Sperling C, Veer Mb, T.
Publikováno v:
Europe PubMed Central
We document findings on c-kit (CD117) expression in 1,937 pediatric and adult de novo acute leukemia cases, diagnosed in five single European centers. All cases were well characterized as to the morphologic, cytochemical, and immunologic features, ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a8dee8c6d022aab0e1141d4535b69085
https://pubmed.ncbi.nlm.nih.gov/9657760
https://pubmed.ncbi.nlm.nih.gov/9657760
Publikováno v:
Europe PubMed Central
CD95 (APO-1/Fas)-mediated apoptosis is pivotal in normal lymphocyte homeostasis and mutations of CD95 cause a benign autoimmune lymphoproliferation syndrome (ALPS) in humans and mice. However, tumors only rarely develop in these patients, and no CD95
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd09b737135bf830070dfb5467c592a
https://pubmed.ncbi.nlm.nih.gov/9573033
https://pubmed.ncbi.nlm.nih.gov/9573033
Autor:
Izraeli S, Jw, Janssen, Oa, Haas, Harbott J, Brok-Simoni F, Ju, Walther, Heinrich Kovar, Henn T, Wd, Ludwig, Reiter A
Publikováno v:
Europe PubMed Central
The E2A/PBX1 and the BCR/ABL fusion genes result from the t(1;19)(q23;p13) and the t(9;22)(q34;q11), respectively, and encode oncoproteins which are thought to play an important role in the development of acute lymphoblastic leukemia (ALL) subtypes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::126eb5a1711677528638e5b0aea475c6
https://pubmed.ncbi.nlm.nih.gov/8483319
https://pubmed.ncbi.nlm.nih.gov/8483319
Publikováno v:
Cytokines in Hemopoiesis, Oncology, and AIDS II ISBN: 9783540552420
Acute myeloid leukemia (AML) is characterized by a block in differentiation of myeloid cells toward functional, end-stage hematopoietic cells. This maturational arrest can occur at various stages of differentiation. Myeloperoxidase (MPO) is the most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a53e31e779d501c48801ca631488bd31
https://doi.org/10.1007/978-3-642-48715-6_10
https://doi.org/10.1007/978-3-642-48715-6_10
Publikováno v:
Europe PubMed Central
An increasing number of papers document cases of acute leukemia in which individual blast cells co-express markers normally restricted to a single cell lineage. Numerous terms are used to refer to cases with unscheduled expression of lineage-foreign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9f2e4d2dd5c33c6259ddf2f8f4132090
https://pubmed.ncbi.nlm.nih.gov/1886419
https://pubmed.ncbi.nlm.nih.gov/1886419
Publikováno v:
Europe PubMed Central
CD95 (APO-1/Fas)-mediated apoptosis plays a major role in normal lymphocyte regulation. CD95 mutations cause a benign autoimmune lymphoproliferation syndrome (ALPS) in mice and humans. CD95 is mutated in some de novo T-lineage acute lymphoblastic leu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::87e16376fde175a0b4126b5b1d5748f7
http://europepmc.org/abstract/med/9743945
http://europepmc.org/abstract/med/9743945
Autor:
Izraeli S, Henn T, Herbert Strobl, Wd, Ludwig, Kovar H, Oa, Haas, Harbott J, Cr, Bartram, Gadner H, Lion T
Publikováno v:
Europe PubMed Central
The translocation t(1;19)(q23;p13) in pediatric patients with acute lymphoblastic leukemia (ALL) was demonstrated in early reports to result in a consistent fusion between the E2A and PBX1 gene sequences and in the expression of a uniform, chimeric E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5d98bcacb0a22df598e011a95d2926cc
http://europepmc.org/abstract/med/8255105
http://europepmc.org/abstract/med/8255105