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Western-style diet, with and without chronic androgen treatment, alters the number, structure, and function of small antral follicles in ovaries of young adult monkeys

Autor: Jon D. Hennebold, Jing Xu, Fuhua Xu, Etienne Galbreath, Mary B. Zelinski, Alison Y. Ting, Cecily V. Bishop, W.K. McGee, Richard L. Stouffer, Judy L. Cameron

Publikováno v: Fertility and Sterility. 105:1023-1034

To examine the small antral follicle (SAF) cohort in ovaries of adult rhesus monkeys after consumption of a Western-style diet (WSD), with or without chronically elevated androgen levels since before puberty.Cholesterol or T (n = 6 per group) implant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb36e9734387a227a1c55e610f901074
https://doi.org/10.1016/j.fertnstert.2015.11.045

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Exposure of Female Macaques to Western-Style Diet With or Without Chronic T In Vivo Alters Secondary Follicle Function During Encapsulated 3-Dimensional Culture

Autor: Byung Park, Jing Xu, Richard L. Stouffer, W.K. McGee, Judy L. Cameron, Mary B. Zelinski, Cecily V. Bishop

Publikováno v: Endocrinology. 156:1133-1142

Increased adiposity and hyperandrogenemia alter reproductive parameters in both animal models and women, but their effects on preantral follicles in the ovary remain unknown. We recently reported that Western-style diet (WSD) consumption over 1 year,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6bfcb0360dcb0f71d3c2b9d9a8f59c
https://doi.org/10.1210/en.2014-1711

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Elevated androgens during puberty in female rhesus monkeys lead to increased neuronal drive to the reproductive axis: a possible component of polycystic ovary syndrome

Autor: C.R. Pohl, R.J. Chang, W.K. McGee, Judy L. Cameron, John C. Marshall, Cecily V. Bishop, Francis K.-Y. Pau, Alistair Bahar, Richard L. Stouffer

Publikováno v: Human Reproduction. 27:531-540

Hyperandrogenemia is associated with several clinical disorders in which both reproductive dysfunction and metabolic changes may coexist [i.e. polycystic ovary syndrome (PCOS), obesity and congenital adrenal hyperplasia]. Moreover, there is growing e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25b4a1506460b60f4867fe145c961b3
https://doi.org/10.1093/humrep/der393

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Effects of hyperandrogenemia and increased adiposity on reproductive and metabolic parameters in young adult female monkeys

Autor: Francis K.-Y. Pau, R.J. Chang, W.K. McGee, J. L. Cameron, Richard L. Stouffer, C. R. Pohl, Cecily V. Bishop, John C. Marshall

Publikováno v: American journal of physiology. Endocrinology and metabolism. 306(11)

Many patients with hyperandrogenemia are overweight or obese, which exacerbates morbidities associated with polycystic ovary syndrome (PCOS). To examine the ability of testosterone (T) to generate PCOS-like symptoms, monkeys received T or cholesterol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e017678bf7200b09d7791d4e3e851189
https://pubmed.ncbi.nlm.nih.gov/24735887

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Ovarian Cycle-Specific Regulation of Adipose Tissue Lipid Storage by Testosterone in Female Nonhuman Primates

Autor: Robert W. O’Rourke, Charles T. Roberts, W.K. McGee, Michael P. Chu, Richard L. Stouffer, Kevin A. Meyer, Judy L. Cameron, Oleg Varlamov, Cecily V. Bishop

Previous studies in rodents and humans suggest that hyperandrogenemia causes white adipose tissue (WAT) dysfunction in females, although the underlying mechanisms are poorly understood. In light of the differences in the length of the ovarian cycle b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8afcc81145b909715a16d9f78267b40
https://europepmc.org/articles/PMC3800767/

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