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Akademický článek

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Genomic instability in bone marrow failure syndromes

Autor: Joanne F. Sutton, Jaroslaw P. Maciejewski, Johnson M. Liu, W.G. Kearns, Neal S. Young

Publikováno v: American Journal of Hematology. 76:220-224

Aneuploidy is frequently seen in leukemia and myelodysplasia (MDS) but was thought to be uncommon in aplastic anemia (AA). We examined marrow cells from 96 unselected patients with bone marrow failure syndromes to assess the frequency of undetected a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7325988b8533c349f49b5c5e99c32f
https://doi.org/10.1002/ajh.20101

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Centrosome amplification and aneuploidy in bone marrow failure patients

Autor: Johnson M. Liu, Neal S. Young, W.G. Kearns, Hiroki Yamaguchi

Publikováno v: Genes, Chromosomes and Cancer. 40:329-333

Patients with bone marrow failure are at risk for development of hematopoietic progenitor clones with abnormal numbers of chromosomes (aneuploidy) and leukemia. Numerical centrosome abnormalities or mutations in genes associated with the mitotic spin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6873d4d436b678396ec956af3b936e
https://doi.org/10.1002/gcc.20043

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Increased risk for aplastic anemia and myelodysplastic syndrome in individuals lacking glutathione S-transferase genes

Autor: Neal S. Young, Michael W. Stacey, W.G. Kearns, Joanne F. Sutton, Johnson M. Liu, Thomas S. Rieg

Publikováno v: Pediatric Blood & Cancer. 42:122-126

Background Aplastic anemia (AA) and myelodysplastic syndrome (MDS) are marrow failure states that may be associated with chromosomal instability. An absence of the glutathione S-transferase (GST) enzyme may genetically predispose individuals to AA or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfb00cc541a7072d125f60e11c2cb5ef
https://doi.org/10.1002/pbc.10479

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Absence of donor-derived keratinocyte stem cells in skin tissues cultured from patients after mobilized peripheral blood hematopoietic stem cell transplantation

Autor: Cristian Carvallo, Carole Yee, Michael R. Albert, Peiman Hematti, Richard W. Childs, Cynthia E. Dunbar, J. Barrett, Jonathan C. Vogel, Monika M Fuehrer, Jan Blancato, Elaine M. Sloand, W.G. Kearns

Publikováno v: Experimental Hematology. 30:943-949

Objective Recent studies suggest that primitive bone marrow-derived cells contribute to regeneration of many tissues, including muscle, endothelium, myocardium, neural tissues, liver, and skin. Conversely, primitive cells resident in muscle and other

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b9168072033b81ab6f7fb0c08b6313
https://doi.org/10.1016/s0301-472x(02)00873-1

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Aneuploidy frequencies in semen fractions from ten oligoasthenoteratozoospermic patients donating sperm for intracytoplasmic sperm injection

Autor: Michael W. Stacey, Jacob F. Mayer, Jerome Pfeffer, Stanton F. Hoegerman, C. Osgood, Sergio Oehninger, Myung-Geol Pang, W.G. Kearns

Publikováno v: Fertility and Sterility. 72:472-478

Objective: To determine aneuploidy frequencies in pellet and swim-up semen fractions from 10 infertile men with severe oligoasthenoteratozoospermia (OAT) who were donating sperm for intracytoplasmic sperm injection and to determine whether the swim-u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7582f60901d1a31424edbf11d3875e
https://doi.org/10.1016/s0015-0282(99)00279-4

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Akademický článek

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Nuclear receptor co-repressor gene localizes to 17p11.2, a frequently deleted band in malignant disorders

Autor: Michael W. Stacey, Rebecca L. Byrd, Jianxiang Wang, W.G. Kearns, Johnson M. Liu

Publikováno v: Genes, Chromosomes and Cancer. 25:191-193

The t(8;21) between the AML1 and ETO genes is a commonly seen genetic alteration in acute myeloid leukemia. Recently, we reported that the fusion partner ETO binds to the human nuclear receptor co-repressor (NCOR), a member of the NCOR/SIN3/histone d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4e74d26793cdd6126b1a3b329fc8482
https://doi.org/10.1002/(sici)1098-2264(199906)25:2<191::aid-gcc16>3.0.co

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Comparative cytogenetic analysis between cyclophosphamide-sensitive and -resistant lines of acute myeloid leukemia in the lewis brown norway hybrid rat

Autor: W.G. Kearns, Todd M. Koelling, Andrew M. Yeager

Publikováno v: Genes, Chromosomes and Cancer. 2:290-295

An animal model of acute myeloid leukemia (AML) has been developed in the Brown Norway (BN) rat and has successfully been introduced into the Lewis x BN F1 hybrid (LBN) and designated LBN AML. The original LBN AML is sensitive to the chemotherapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f8b997a86a6cc2dab6aec405b3b42a
https://doi.org/10.1002/gcc.2870020406

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