Zobrazeno 1 - 10
of 38
pro vyhledávání: '"W.C. Hardwick"'
Publikováno v:
Pharmacology Biochemistry and Behavior. 90:382-386
Pigeons are used frequently as subjects in behavioral pharmacology research. An advantage of the pigeon is an exceedingly vascular breast muscle, which is easily accessible for injections. The purpose of these studies was to provide a profile of the
Publikováno v:
Pharmacology Biochemistry and Behavior. 68:395-402
Pigeons were trained to discriminate among 5 mg/kg pentobarbital, 5 mg/kg morphine, and saline when responding was maintained under fixed-interval (FI) or fixed-ratio (FR) reinforcement schedules. After the discrimination was established, other drugs
Discriminative Stimulus Effects and Antipunishment Effects of Drugs Measured During the Same Session
Publikováno v:
Pharmacology Biochemistry and Behavior. 56:161-166
The effects of pentobarbital, diazepam, phencyclidine, buspirone and methamphetamine on drug discrimination and on responding under a variable-interval variable-interval with punishment schedule were studied in pigeons trained to discriminate 5.0 mg/
Publikováno v:
Pharmacology Biochemistry and Behavior. 48:941-957
Rats trained to hold a lever down for at least 1.0 s but less than 1.3 s could differentiate the reinforced response duration on about 50% of the trials. The response duration frequency distribution was a normal distribution with a peak near the mini
Autor:
C. J. Hall, Melinda G. Gunnell, J. R. Daniels, Mi Li, Donald E. McMillan, Sarah M. Owens, William D. Wessinger, W.C. Hardwick
Publikováno v:
Psychopharmacology. 185(1)
Drug-specific monoclonal antibodies against phencyclidine (PCP) and (+)-methamphetamine [(+)-METH] should bind to these drugs to block their discriminative stimulus effects. To determine if mouse monoclonal antibodies against PCP and (+)-METH can blo
Autor:
D.E., McMillan, W.C., Hardwick
Publikováno v:
Behavioural pharmacology. 7(3)
Pigeons were trained to discriminate 5mg/kg pentobarbital from saline under several multiple fixed-ratio fixed-interval schedules of food presentation. The following schedules were studied: multiple fixed-ratio 40 fixed-interval 18s (mult FR40 FI18),
Publikováno v:
Drug and alcohol dependence. 40(1)
Rats from the University of Indiana lines bred to accept ethanol (P rats) and not to accept ethanol (NP rats) were divided into two groups of 3 rats per group. The first group of P and NP rats was given free access to food, water and 5% (w/v) ethanol
Autor:
D.E., McMillan, W.C., Hardwick
Publikováno v:
Behavioural pharmacology. 2(4 And 5)
An attempt was made to train pigeons to discriminate phencyclidine (PCP) from saline using a three-key color-tracking procedure under which birds were trained under a second order schedule [FR10 (FR5)] "without errors." Training without errors was do
Publikováno v:
Pharmacology, biochemistry, and behavior. 35(4)
Phencyclidine (PCP) pharmacokinetics and drug discrimination were examined in pigeons (n = 6 in both groups) after intramuscular doses of 1.48 mg/kg. PCP absorption was rapid with maximum measured plasma concentrations ranging from 559 to 1450 ng/ml
Publikováno v:
Pharmacology, biochemistry, and behavior. 25(1)
Plasma phencyclidin levels were determined in pigeons trained to discriminate 1.5 mg/kg phencyclidine from saline under a second-order schedule using a color-tracking procedure. With both cumulative and non-cumulative dosing procedures, pigeons relia