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Autor:
W.M. Burnham, M. Fallah
Publikováno v:
Clinical Neurophysiology. 130:e119
Background Focal Impaired Awareness Seizures of temporal lobe origin (FIAS, also called “complex partial” seizures) are the most common seizures in adults, and are typically drug resistant. Management of FIAS is clinically challenging, and new in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d47f0eb5d3eb12d3b9eedd179ba48882
https://doi.org/10.1016/j.clinph.2019.03.025
https://doi.org/10.1016/j.clinph.2019.03.025
Publikováno v:
Clinical Neurophysiology. 130:e119
Approximately 10% of the patients with long-term temporal-lobe epilepsy develop psychotic symptoms, which are known as the “psychosis of epilepsy” (POE). The relationship between the two disorders remains elusive, although they are believed to sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89c8c2ca80046ae72c20e9379b96bb87
https://doi.org/10.1016/j.clinph.2019.03.024
https://doi.org/10.1016/j.clinph.2019.03.024
Autor:
Liang Zhang, Marc-Olivier Trépanier, Richard P. Bazinet, Tariq Zahid, W.M. Burnham, Ameer Y. Taha, Tina Epps
Publikováno v:
Brain Research. 1537:9-17
Excitatory sharp waves (SPWs) originating from the hippocampus are considered to model the interictal “spikes” that occur in people with temporal lobe epilepsy. Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid that has been rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e3880ed53f58e9368a9317d29a1ad8c
https://doi.org/10.1016/j.brainres.2013.09.004
https://doi.org/10.1016/j.brainres.2013.09.004
Publikováno v:
Clinical Neurophysiology. 129:e45
Patients with focal temporal lobe seizures often experience transient episodes of impaired awareness with behavioural arrest, but the precise mechanism remains unknown. The Blumenfeld hypothesis attributes these deficits to a loss of cholinergic inpu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6b0df2d7d62896267c1fb02f9c6515a
https://doi.org/10.1016/j.clinph.2018.03.027
https://doi.org/10.1016/j.clinph.2018.03.027
Publikováno v:
Epilepsy & Behavior. 17:336-343
Objective Docosahexaenoic acid (DHA), an omega-3 fatty acid, has been reported to raise seizure thresholds. The purpose of the present study was to test the acute anticonvulsant effects of unesterified DHA in rats, using the maximal pentylenetetrazol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510217cf15e0195c510fb54621bc3f48
https://doi.org/10.1016/j.yebeh.2010.01.001
https://doi.org/10.1016/j.yebeh.2010.01.001
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 72:1191-1200
Polyunsaturated fatty acids (PUFA), at high doses, have been demonstrated to possess anticonvulsant properties in animal seizure models. Little is known, however, about the possible metabolic or adverse effects of PUFA at these high, anticonvulsant d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c85c9e2f1f857fc076af9d40584858d
https://doi.org/10.1080/15287390903091889
https://doi.org/10.1080/15287390903091889
Autor:
Kirk Nylen, W.M. Burnham, Miguel A. Cortez, Jose Luis Perez Velazquez, Khosrow Adeli, Sergei S. Likhodii, Lily Shen, K. Michael Gibson, Yevgen Leshchenko, O. Carter Snead
Publikováno v:
Experimental Neurology. 210:449-457
Succinic semialdehyde dehydrogenase (SSADH) deficiency is a heritable disorder of GABA degradation characterized by ataxia, psychomotor retardation and seizures. To date, there is no effective treatment for SSADH deficiency. We tested the hypothesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b728f7fe5470d4b3b6498582c5d45504
https://doi.org/10.1016/j.expneurol.2007.11.015
https://doi.org/10.1016/j.expneurol.2007.11.015
Autor:
Deborah Lonsdale, W.M. Burnham
Publikováno v:
Neuroscience Letters. 411:147-151
It has long been known that the steroid hormone progesterone has anticonvulsant actions. These have been documented both in animals and humans. In 2003, we reported that progesterone's first metabolite, 5alpha-dihydroprogesterone (5alpha-DHP), has st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137d5c974b3905654a427530eeb1d763
https://doi.org/10.1016/j.neulet.2006.10.023
https://doi.org/10.1016/j.neulet.2006.10.023
Autor:
Richard P. Bazinet, Kei-Man Kwong, Marc-Olivier Trépanier, Chuck T. Chen, W.M. Burnham, Anthony F. Domenichiello
Publikováno v:
Epilepsybehavior : EB. 50
Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid (n − 3 PUFA) that has been shown to raise seizure thresholds in the maximal pentylenetetrazole model following acute subcutaneous (s.c.) administration in rats. Following s.c. admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3efee14375ade46f1cac355147a69f0d
https://pubmed.ncbi.nlm.nih.gov/26141815
https://pubmed.ncbi.nlm.nih.gov/26141815