Zobrazeno 1 - 10
of 19
pro vyhledávání: '"W. W. Day"'
Publikováno v:
Pharmaceutical Research. 15:93-97
Purpose. To apply cocktail approaches for protein binding (PB) and pharmacokinetics (PK) within a discovery program as a means of providing timely systemic exposure (AUC and Cmax) data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::684df88d8f06529a37317a996dd92992
https://doi.org/10.1023/a:1011909022226
https://doi.org/10.1023/a:1011909022226
Autor:
L H, Belkoff, A, McCullough, I, Goldstein, L, Jones, C H, Bowden, K, DiDonato, B, Trask, W W, Day
Publikováno v:
International journal of clinical practice. 67(4)
Determine the long-term efficacy, safety and tolerability of avanafil, a highly specific, rapidly absorbed phosphodiesterase type 5 inhibitor in male patients with mild to severe erectile dysfunction (ED), with or without diabetes.This was a 52-week,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33136cc42cd275000a5ec6094da87077
https://pubmed.ncbi.nlm.nih.gov/23521325
https://pubmed.ncbi.nlm.nih.gov/23521325
Publikováno v:
Pharmaceutical research. 15(1)
To apply cocktail approaches for protein binding (PB) and pharmacokinetics (PK) within a discovery program as a means of providing timely systemic exposure (AUC and Cmax) data.For PB data, a procedure of cocktail ultrafiltration, mixed matrix sample
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::24cf37a729a5239075ae482a6e63f5e2
https://pubmed.ncbi.nlm.nih.gov/9487553
https://pubmed.ncbi.nlm.nih.gov/9487553
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 21(3)
Renal cytochrome P-450 levels, metabolism of acetaminophen (APAP) and aminopyrine, and activities of several phase II-associated enzymes [UDPGT, beta-glucuronidase, and glutathione-S-transferase (GST)] were determined in sedentary and exercised young
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::98f2488948c1549e22e403f09d42926f
https://pubmed.ncbi.nlm.nih.gov/8100504
https://pubmed.ncbi.nlm.nih.gov/8100504
Publikováno v:
Atherosclerosis. 134:122
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3d9c9c5b8325280742ad1f2122acc76
https://doi.org/10.1016/s0021-9150(97)88665-0
https://doi.org/10.1016/s0021-9150(97)88665-0
Publikováno v:
Research communications in chemical pathology and pharmacology. 62(2)
The interaction of methacrylonitrile (MeAN) with glutathione (GSH) was evaluated in aqueous solution and its in vivo potential to deplete GSH in male Sprague Dawley rats at the 0.5 LD50 dose of 100 mg MeAN/Kg body weight was investigated. Addition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e97784c273e9a172d609daa0ff9d47ff
https://pubmed.ncbi.nlm.nih.gov/3251336
https://pubmed.ncbi.nlm.nih.gov/3251336
Autor:
W. W. Day
Publikováno v:
BMJ. 2:1265-1265
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ab912c20439f7ff3f573f1fcf4072a6
https://doi.org/10.1136/bmj.2.1251.1265-a
https://doi.org/10.1136/bmj.2.1251.1265-a
Akademický článek
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Autor:
Day W; Silsoe Research Institute, Wrest Park, Silsoe, Bedford MK45 4HS, UK. bill.day@silsoeresearch.org.uk, Audsley E, Frost AR
Publikováno v:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences [Philos Trans R Soc Lond B Biol Sci] 2008 Feb 12; Vol. 363 (1491), pp. 527-41.