Zobrazeno 1 - 10 of 94 pro vyhledávání: '"W. Van Duijn"'
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Akademický článek
Characterization of Heterogeneous Prostate Tumors in Targeted Pten Knockout Mice.
Autor: Hanneke Korsten, Angelique C J Ziel-van der Made, Wytske M van Weerden, Theo van der Kwast, Jan Trapman, Petra W Van Duijn
Publikováno v: PLoS ONE, Vol 11, Iss 1, p e0147500 (2016)
Previously, we generated a preclinical mouse prostate tumor model based on PSA-Cre driven inactivation of Pten. In this model homogeneous hyperplastic prostates (4-5m) developed at older age (>10m) into tumors. Here, we describe the molecular and his
Externí odkaz: https://doaj.org/article/04529b4168a7415d832f1d571e13be43
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3
Tumor heterogeneity, aggressiveness, and immune cell composition in a novel syngeneic PSA-targeted Pten knockout mouse prostate cancer (MuCaP) model
Autor: Petra W van Duijn, Cor A. Berrevoets, Angelique C.J. Ziel-van der Made, Ashraf Aghai, Wytske M. van Weerden, Guido Jenster, Rute B. Marques, Jan Trapman, Reno Debets, Hanneke J. A. A. van Zoggel
Publikováno v: Prostate, 78(13), 1013-1023. Wiley-Liss Inc.
Background Prostate cancer is recognized as a heterogeneous disease demanding appropriate preclinical models that reflect tumor complexity. Previously, we established the PSA-Cre;PtenLoxP/LoxP genetic engineered mouse model (GEMM) for prostate cancer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1aa427d28d0ad67f423dd911ea02dd6
https://doi.org/10.1002/pros.23659
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4
Spatial aspects of oncogenic signalling determine the response to combination therapy in slice explants from Kras-driven lung tumours
Autor: Wolfgang Sommergruber, Riku Turkki, Mikko I. Mäyränpää, Olli Kallioniemi, Katja Närhi, Jenni Lahtela, Virva Uotinen, Emmy W. Verschuren, Annabrita Hemmes, Taija af Hällström, Simon Anders, Antti Rannikko, Jari Räsänen, Nina Linder, Ashwini S. Nagaraj, Petra W van Duijn, Kaisa Salmenkivi, Elina Parri, Jan Trapman, Johan Lundin
Publikováno v: Journal of Pathology, 245(1), 101-113. John Wiley & Sons Ltd.
The Journal of Pathology
A key question in precision medicine is how functional heterogeneity in solid tumours informs therapeutic sensitivity. We demonstrate that spatial characteristics of oncogenic signalling and therapy response can be modelled in precision-cut slices fr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f766be33f2ab7f68d5121725cb9d845
http://hdl.handle.net/10138/333759
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MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients
Autor: Cornelis F. M. Sier, W. van Duijn, Lukas J. A. C. Hawinkels, James C. H. Hardwick, Alexandra M. J. Langers, F.J.G.M. Kubben, H. W. Verspaget, Daan W. Hommes, J. J. van der Reijden
Publikováno v: British Journal of Cancer, 106(9), 1495-1498
British Journal of Cancer
Background: Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients. Methods: We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18840b661106cc6da0f645072890aa14
https://doi.org/10.1038/bjc.2012.80
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MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not
Autor: Alexandra M. J. Langers, Daan W. Hommes, Lukas J. A. C. Hawinkels, Cornelis F. M. Sier, F.J.G.M. Kubben, J. J. van der Reijden, Hein W. Verspaget, W. van Duijn, Cornelis B.H.W. Lamers
Publikováno v: British Journal of Cancer
The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2(-1306T) and high MMP-2 levels were significantly
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea9a75208a901f63ff88cd61b0693f1
http://europepmc.org/articles/PMC2410128
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Increased mucosal matrix metalloproteinase-1, -2, -3 and -9 activity in patients with inflammatory bowel disease and the relation with Crohn's disease phenotype
Autor: Daan W. Hommes, W. van Duijn, Hein W. Verspaget, R. A. van Hogezand, A.M. van der Zon, Marij A C Mieremet-Ooms, Cornelis F. M. Sier, Cornelis B.H.W. Lamers, M.J.W. Meijer
Publikováno v: Digestive and Liver Disease. 39:733-739
Background and objective Matrix metalloproteinases are associated with matrix turnover in both physiological and pathological conditions. We postulate an association between aberrant matrix metalloproteinases proteolytic activity and the intestinal t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f614aad8e822c640cf899ac09a4a20
https://doi.org/10.1016/j.dld.2007.05.010
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Tissue level, activation and cellular localisation of TGF-β1 and association with survival in gastric cancer patients
Autor: W. van Duijn, F.J.G.M. Kubben, Kim Zuidwijk, Lukas J. A. C. Hawinkels, Hein W. Verspaget, Jan H. Verheijen, Cornelis B.H.W. Lamers, J. M. Van Der Zon, Daan W. Hommes, Cornelis F. M. Sier
Publikováno v: British Journal of Cancer, 3, 97, 398-404
British Journal of Cancer
Transforming growth factor-beta1 (TGF-beta1), a tumour suppressing as well as tumour-promoting cytokine, is stored as an extracellular matrix-bound latent complex. We examined TGF-beta1 activation and localisation of TGF-beta1 activity in gastric can
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b9ba36400f5849d45bd364f6893f35
https://doi.org/10.1038/sj.bjc.6603877
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9
PI3K/Akt signaling regulates p27kip1 expression via Skp2 in PC3 and DU145 prostate cancer cells, but is not a major factor in p27kip1 regulation in LNCaP and PC346 cells
Autor: J. Trapman, Petra W. van Duijn
Publikováno v: The Prostate. 66:749-760
BACKGROUND We compared the involvement of PI3K/PTEN/Akt signaling in the regulation of the cell-cycle regulator p27kip1 and investigated the mechanism of PI3K/PTEN/Akt modulation of p27kip1 in the prostate cancer cell lines LNCaP, PC346, PC3, and DU1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c1feed024647303b1b568d8443f78d
https://doi.org/10.1002/pros.20398
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Expression of matrix metalloproteinases-2 and -9 in intestinal tissue of patients with inflammatory bowel diseases
Autor: Hein W. Verspaget, R. A. van Hogezand, Cornelis B.H.W. Lamers, L. Kruidenier, M. van den Berg, W. van Duijn, Cornelis F. M. Sier, M.J.W. Meijer, F.J.G.M. Kubben, Qiang Gao
Publikováno v: Digestive and Liver Disease. 37:584-592
Background/aims. Matrix metalloproteinases are major contributors in the breakdown and reconstitution of basement membranes and extracellular matrix in pathophysiological processes. We assessed the expression of matrix metalloproteinases-2 and -9 in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c89986be6638df5250efdc3d04f7439
https://doi.org/10.1016/j.dld.2005.02.011
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