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Akademický článek

Chromatin sequesters pioneer transcription factor Sox2 from exerting force on DNA

Autor: Tuan Nguyen, Sai Li, Jeremy T-H Chang, John W. Watters, Htet Ng, Adewola Osunsade, Yael David, Shixin Liu

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)

Here the authors used single-molecule imaging and manipulation to study the mechanical effects of transcription factor Sox2 co-condensation with DNA and chromatin. They found that Sox2 condensates exert a high level of mechanical stress on DNA, but t

Externí odkaz: https://doaj.org/article/a5fc41cecb574669a410977790cd6293

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Metabolic response of microglia to amyloid deposition during Alzheimer’s disease progression in a mouse model

Autor: Kaitlyn M. Marino, Jayne M. Squirrell, Jenu V. Chacko, Jyoti W. Watters, Kevin W. Eliceiri, Tyler K. Ulland

SummaryAlzheimer’s disease (AD) drives metabolic changes in the central nervous system (CNS). In AD microglia are activated and proliferate in response to amyloid β plaques. To further characterize the metabolic changes in microglia associated wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aea9e28d906fca440ea40b15f34fec18
https://doi.org/10.1101/2023.05.12.540407

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Data from De novo Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model

Autor: Karuppiah Kannan, Nancy Kohl, Murray O. Robinson, M. Isabel Chiu, Steve Clark, Tim Demuth, John F. Reilly, Christopher Winter, Chris Ware, Joerg Heyer, Jie Lin, Wenping Sun, Lingxin Kong, Carol Meeske, Sireesha Yalavarthi, Ruojie Wang, Pradip K. Majumder, Chun Cheng, James W. Watters

Notch pathway signaling plays a fundamental role in normal biological processes and is frequently deregulated in many cancers. Although several hypotheses regarding cancer subpopulations most likely to respond to therapies targeting the Notch pathway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bde16d7f424b454e060ac021a814bec6
https://doi.org/10.1158/0008-5472.c.6500225.v1

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Head-on and co-directional RNA polymerase collisions orchestrate bidirectional transcription termination

Autor: Ling Wang, John W. Watters, Xiangwu Ju, Shixin Liu

SUMMARYGenomic DNA is a crowded track where translocating motor proteins frequently collide. It remains unclear whether these collisions, generally thought to occur inadvertently, carry any physiological function. In this work, we developed a single-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::940db491a97fd51afba455d2d8249006
https://doi.org/10.1101/2022.10.23.513370

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Single-stranded nucleic acid binding and coacervation by linker histone H1

Autor: Rachel Leicher, Adewola Osunsade, Gabriella N. L. Chua, Sarah C. Faulkner, Andrew P. Latham, John W. Watters, Tuan Nguyen, Emily C. Beckwitt, Sophia Christodoulou-Rubalcava, Paul G. Young, Bin Zhang, Yael David, Shixin Liu

Publikováno v: Nat Struct Mol Biol

The H1 linker histone family is the most abundant group of eukaryotic chromatin-binding proteins. However, their contribution to chromosome structure and function remains incompletely understood. Here we use single-molecule fluorescence and force mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13d9511e093efc8eba43aa873cd6fbc
https://europepmc.org/articles/PMC9117509/

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Design and Evaluation of Artificial Hybrid Photoredox Biocatalysts

Autor: David A. Nicewicz, Evan W. Reynolds, Cole L. Cruz, Timothy D. Schwochert, Eric M. Brustad, John W. Watters

Publikováno v: ChemBioChem. 21:3146-3150

A pair of 9-mesityl-10-phenyl acridinium (Mes-Acr+ ) photoredox catalysts were synthesized with an iodoacetamide handle for cysteine bioconjugation. Covalently tethering of the synthetic Mes-Acr+ cofactors with a small panel of thermostable protein s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6359ea27fdb545715a202d495542708d
https://doi.org/10.1002/cbic.202000362

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Chromatin sequesters pioneer transcription factor Sox2 from exerting force on DNA

Autor: Tuan Nguyen, Sai Li, Jeremy T-H Chang, John W. Watters, Htet Ng, Adewola Osunsade, Yael David, Shixin Liu

Publikováno v: Nature communications. 13(1)

Formation of biomolecular condensates constitutes an emerging mechanism for transcriptional regulation. Recent studies suggest that the co-condensation between transcription factors (TFs) and DNA can generate mechanical forces driving genome rearrang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19b56072e744a79346f5cfe5c7ab082
https://pubmed.ncbi.nlm.nih.gov/35810158

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Single-stranded nucleic acid sensing and coacervation by linker histone H1

Autor: Rachel Leicher, Adewola Osunsade, Gabriella N.L. Chua, Sarah C. Faulkner, Andrew P. Latham, John W. Watters, Tuan A. Nguyen, Emily C. Beckwitt, Sophia Christodoulou-Rubalcava, Paul G. Young, Bin Zhang, Yael David, Shixin Liu

Publikováno v: Biophysical Journal. 121:357a-358a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d755444ac58fb09e41371464a30fb3c
https://doi.org/10.1016/j.bpj.2021.11.974

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