Výsledky vyhledávání - "WB, Western blot"

Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles

Autor: Qin Xu, Bin Tu, Yongzhuo Huang, Pengfei Zhao, Huiyuan Wang, Hong Qiu, Canhao Wu, Jiaxin Zeng, Mingjie Shi

Publikováno v: Acta Pharmaceutica Sinica. B

The spread of coronavirus disease 2019 (COVID-19) throughout the world has resulted in stressful healthcare burdens and global health crises. Developing an effective measure to protect people from infection is an urgent need. The blockage of interact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7799e07530f67b3903b68db258a426
https://doi.org/10.1016/j.apsb.2021.09.004

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Hyperoside attenuates non-alcoholic fatty liver disease in rats via cholesterol metabolism and bile acid metabolism

Autor: Songsong Wang, Peng Li, Liang Zou, Jianbo Xiao, Feiya Sheng

Publikováno v: Journal of Advanced Research

Graphical abstract
Introduction Non-alcoholic fatty liver disease (NAFLD) results from increased hepatic total cholesterol (TC) and total triglyceride (TG) accumulation. In our previous study, we found that rats treated with hyperoside became re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2bd34a875a308c3012404fcb1667cc
https://doi.org/10.1016/j.jare.2021.06.001

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Intranasal temperature-sensitive hydrogels of cannabidiol inclusion complex for the treatment of post-traumatic stress disorder

Autor: Lulu Pang, Siqing Zhu, Yiguang Jin, Jinqiu Ma, Ruiteng Li, Yijing Liu, Yaxin Wang, Lin Zhu, Yi Liang, Lina Du, Xu Jin, Ge Ou

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 2031-2047 (2021)
Acta Pharmaceutica Sinica. B

Post-traumatic stress disorder (PTSD) is a psychiatric disease that seriously affects brain function. Currently, selective serotonin reuptake inhibitors (SSRIs) are used to treat PTSD clinically but have decreased efficiency and increased side effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3acddd8c0edd4a737ab5bd19ff02fe7
http://www.sciencedirect.com/science/article/pii/S2211383521000150

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Role of AMPK and Akt in triple negative breast cancer lung colonization

Autor: Heidi L. Weiss, B. Mark Evers, Jeremy Johnson, Zeta Chow, Piotr G. Rychahou, Eun Y. Lee

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 4, Pp 429-438 (2021)
Neoplasia (New York, N.Y.)

Triple negative breast cancer (TNBC) is an aggressive disease with a 5-y relative survival rate of 11% after distant metastasis. To survive the metastatic cascade, tumor cells remodel their signaling pathways by regulating energy production and upreg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f579366bddfd960dbbe114706d860b9
http://www.sciencedirect.com/science/article/pii/S1476558621000154

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Modelling diagnostics for Echinococcus granulosus surveillance in sheep using Latent Class Analysis: Argentina as a case study

Autor: Abagael L. Sykes, Edmundo Larrieu, Thelma Verónica Poggio, M. Graciela Céspedes, Guillermo B. Mujica, Maria-Gloria Basáñez, Joaquin M. Prada

Publikováno v: One Health, Vol 14, Iss, Pp 100359-(2022)
RID-UNRN (UNRN)
Universidad Nacional de Río Negro
instacron:UNRN

Fil: Sykes, Abagael. London Centre for Neglected Tropical Disease Research, Londres, Inglaterra Fil: Larrieu, Edmundo. Universidad Nacional de Rio Negro, Escuela de Veterinaria. Rio Negro, Argentina. Fil: Poggio, Veronica. Instituto Cesar Milstein, B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1266822da6d38e996a58e38bc675690
http://www.sciencedirect.com/science/article/pii/S235277142100149X

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IκB kinase-ε-mediated phosphorylation triggers IRF-1 degradation in breast cancer cells

Autor: Marta Acchioni, Anna Lisa Remoli, Angela Battistini, Robert Clarke, Chiara Acchioni, Giulia Marsili, Roberto Orsatti, Edvige Perrotti, Marco Sgarbanti

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 10, Pp 459-469 (2020)
Neoplasia (New York, N.Y.)

Interferon Regulatory Factors (IRFs) are key regulators of immunity, cell survival and apoptosis. IRF transcriptional activity and subcellular localization are tightly regulated by posttranscriptional modifications including phosphorylation. The IκB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90dc31ce8201d10ab9e5e10769229024
http://www.sciencedirect.com/science/article/pii/S1476558620301354

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Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome ActivationSummary

Autor: Naoki Minami, Hisanori Horiuchi, Kohei Wagatsuma, Daisuke Hirayama, Ryutaro Shirakawa, Tomoya Iida, Seiichi Hirota, Hiroki Ikeuchi, Minoru Matsuura, Hiroshi Nakase, Kentaro Kawakami, Masanori Nojima, Kanna Nagaishi

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 2, Pp 277-293 (2020)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Ral guanosine triphosphatase–activating protein α2 (RalGAPα2) is the major catalytic subunit of the negative regulators of the small guanosine triphosphatase Ral, a member of the Ras subfamily. Ral regulates tumorigenesis and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d16d8f812582cc3f7b9947159562783
http://www.sciencedirect.com/science/article/pii/S2352345X19301390

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An acetylation-enhanced interaction between transcription factor Sox2 and the steroid receptor coactivators facilitates Sox2 transcriptional activity and function

Autor: Jiemin Wong, Yuanyong Huang, Qingqing Guan, Jiwen Li, Li Kang, Xiaoya Duan, Lan Fang, Zhen Wang, Yimei Sun, Qiao Zhang

Publikováno v: The Journal of Biological Chemistry

Sox2 (SRY-box 2) is a transcription factor with critical roles in maintaining embryonic and adult stem cell functions and in tumorigenesis. However, how Sox2 exerts its transcriptional function remains unclear. Here we used an in vitro protein-protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc871e08c423a1d049bce37de141753
http://europepmc.org/articles/PMC8668987

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The porphyrin TMPyP4 inhibits elongation during the noncanonical translation of the FTLD/ALS-associated GGGGCC repeat in the C9orf72 gene

Autor: Christian Haass, Manabu Ikeda, Frits Kamp, Kohji Mori, Dieter Edbauer, Shinji Tagami, Yuya Kawabe, Ryota Uozumi, Yoshitaka Nagai, Brigitte Nuscher, Shiho Gotoh, Tomoko Yamashita

Publikováno v: The Journal of Biological Chemistry
The journal of biological chemistry 297(4), 101120 (2021). doi:10.1016/j.jbc.2021.101120

GGGGCC (G4C2) repeat expansion in the C9orf72 gene has been shown to cause frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Dipeptide repeat proteins produced through repeat-associated non-AUG (RAN) translation are recognized as p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76cf4c81b0c7b8cbc514811528f89f3b
http://europepmc.org/articles/PMC8446798

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Modelling diagnostics for

Autor: Abagael L, Sykes, Edmundo, Larrieu, Thelma Verónica, Poggio, M Graciela, Céspedes, Guillermo B, Mujica, Maria-Gloria, Basáñez, Joaquin M, Prada

Publikováno v: One Health

Echinococcus granulosus sensu lato is a globally prevalent zoonotic parasitic cestode leading to cystic echinococcosis (CE) in both humans and sheep with both medical and financial impacts, whose reduction requires the application of a One Health app

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8a5e52cc9e695bac9a771bf79b057b25
https://pubmed.ncbi.nlm.nih.gov/34977321

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