Výsledky vyhledávání - "W. van den Heuvel"

Akademický článek

Effects of allopurinol and febuxostat on uric acid transport and transporter expression in human umbilical vein endothelial cells.

Autor: Karel H van der Pol, Jan Koenderink, Jeroen J M W van den Heuvel, Petra van den Broek, Janny Peters, Imke D W van Bunningen, Jeanne Pertijs, Frans G M Russel, Jim Koldenhof, Wim J Morshuis, Joris van Drongelen, Tom J J Schirris, Andries van der Meer, Gerard A Rongen

Publikováno v: PLoS ONE, Vol 19, Iss 6, p e0305906 (2024)

Uric acid induces radical oxygen species formation, endothelial inflammation, and endothelial dysfunction which contributes to the progression of atherosclerosis. Febuxostat inhibits BCRP- and allopurinol stimulates MRP4-mediated uric acid efflux in

Externí odkaz: https://doaj.org/article/fd27e0ee1021449984bd8991649ed5a0

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Perfluoroalkyl substances (PFASs) are substrates of the renal human organic anion transporter 4 (OAT4)

Autor: Jochem Louisse, Luca Dellafiora, Jeroen J. M. W. van den Heuvel, Deborah Rijkers, Liz Leenders, Jean-Lou C. M. Dorne, Ans Punt, Frans G. M. Russel, Jan B. Koenderink

Publikováno v: Archives of Toxicology, 97, 3, pp. 685-696
Archives of Toxicology 97 (2023) 3
Archives of Toxicology, 97(3), 685-696
Archives of Toxicology, 97, 685-696

Contains fulltext : 291310.pdf (Publisher’s version ) (Open Access) Poly- and perfluoroalkyl substances (PFASs) are omnipresent in the environment and have been shown to accumulate in humans. Most PFASs are not biotransformed in animals and humans,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a27e391e6bed55ba30277471e5341f
https://hdl.handle.net/2066/291310

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Akademický článek

The Shiga Toxin Receptor Globotriaosylceramide as Therapeutic Target in Shiga Toxin E. coli Mediated HUS

Autor: Wouter J. C. Feitz, Romy Bouwmeester, Thea J. A. M. van der Velden, Susan Goorden, Christoph Licht, Lambert P. J. W. van den Heuvel, Nicole C. A. J. van de Kar

Publikováno v: Microorganisms, Vol 9, Iss 10, p 2157 (2021)

In 90% of the cases, childhood hemolytic uremic syndrome (HUS) is caused by an infection with the Shiga toxin (Stx) producing E. coli bacteria (STEC-HUS). Stx preferentially binds to its receptor, the glycosphingolipid, globotriaosylceramide (Gb3), p

Externí odkaz: https://doaj.org/article/494af96ddb7a437ba2b31e387ac46ae3

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Akademický článek

Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates

Autor: Maarten van der Velden, Albert Bilos, Jeroen J. M. W. van den Heuvel, Sanna R. Rijpma, Evelien G. E. Hurkmans, Robert W. Sauerwein, Frans G. M. Russel, Jan B. Koenderink

Publikováno v: Malaria Journal, Vol 16, Iss 1, Pp 1-12 (2017)

Abstract Background Malaria, HIV/AIDS, and tuberculosis endemic areas show considerable geographical overlap, leading to incidence of co-infections. This requires treatment with multiple drugs, potentially causing adverse drug–drug interactions (DD

Externí odkaz: https://doaj.org/article/b27f86145f49479db057cc1f0f96e3c4

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Akademický článek

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Akademický článek

Completing the Enalaprilat Excretion Pathway—Renal Handling by the Proximal Tubule

Autor: Nori J. L. Smeets, Carlijn H. C. Litjens, Jeroen J. M. W. van den Heuvel, Hedwig van Hove, Petra van den Broek, Frans G. M. Russel, Jan B. Koenderink, Saskia N. de Wildt

Publikováno v: Pharmaceutics, Vol 12, Iss 10, p 935 (2020)

Background: Enalapril is often used in the treatment of cardiovascular diseases. Clinical data suggest that the urinary excretion of enalaprilat, the active metabolite of enalapril, is mediated by renal transporters. We aimed to identify enalaprilat

Externí odkaz: https://doaj.org/article/044f751e0f7e4c77bcf1c387e2aa60ef

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Akademický článek

Primary Human Derived Blood Outgrowth Endothelial Cells: An Appropriate In Vitro Model to Study Shiga Toxin Mediated Damage of Endothelial Cells

Autor: Wouter J. C. Feitz, Nicole C. A. J. van de Kar, Ian Cheong, Thea J. A. M. van der Velden, Carolina G. Ortiz-Sandoval, Dorothea Orth-Höller, Lambert P. J. W. van den Heuvel, Christoph Licht

Publikováno v: Toxins, Vol 12, Iss 8, p 483 (2020)

Hemolytic uremic syndrome (HUS) is a rare disease primarily characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Endothelial damage is the hallmark of the pathogenesis of HUS with an infection with the Shiga toxin (Stx) produ

Externí odkaz: https://doaj.org/article/5eb0a7aba7d740c988b3f38747293aad

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Prediction of Moxifloxacin Concentrations in Tuberculosis Patient Populations by Physiologically Based Pharmacokinetic Modeling

Publikováno v: Journal of Clinical Pharmacology and Journal of New Drugs, 62, 3, pp. 385-396
Journal of Clinical Pharmacology and Journal of New Drugs, 62, 385-396

Contains fulltext : 248642.pdf (Publisher’s version ) (Open Access) Moxifloxacin has an important role in the treatment of tuberculosis (TB). Unfortunately, coadministration with the cornerstone TB drug rifampicin results in suboptimal plasma expos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e627cee41f24ef6bdaceab6a4f0d8b
https://doi.org/10.1002/jcph.1972

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