Zobrazeno 1 - 10
of 188
pro vyhledávání: '"W. van Osdol"'
Publikováno v:
Journal of Membrane Science. 293:174-182
The stratum corneum is the outermost layer of the skin, which acts as a barrier membrane against the penetration of molecules into and out of the body. It has a biphasic structure consisting of keratinized cells – the corneocytes – that are embed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94c284a11192f2d8cd9df2fad5e73cd2
https://doi.org/10.1016/j.memsci.2007.02.018
https://doi.org/10.1016/j.memsci.2007.02.018
Autor:
J. Scicinski, Y. Xu, Jing Chen, Gary Eichenbaum, Ludo Edmond Josephine Kennis, Liang C. Dong, Crystal Pollock-Dove, Claire Mackie, Anton Megens, Wei-Guo Dai, D. Ashton, J. Evans, W. van Osdol, H. Borghys, Joseph Vu Nguyen, Shaoling Sunnyvale Li
Publikováno v:
Journal of Pharmaceutical Sciences. 95:883-895
In this paper, we present a preclinical approach for evaluating the feasibility of applying controlled-release (CR) oral drug delivery to increase the duration of exposure and lower the C max of compounds in a lead series of short half-life atypical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b31c146198a7f93a0593e54b8f74bf
https://doi.org/10.1002/jps.20550
https://doi.org/10.1002/jps.20550
Publikováno v:
Biomaterials. 27:785-795
An in vitro mechanics approach to quantify the intercellular delamination energy and mechanical behavior of isolated human stratum corneum (SC) in a direction perpendicular to the skin surface is presented. The effects of temperature, hydration, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2382c64853244429bbc56d1291f05e89
https://doi.org/10.1016/j.biomaterials.2005.06.019
https://doi.org/10.1016/j.biomaterials.2005.06.019
Publikováno v:
Annals of Biomedical Engineering. 33:1422-1438
The finite element method is employed to simulate two-dimensional (axisymmetric) drug diffusion from a finite drug reservoir into the skin. The numerical formulation is based on a general mathematical model for multicomponent nonlinear diffusion that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde2b57cd4411482bc1e044615ff8ced
https://doi.org/10.1007/s10439-005-5788-6
https://doi.org/10.1007/s10439-005-5788-6
Finite element model of antibody penetration in a prevascular tumor nodule embedded in normal tissue
Publikováno v:
Journal of Controlled Release. 74:193-202
We have developed a pharmacokinetic model for monoclonal antibodies (mAb) to aid in investigating protocols for targeting small primary tumors or sites of metastatic disease. The model describes the uptake of systemically-administered antibody by a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee48f4fc1cd477ba804a4c0913f138ff
https://doi.org/10.1016/s0168-3659(01)00317-0
https://doi.org/10.1016/s0168-3659(01)00317-0
Autor:
John N. Weinstein, N. L. Anderson, K. Raghavan, Jonathan D. Licht, Dominic A. Scudiero, Timothy G. Myers, Daniel W. Zaharevitz, W. W. Van Osdol, Vellarkad N. Viswanadhan, Kenneth D. Paull, John K. Buolamwini, Larry Rubinstein, Bruce A. Chabner, Antonis D. Koutsoukos, Anne Monks, Kurt W. Kohn, Michael R. Grever
Publikováno v:
STEM CELLS. 12:13-22
The National Cancer Institute's drug discovery program screens more than 20,000 chemical compounds and natural products a year for activity against a panel of 60 tumor cell lines in vitro. The result is an information-rich database of patterns that f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb4686ad1f33439761256d3ca97d78f
https://doi.org/10.1002/stem.5530120106
https://doi.org/10.1002/stem.5530120106
Autor:
ŽALOUDKOVÁ, BLANKA1, KOUDELKA, PETR2, FRÝDLOVÁ, PETRA3, DROZDENKO, MYKHAILO4, ŠLEICHRT, JAN2, KYTÝŘ, DANIEL2 kytyr@itam.cas.cz
Publikováno v:
Acta Polytechnica CTU Proceedings. 2024, Vol. 48, p61-65. 5p.
Publikováno v:
Long Acting Injections and Implants ISBN: 9781461405535
In situ forming systems transform into semi-solids (or viscous masses) upon injection and provide sustained release of pharmacological agents, including small molecule drugs, peptides and proteins. These formulations can be utilized for systemic or s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e4e5b49e51c82207863cca838ef4ee4
https://doi.org/10.1007/978-1-4614-0554-2_9
https://doi.org/10.1007/978-1-4614-0554-2_9
Publikováno v:
Rim, Jee E.; Pinsky, Peter M.; & Osdol, William W.(2009). Multiscale Modeling Framework of Transdermal Drug Delivery. Annals of Biomedical Engineering: The Journal of the Biomedical Engineering Society, 37(6), pp 1217-1229. doi: 10.1007/s10439-009-9678-1. Retrieved from: http://www.escholarship.org/uc/item/58p2g44n
This study addresses the modeling of transdermal diffusion of drugs to better understand the permeation of molecules through the skin, especially the stratum corneum, which forms the main permeation barrier to percutaneous permeation. In order to ens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1674e5d6cab82a5503989d1587e532e6
http://www.escholarship.org/uc/item/58p2g44n
http://www.escholarship.org/uc/item/58p2g44n
Publikováno v:
Biophysical Journal. 60(5):1002-1007
The relaxation kinetics of the gel-liquid crystalline transition of phosphatidylcholine (DC14PC, DC16PC, and DC18PC) multilamellar vesicles have been examined using volume-perturbation calorimetry. The time-dependent temperature and pressure changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6884c338a9e677f11deb353144d42061