Výsledky vyhledávání - "WARNER, T.D."

Akademický článek

Aspirin-triggered 15-epi-lipoxin A4 predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: implications for a clinical test.

Autor: Kirkby, N.S., Chan, M.V., Lundberg, M.H., Massey, Karen A., Edmands, W.M.B., MacKenzie, L.S., Homes, E., Nicolaou, Anna, Warner, T.D., Mitchell, J.A.

Inhibition of cyclooxygenase (COX)-2 increases cardiovascular deaths. Identifying a biomarker of COX-2 is desirable but difficult, since COX-1 and COX-2 ordinarily catalyze formation of an identical product, prostaglandin H2. When acetylated by aspir

Externí odkaz: http://hdl.handle.net/10454/7247

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Akademický článek

LC-MS/MS Confirms That COX-1 Drives Vascular Prostacyclin whilst Gene Expression Pattern Reveals Non-Vascular Sites of COX-2 Expression.

Autor: Kirkby, N.S., Zaiss, A.K., Urquhart, Paula, Jiao, J., Austin, P.J., Al-Yamani, M., Lundberg, M.H., MacKenzie, L.S., Warner, T.D., Nicolaou, Anna, Herschman, H.R., Mitchell, J.A.

There are two schools of thought regarding the cyclooxygenase (COX) isoform active in the vasculature. Using urinary prostacyclin markers some groups have proposed that vascular COX-2 drives prostacyclin release. In contrast, we and others have found

Externí odkaz: http://hdl.handle.net/10454/7245

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