Zobrazeno 1 - 10
of 34
pro vyhledávání: '"W.K. Alderton"'
Autor:
Angeleen Fleming, W.K. Alderton
Publikováno v:
Drug Discovery Today: Disease Models. 10:e43-e50
The growing literature on zebrafish disease models and drug safety assessment suggests this organism may have utility in the drug discovery process. Over the past seven years, 24 zebrafish papers have been published with co-authors from pharmaceutica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d751dad642467abba54030161fcce3a4
https://doi.org/10.1016/j.ddmod.2012.02.006
https://doi.org/10.1016/j.ddmod.2012.02.006
Autor:
William S. Redfern, J.-P. Valentin, Thomas H. Hutchinson, G.M. Kimber, Matthew J. Winter, I. Strang, W.K. Alderton, Frances M. Richards, Z. Liu
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 58:50-58
Introduction The use of zebrafish (Danio rerio) larvae was investigated to predict adverse visual effects and to establish the potential application of this organism in early drug safety assessment. Methods Following a comparison of the effects of 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73024db4c1e9d86933a38f72074eff9
https://doi.org/10.1016/j.vascn.2008.04.002
https://doi.org/10.1016/j.vascn.2008.04.002
Autor:
Paul Goldsmith, Stephane Berghmans, Iain Gardner, Frances M. Richards, Gillian Kimber, W.K. Alderton, Alan Geoffrey Roach, Angeleen Fleming, Paul Butler, Gareth Waldron, Zoe Golder
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 58:59-68
Introduction Safety pharmacology is integral to the non-clinical safety assessment of new chemical entities prior to first administration to humans. The zebrafish is a well established model organism that has been shown to be relevant to the study of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d1a4071d95a6718043b74d05b63cb7
https://doi.org/10.1016/j.vascn.2008.05.130
https://doi.org/10.1016/j.vascn.2008.05.130
Publikováno v:
Drugs of the Future. 41:311
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc7ce65cf3d4dc740a9f8040b5557128
https://doi.org/10.1358/dof.2016.041.05.2483536
https://doi.org/10.1358/dof.2016.041.05.2483536
Autor:
Stephane Berghmans, Frances M. Richards, W.K. Alderton, Angeleen Fleming, Paul Butler, Zoe Golder, H. Chassaing, Iain Gardner
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 40(8)
This study examined the accumulation and metabolism of a number of drugs and commonly used probes for human cytochrome P450s (CYPs) in zebrafish larvae under conditions relevant to pharmacological and toxicological assays. Studies with cisapride, chl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd06cb5e398182a5b670763e079c1cf
https://pubmed.ncbi.nlm.nih.gov/20528625
https://pubmed.ncbi.nlm.nih.gov/20528625
Publikováno v:
Glia.
Knowledge of the precise timing of myelination is critical to the success of zebrafish-based in vivo screening strategies for potential remyelination therapies. This study provides a systematic review of the timing of myelination in the zebrafish spi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468feb6fec3aab61b5778f8a8073b36c
https://doi.org/10.1002/glia.20964
https://doi.org/10.1002/glia.20964
Autor:
Zoe Golder, Stephane Berghmans, Paul Butler, Angeleen Fleming, W.K. Alderton, Alan Geoffrey Roach, Teresa P. Barros, Iain Gardner, A. Hill
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 58:177-178
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61d51a5e3109367ecc047eebb367715a
https://doi.org/10.1016/j.vascn.2008.05.128
https://doi.org/10.1016/j.vascn.2008.05.128
Autor:
P. Depledge, S. Shuttleworth, N. Saghir, Florence I. Raynaud, N.C. Wan, W.K. Alderton, A.J. Folkes, N. Wan, G. Pergl-Wilson, N.S.S. Saghir, K. Ahmadi, I.S. Chuckowree, A. Zhyvoloup
Publikováno v:
European Journal of Cancer Supplements. 2:97-98
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02cd33351fc8c04fa0b71a5cd22420d0
https://doi.org/10.1016/s1359-6349(04)80328-8
https://doi.org/10.1016/s1359-6349(04)80328-8
Publikováno v:
Drugs of the Future. 37:225
Dr. Mark Mulvihill (OSI Pharmaceuticals) described the discovery and development of linsitinib (OSI-906), a potent and highly selective dual inhibitor of insulin-like growth factor 1 receptor (IGF-I receptor) and insulin receptor (IR) signaling, curr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d74e098869578e232949a79b677fdb
https://doi.org/10.1358/dof.2012.037.03.1782930
https://doi.org/10.1358/dof.2012.037.03.1782930
Autor:
H M Reynolds, Stephane Berghmans, Alan Geoffrey Roach, Teresa P. Barros, S. Clarke, W.K. Alderton
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 58:150
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b48d834a8fc1559f88f3295cc44df5a6
https://doi.org/10.1016/j.vascn.2008.05.021
https://doi.org/10.1016/j.vascn.2008.05.021