Zobrazeno 1 - 10
of 103
pro vyhledávání: '"W. Winn Chatham"'
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss Suppl 2 (2024)
Externí odkaz:
https://doaj.org/article/bbbf90b091224932932b330c613db1be
Lupus nephritis correlates with B cell interferon-β, anti-Smith, and anti-DNA: a retrospective study
Autor:
Fatima Alduraibi, Huma Fatima, Jennie A. Hamilton, W. Winn. Chatham, Hui-Chen Hsu, John D. Mountz
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-11 (2022)
Abstract Background In systemic lupus erythematosus (SLE), detection of interferon-β (IFNβ) in B cells was found to be most prominent in patients with high anti-Smith (Sm) and renal disease, but a mechanistic connection was not clear. The objective
Externí odkaz:
https://doaj.org/article/57428646da2e43a58aca30a8fe32a805
Publikováno v:
Annual Review of Medicine. 74:321-337
Cytokine storm syndrome (CSS), which is frequently fatal, has garnered increased attention with the ongoing coronavirus pandemic. A variety of hyperinflammatory conditions associated with multiorgan system failure can be lumped under the CSS umbrella
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c77ae9ecc5570c83c97da8f4785948a
https://doi.org/10.1146/annurev-med-042921-112837
https://doi.org/10.1146/annurev-med-042921-112837
Publikováno v:
The Journal of Immunology. 209:1513-1522
Activated naive (aNAV) B cells have been shown to be the precursor of the CD11c+T-bet+ IgD−CD27− double-negative (DN)2 or atypical memory (aMEM) B cells in systemic lupus erythematosus (SLE). To determine factors that maintain resting naive (rNAV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0831c6c81ccced7d4512520ce97000a3
https://doi.org/10.4049/jimmunol.2200409
https://doi.org/10.4049/jimmunol.2200409
Autor:
Jasvinder A Singh, Liana Fraenkel, Candace Green, Graciela S Alarcón, Jennifer L Barton, Kenneth G Saag, Leslie M Hanrahan, Sandra C Raymond, Robert P Kimberly, Amye L Leong, Elyse Reyes, Richard L Street, Maria E Suarez-Almazor, Guy S Eakin, Laura Marrow, Charity J Morgan, Brennda Caro, Jeffrey A Sloan, Bochra Jandali, Salvador R Garcia, Jennifer Grossman, Kevin L Winthrop, Laura Trupin, Maria Dall'Era, Alexa Meara, Tara Rizvi, W Winn Chatham, Jinoos Yazdany
Publikováno v:
PLoS Medicine, Vol 16, Iss 5, p e1002800 (2019)
BackgroundTreatment decision-making regarding immunosuppressive therapy is challenging for individuals with lupus. We assessed the effectiveness of a decision aid for immunosuppressive therapy in lupus nephritis.Methods and findingsIn a United States
Externí odkaz:
https://doaj.org/article/80c34e59863941a9b74c645f9b11ae86
Autor:
Esther Zumaquero, Sara L Stone, Christopher D Scharer, Scott A Jenks, Anoma Nellore, Betty Mousseau, Antonio Rosal-Vela, Davide Botta, John E Bradley, Wojciech Wojciechowski, Travis Ptacek, Maria I Danila, Jeffrey C Edberg, S Louis Bridges Jr, Robert P Kimberly, W Winn Chatham, Trenton R Schoeb, Alexander F Rosenberg, Jeremy M Boss, Ignacio Sanz, Frances E Lund
Publikováno v:
eLife, Vol 8 (2019)
Although B cells expressing the IFNγR or the IFNγ-inducible transcription factor T-bet promote autoimmunity in Systemic Lupus Erythematosus (SLE)-prone mouse models, the role for IFNγ signaling in human antibody responses is unknown. We show that
Externí odkaz:
https://doaj.org/article/fc145a6e8204428a8ea15655113e477f
Autor:
W. Winn Chatham, Erik Schwetje, Richard Furie, Amit Saxena, Philip Z Brohawn, Gabriel Abreu, Raj Tummala
Publikováno v:
Arthritis Rheumatol
Arthritis & Rheumatology (Hoboken, N.j.)
Arthritis & Rheumatology (Hoboken, N.j.)
Objective To investigate long-term safety and tolerability of anifrolumab, a human monoclonal antibody to the type I interferon (IFN) receptor subunit 1, in patients with moderate-to-severe systemic lupus erythematosus (SLE). Methods This 3-year, mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7951c118f9816a45aca07681746e2bf3
https://doi.org/10.1002/art.41598
https://doi.org/10.1002/art.41598
Autor:
Wendy Gao, Margie Byron, Betty Diamond, Diane L. Kamen, Maria Dall'Era, Cynthia Aranow, Anca D. Askanase, Amit Saxena, Susan A. Boackle, Kristin Ryker, Linna Ding, Patti Tosta, Sai Kanaparthi, Kristina M. Harris, Samir V. Parikh, Kyriakos A. Kirou, Maureen McMahon, S. Sam Lim, William F. Pendergraft, David Wofsy, Dawn E. Smilek, W. Winn Chatham, Susan Malkiel, Amber S. Podoll, Bradley Marder, Y Atisha-Fregoso, William T. Barry, David R. Karp
Publikováno v:
Arthritis & Rheumatology (Hoboken, N.j.)
Arthritis Rheumatol
Arthritis Rheumatol
Objective To assess the safety, mechanism of action, and preliminary efficacy of rituximab followed by belimumab in the treatment of refractory lupus nephritis (LN). Methods In a multicenter, randomized, open-label clinical trial, 43 patients with re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c4b88b5e4839396236501e0fd9ad4a
http://europepmc.org/articles/PMC7839443
http://europepmc.org/articles/PMC7839443
Autor:
W. Winn Chatham, Randy Q. Cron
Publikováno v:
The Journal of Rheumatology. 47:639-642
The novel coronavirus (SARS-CoV-2) pandemic has spread rapidly throughout the planet. It is believed to have originated in the Wuhan province of China, but this highly contagious respiratory virus has spread to over 140 countries on 6 continents as o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25f8ea2d8e1814312870b4c8758ddd9
https://doi.org/10.3899/jrheum.200334
https://doi.org/10.3899/jrheum.200334
Publikováno v:
Clinical Immunology. 247:109239
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ebfac7275c2978dc8b9fffda25aff93
https://doi.org/10.1016/j.clim.2023.109239
https://doi.org/10.1016/j.clim.2023.109239