Active secretion and enterocytic drug metabolism barriers to drug absorption

Autor: Wacher, V. J., Salphati, L., Benet, L. Z.

Publikováno v: Advanced Drug Delivery Reviews; 2001, Vol. 46 Issue: 1-3 p89-102, 14p

Intestinal drug metabolism and antitransport processes: A potential paradigm shift in oral drug delivery

Autor: Benet, L. Z., Wu, C.-Y., Hebert, M. F., Wacher, V. J.

Publikováno v: Journal of Controlled Release; 1996, Vol. 39 Issue: 2 p139-143, 5p

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery.

Autor: Benet LZ; Department of Biopharmaceutical Sciences, University of California, San Francisco, CA 94143-0446, USA., Izumi T, Zhang Y, Silverman JA, Wacher VJ

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 1999 Nov 01; Vol. 62 (1-2), pp. 25-31.

Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics.

Autor: Wacher VJ; AvMax Inc., 890 Heinz Avenue, Berkeley, California, 94710 and Department of Biopharmaceutical Sciences, University of California, San Francisco, California 94143-0446, USA. vwacher@worldnet.att.net, Silverman JA, Zhang Y, Benet LZ

Publikováno v: Journal of pharmaceutical sciences [J Pharm Sci] 1998 Nov; Vol. 87 (11), pp. 1322-30.

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

Autor: Wacher VJ; Department of Pharmacy, University of California, San Francisco 94143-0446, USA., Wu CY, Benet LZ

Publikováno v: Molecular carcinogenesis [Mol Carcinog] 1995 Jul; Vol. 13 (3), pp. 129-34.