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Autor: W W, Weber

Publikováno v: Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology. 4(4)

Population frequencies of many polymorphic genes of pharmacogenetic interest depend on race or ethnic specificity. Association of these genes with person-to-person differences in drug effectiveness (hypersensitivity or resistance) and drug toxicity m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::181a2ce6fbf159a2d3b0fdb56c0113fd
https://pubmed.ncbi.nlm.nih.gov/10671640

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Tissue- and gender-specific expression of N-acetyltransferase 2 (Nat2*) during development of the outbred mouse strain CD-1

Autor: L, Estrada, K C, Kanelakis, G N, Levy, W W, Weber

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 28(2)

The human N-acetyltransferase (Nat2) genetic polymorphisms have been modeled in mouse strains. We determined the phenotype and genotype of the N-acetyltransferase 2 (Nat2*) gene among outbred CD-1 mice and found a mixed population of heterozygous and

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https://pubmed.ncbi.nlm.nih.gov/10640510

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Substrate selectivity of mouse N-acetyltransferases 1, 2, and 3 expressed in COS-1 cells

Autor: L, Estrada-Rodgers, G N, Levy, W W, Weber

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 26(5)

Two human acetyl-CoA:arylamine N-acetyltransferases (NAT1 and NAT2) have been identified. Therapeutic and carcinogenic agents that are substrates for these isoenzymes (including isoniazid, sulfamethazine, p-aminobenzoic acid, 5-aminosalicyclic acid,

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https://pubmed.ncbi.nlm.nih.gov/9571233

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Ahr locus phenotype in congenic mice influences hepatic and pulmonary DNA adduct levels of 2-amino-3-methylimidazo[4,5-f]quinoline in the absence of cytochrome P450 induction

Autor: P V, Nerurkar, H A, Schut, L M, Anderson, C W, Riggs, L W, Fornwald, C D, Davis, E G, Snyderwine, S S, Thorgeirsson, W W, Weber, J M, Rice, G N, Levy

Publikováno v: Molecular pharmacology. 49(5)

The potent food mutagen/carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) undergoes metabolic N-hydroxylation by cytochromes P450, including cytochrome P450 1A2, followed by generation of an unstable ester catalyzed by acetyltransferases; promu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::10d846b8ce6e0235c266dc0bdc41ef04
https://pubmed.ncbi.nlm.nih.gov/8622637

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Kinetics of acetyl coenzyme A:arylamine N-acetyltransferase from rapid and slow acetylator frog tissues

Autor: C C, Ho, T H, Lin, Y S, Lai, J G, Chung, G N, Levy, W W, Weber

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 24(2)

N-acetyltransferase (NAT) activity was determined in 100 frog (Rana tigrina) livers using 2-aminofluorene and p-aminobenzoic acid as substrates. Overall, the liver NAT activity of the 50 females was higher than the liver NAT activity of the 50 males.

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https://pubmed.ncbi.nlm.nih.gov/8742223

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Slow acetylation in mice is caused by a labile and catalytically impaired mutant N-acetyltransferase (NAT2 9)

Autor: J H, De Leon, K J, Martell, K P, Vatsis, W W, Weber

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 23(12)

Three N-acetyltransferase genes (NAT*) were detected in inbred parental and congenic mice. Direct sequencing of NAT2* and liver cytosolic N-acetylation activity determinations with NAT2-specific (p-aminobenzoic acid) and NAT2-selective (2-aminofluore

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https://pubmed.ncbi.nlm.nih.gov/8689943

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DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in colon, bladder, and kidney of congenic mice differing in Ah responsiveness and N-acetyltransferase genotype

Autor: P V, Nerurkar, H A, Schut, L M, Anderson, C W, Riggs, E G, Snyderwine, S S, Thorgeirsson, W W, Weber, J M, Rice, G N, Levy

Publikováno v: Cancer research. 55(14)

Heterocyclic amines, suspected as cancer initiators, require metabolic activation to exert genotoxicity. The food carcinogen 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) undergoes activation via N-hydroxylation by cytochrome P450 1A2, followed by O-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9ac0fb371772109db3f270895ca454f9
https://pubmed.ncbi.nlm.nih.gov/7606725

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Human N-Acetyltransferases

Autor: K. P. Vatsis, W. W. Weber

Publikováno v: Handbook of Experimental Pharmacology ISBN: 9783642784316

Human variability in drug acetylation was discovered nearly four decades ago during the initial clinical trials of isoniazid as an antituberculosis drug (reviewed in Weber 1987). Isoniazid was a remarkably effective therapeutic agent, but, despite it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5d91100def187e05e4ff340b510b9c6
https://doi.org/10.1007/978-3-642-78429-3_4

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