Výsledky vyhledávání - "W.J Tamminga"

Inhibitory Effect of Telmisartan on the Blood Pressure Response to Angiotensin II Challenge

Autor: Thomas Meinicke, Henrieke de Bruin, Jan J. van Lier, Joachim Stangier, Pauline N. M. Van Heiningen, W.J Tamminga, Chung‐An P. F. Su, Jan H. G. Jonkman

Publikováno v: Journal of Cardiovascular Pharmacology. 38:672-685

Telmisartan is a new angiotensin receptor antagonist possessing potent, selective, and insurmountable inhibitory activity specific to the angiotensin II type 1 (AT 1 ) receptor. The current study was performed to determine the inhibition of the angio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec233a175038d61c66576130a0d3ac60
https://doi.org/10.1097/00005344-200111000-00004

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An optimized methodology for combined phenotyping and genotyping on CYP2D6 and CYP2C19

Autor: Jan P. G. Brakenhoff, Lou F. M. H. de Leij, Mireille G. F. Gerrits, Rokus A. de Zeeuw, Johan Wemer, W.J Tamminga, Jan H.G. Jonkman, B. Oosterhuis

Publikováno v: European Journal of Clinical Pharmacology. 57:143-146

A method for simultaneous phenotyping and genotyping for CYP2D6 and CYP2C19 was tested. Six healthy volunteers were selected (three extensive and three poor metabolisers for CYP2D6). CYP2D6 was probed with dextromethorphan and metoprolol and CYP2C19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51f8ed1f41e693ccdb41d72cdafc17b
https://doi.org/10.1007/s002280100273

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Absorption, Metabolism, and Excretion of Intravenously and Orally Administered [ 14 C]Telmisartan in Healthy Volunteers

Autor: Sjoerd P. van Marle, Frans A. E. Sollie, Jochen Schmid, Heinz Switek, Aalt Verhagen, Jan H. G. Jonkman, W.J Tamminga, Dietrich Türck, Pierre Peeters, Joachim Stangier

Publikováno v: The Journal of Clinical Pharmacology. 40:1312-1322

The study was conducted in healthy male volunteers to evaluate the absorption, metabolic pattern, and mode of elimination of telmisartan, a nonpeptide angiotensin II receptor antagonist. [14C]telmisartan was administered orally in solution as a singl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15b8d6073dee3364a1a059aa6073c85f
https://doi.org/10.1177/009127000004001202

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[Untitled]

Autor: Jaap Wieling, W.J Tamminga, B. Oosterhuis, Johan Wemer, Jan H.G. Jonkman, E.P Sakiman

Publikováno v: Therapeutic Drug Monitoring. 22:486-496

A bioanalytical method for the determination of dextromethorphan (DEX) and its metabolites dextrorphan (DTX), 3-methoxymorphinan (3MM), and 3-hydroxymorphinan (3HM) in human urine was developed for CYP2D6 phenotyping and CYP3A4 activity measurements

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e59e2c7575d61105c010a98895b681c
https://doi.org/10.1097/00007691-200008000-00020

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Dopamine D2R Agonist-Induced Cardiovascular Effects in Healthy Male Subjects: Potential Implications in Clinical Settings

Autor: Izaak den Daas, W.J Tamminga, Sandra van Os, Corine Baljé-Volkers, Khalid Abou Farha

Publikováno v: ISRN Neurology

Dopamine D2 receptor agonists represent a first line treatment option in young patients with signs and symptoms of idiopathic Parkinson's disease. An association between the use of D2 receptor agonists in Parkinson's disease patients and heart failur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165b8c106c9f0402ceda6f577849879e
https://pubmed.ncbi.nlm.nih.gov/24587918

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Polymorphic drug metabolism (CYP2D6) and utilisation of psychotropic drugs in hospitalised psychiatric patients: a retrospective study

Autor: Stan Vranckx, Anthonius de Boer, Rokus A. de Zeeuw, Jan H.G. Jonkman, W.J Tamminga, Johan Wemer, Lou F. M. H. de Leij, B. Oosterhuis, Ben F. H. Drenth

Publikováno v: European journal of clinical pharmacology. 59(1)

The aim of the current retrospective study was to assess the influence of polymorphic drug metabolism as assessed by genotyping, on the on the utilisation of psychotropic drugs in hospitalised psychiatric patients. The utilisation of psychotropic dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae57ca1566094d9bc7f2d1de1e986e0
https://pubmed.ncbi.nlm.nih.gov/12743673

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The prevalence of CYP2D6 and CYP2C19 genotypes in a population of healthy Dutch volunteers

Autor: W.J Tamminga, B. Oosterhuis, Jan H.G. Jonkman, Johan Wemer, R.A. de Zeeuw, L. de Leij

Publikováno v: European Journal of Clinical Pharmacology, 57(10), 717-722. Springer Verlag

Aim: This study was performed in a sample of the Dutch population to estimate the prevalence of noncoding mutations of CYP2D6 and CYP2C19 as obtained by genotyping. In addition, the predictability of the genotyping strategy was assessed.Methods: The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41c064c12ab0f35144ac671b85ff130
https://pubmed.ncbi.nlm.nih.gov/11829201

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Mephenytoin as a probe for CYP2C19 phenotyping:effect of sample storage, intra-individual reproducibility and occurrence of adverse events

Autor: Daan J Touw, B. Oosterhuis, Lou F. M. H. de Leij, Johan Wemer, Jaap Wieling, W.J Tamminga, Jan H.G. Jonkman, Rokus A. de Zeeuw

Publikováno v: British Journal of Clinical Pharmacology, 51(5), 471-474. Wiley

Aims To further evaluate mephenytoin as a probe for CYP2C19 phenotyping.Methods Healthy subjects (n=2638) were phenotyped using the urinary (S)-mephenytoin to (R)-mephenytoin ratio. This method was evaluated for (a) the stability of the S/R-ratio fol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecee286b865671d4ce717e2ba40d8aa4
https://pubmed.ncbi.nlm.nih.gov/11422005

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CYP2D6 and CYP2C19 activity in a large population of Dutch healthy volunteers: indications for oral contraceptive-related gender differences

Autor: Jan H.G. Jonkman, W.J Tamminga, B. Oosterhuis, Bob Wilffert, Lou F. M. H. de Leij, Johan Wemer, Jaap Wieling, R.A. de Zeeuw

Publikováno v: European Journal of Clinical Pharmacology, 55(3), 177-184. Springer Verlag

We examined a large database containing results on CYP2D6 and CYP2C19 activity of 4301 Dutch volunteers phenotyped in the context of various clinical pharmacology studies.The subjects were given 22 mg dextromethorphan, 100 mg mephenytoin and 200 mg c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b6e8f269dc45dfcf9902ddcc0bd324b
https://research.rug.nl/en/publications/3806895d-da88-4a25-b739-ee1db11bdabd

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Rational experimental design for bioanalytical methods validation. Illustration using an assay method for total captopril in plasma

Autor: J. Hempenius, W.J Tamminga, J. Wieling, B. Oosterhuis, G. Hendriks, C.K. Mensink, Jan H.G. Jonkman

Publikováno v: Journal of chromatography. A. 730(1-2)

Generally, bioanalytical chromographic methods are validated according to a predefined programme and distinguish a pre-validation phase, a main validation phase and a follow-up validation phase. In this paper, a rational, total performance evaluation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfed3680a07ae64b8457f7d767131464
https://pubmed.ncbi.nlm.nih.gov/8680594

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