Výsledky vyhledávání

Intraspinal administration of an antibody against CD81 enhances functional recovery and tissue sparing after experimental spinal cord injury

Autor: Peter R. Bär, W.H. Gispen, Eldon E. Geisert, S. Dijkstra, Alex J. Lankhorst, Frank P.T. Hamers, Elbert A.J. Joosten, Simone E.J. Duis, I.M. Pans, H. Veldman

Publikováno v: Experimental Neurology. 202:57-66

We previously demonstrated that the tetraspanin protein CD81 is up-regulated by astrocytes and microglia after traumatic spinal cord injury in rats and that CD81 is involved in adhesion and proliferation of cultured astrocytes and microglia. Since th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bb402530702da21459181a67cd4b8d
https://doi.org/10.1016/j.expneurol.2006.05.011

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Insulin inhibits extracellular regulated kinase 1/2 phosphorylation in a phosphatidylinositol 3-kinase (PI3) kinase-dependent manner in Neuro2a cells

Autor: W.H. Gispen, Marco F.M. Hoekman, L. P. Van Der Heide, Geert Jan Biessels

Publikováno v: Journal of Neurochemistry. 86:86-91

Insulin signalling is well studied in peripheral tissue, but not in neuronal tissue. To gain more insight into neuronal insulin signalling we examined protein kinase B (PKB) and extracellular regulated kinase 1 and 2 (ERK1/2) regulation in serum-depr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5a87e9882c52bbc2b815622f8413f88
https://doi.org/10.1046/j.1471-4159.2003.01828.x

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Activation of pre- and postsynaptic protein kinase C during tetraethylammonium-induced long-term potentiation in the CA1 field of the hippocampus

Autor: Annemarie van der Slot, Moniek van Beest, Piera Pasinelli, W.H. Gispen, Geert M.J. Ramakers, Pierre N. E. De Graan

Publikováno v: Neuroscience letters, 286(1), 53. Elsevier

Tetraethylammonium (TEA) induces a form of long-term potentiation (LTP) that is independent on N -methyl- d -aspartate (NMDA) receptor activation (LTP K ). LTP K may be a suitable chemical model to study molecular mechanisms underlying LTP. We monito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6acada6185a36ee644576f9c5c30aa3
https://doi.org/10.1016/s0304-3940(00)01081-8

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Nerve Function and Oxidative Stress in Diabetic and Vitamin E-Deficient Ratsfn1fn1Grant support: Diabetes Fonds Nederland

Autor: J. J. M. Marx, P. S. Van Dam, W.H. Gispen, Bert Bravenboer, B. S. Van Asbeck, J. F. L. M. Van Oirschot

Publikováno v: Free Radical Biology and Medicine. 24:18-26

Nerve dysfunction in diabetes is associated with increased oxidative stress. Vitamin E depletion also leads to enhanced presence of reactive oxygen species (ROS). We compared systemic and endoneurial ROS activity and nerve conduction in vitamin E-dep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb9b1f1d0b7005891955ba4acb27c412
https://doi.org/10.1016/s0891-5849(97)00122-6

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[Untitled]

Autor: Roger A.H. Adan, Julia Oosterom, Rob H. Meloen, W.H. Gispen, W.M.M. Schaaper, Truus A. Posthuma

Publikováno v: Letters in Peptide Science. 5:205-208

Cyclic lactam analogs of α-melanocyte stimulating hormone (α-MSH) have been shown to be potent agonists in the frog skin bioassay [Al-Obeidi, F. et al., J. Med. Chem., 32 (1989) 2555], demonstrating melanocortin-1 (MC1) receptor activity. We synthe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44c32564e904796641b81bd9bb450762
https://doi.org/10.1023/a:1008877507882

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Ultrastructural co-localization of calmodulin and B-50/growth-associated protein-43 at the plasma membrane of proximal unmyelinated axon shafts studied in the model of the regenerating rat sciatic nerve

Autor: A.J. Verkleij, W.H. Gispen, Paul Verkade, A.B. Oestreicher, L.H. Schrama

Publikováno v: Neuroscience. 79:1207-1218

Calmodulin and de-phosphorylated B-50/growth-associated protein-43 (GAP-43) have been shown to bind in vitro in a molecular complex, but evidence for an in situ association in the nervous system does not exist. Previously, we have reported that, in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3911ba35a252585142b218069a1cc4
https://doi.org/10.1016/s0306-4522(97)00041-9

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Beneficial Effects of the Melanocortin ??-Melanocyte-stimulating Hormone on Clinical and Neurophysiological Recovery after Experimental Spinal Cord Injury

Autor: Alex J. Lankhorst, E.A.J. Joosten, H. van de Meent, W.H. Gispen, Frank P.T. Hamers

Publikováno v: Neurosurgery. 40:122-131

OBJECTIVE Melanocortins, peptides related to melanocyte-stimulating hormone (MSH) and corticotropin (ACTH), exhibit neurotrophic and neuroprotective activity in several established models of peripheral and central nervous system damage. The beneficia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc475e2f24c28f11775adb244cf6432
https://doi.org/10.1097/00006123-199701000-00028

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