Zobrazeno 1 - 10 of 112 pro vyhledávání: '"W. Towers"'
1
Faster raster matrix-assisted laser desorption/ionization mass spectrometry imaging of lipids at high lateral resolution
Autor: Ron M. A. Heeren, Frédéric Dewez, Emmanuelle Claude, Beatriz Rocha, Florian P.Y. Barré, Tiffany Porta Siegel, Berta Cillero-Pastor, Paul Murray, Mark W. Towers
Publikováno v: International Journal of Mass Spectrometry, 437, 38-48. Elsevier
International Journal of Mass Spectrometry
The clinical use of mass spectrometry imaging (MSI) is rapidly growing, and applications are expanding. Crucially, the analysis of clinical cohorts requires a combination of higher analytical throughput and higher lateral resolution. Here, we demonst
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02527aa12f51b61478843c52f1f85412
https://doi.org/10.1016/j.ijms.2018.09.015
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2
Optimised Desorption Electrospray Ionisation Mass Spectrometry Imaging (DESI-MSI) for the Analysis of Proteins/Peptides Directly from Tissue Sections on a Travelling Wave Ion Mobility Q-ToF
Autor: Tamás Karancsi, Steven Derek Pringle, Emmanuelle Claude, Emrys A. Jones, Mark W. Towers
Publikováno v: Journal of the American Society for Mass Spectrometry
Desorption electrospray ionisation mass spectrometry imaging (DESI-MSI) is typically known for the ionisation of small molecules such as lipids and metabolites, in singly charged form. Here we present a method that allows the direct detection of prot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa75e61a886e63f7db21b2a73077a63
https://doi.org/10.1007/s13361-018-2049-0
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3
BASIS: High-performance bioinformatics platform for processing of large-scale mass spectrometry imaging data in chemically augmented histology
Autor: Emmanuelle Claude, James I. Langridge, Reza Mirnezami, Dieter Galea, Jonathan P. Sleeman, Zoltan Takats, Ivan Laponogov, Robert Tonge, Kirill Veselkov, Mark W. Towers, Jeremy K. Nicholson, Anna Mroz, Johannes P. C. Vissers
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific reports, 8 (1), Art.Nr.: 4053
Scientific Reports
Mass Spectrometry Imaging (MSI) holds significant promise in augmenting digital histopathologic analysis by generating highly robust big data about the metabolic, lipidomic and proteomic molecular content of the samples. In the process, a vast quanti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100446417b631c58ba357b4bad326c98
http://link.springer.com/article/10.1038/s41598-018-22499-z
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4
Lipidomics for translational skin research: A primer for the uninitiated
Autor: Emrys A. Jones, Michael Morris, Alexandra C. Kendall, Anna Nicolaou, Christopher E.M. Griffiths, Marta M Koszyczarek, Philippa J. Hart, Mark W. Towers
Publikováno v: Kendall, A C, Koszyczarek, M M, Jones, E A, Hart, P J, Towers, M, Griffiths, C E M, Morris, M & Nicolaou, A 2018, ' Lipidomics for translational skin research: a primer for the uninitiated ', Experimental Dermatology, vol. 27, no. 7, pp. 721-728 . https://doi.org/10.1111/exd.13558
Healthy skin depends on a unique lipid profile to form a barrier that confers protection and prevents excessive water loss, aids cell‐cell communication, and regulates cutaneous homeostasis and inflammation. Alterations in the cutaneous lipid profi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55300e4242607b967373c2135bc2f691
https://pubmed.ncbi.nlm.nih.gov/29654617
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5
In vivo isotopically labeled atherosclerotic aorta plaques in ApoE KO mice and molecular profiling by matrix-assisted laser desorption/ionization mass spectrometric imaging
Autor: Sheng-Ping Wang, Henry Shion, Douglas G. Johns, Vinit Shah, Nana Kofi Karikari, Michele A. Cleary, Karen O. Akinsanya, Jose Castro-Perez, John P. Shockcor, Vivienne Mendoza, Thomas P. Roddy, Mark W. Towers, David G. McLaren, Nathan G. Hatcher, Stephen F. Previs, Alan Millar
Publikováno v: Rapid Communications in Mass Spectrometry. 28:2471-2479
RATIONALE The ability to quantify rates of formation, regression and/or remodeling of atherosclerotic plaque should facilitate a better understanding of the pathogenesis and management of cardiovascular disease. In the current study, we coupled a sta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3a7028b23d0864955ca640d15f27316
https://doi.org/10.1002/rcm.7039
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7
Enhanced capabilities for imaging gangliosides in murine brain with matrix-assisted laser desorption/ionization and desorption electrospray ionization mass spectrometry coupled to ion mobility separation
Autor: Karolina Škrášková, Ron M. A. Heeren, Mark W. Towers, Shane R. Ellis, Emrys A. Jones, Emmanuelle Claude
Publikováno v: Methods, 104, 69-78. Elsevier Science
The increased interest in lipidomics calls for improved yet simplified methods of lipid analysis. Over the past two decades, mass spectrometry imaging (MSI) has been established as a powerful technique for the analysis of molecular distribution of a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a4cd8a04352bebc0a5123fa33bfe85
https://cris.maastrichtuniversity.nl/en/publications/ecf08a4b-0c6d-4c88-8612-dce93a2d5c43
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8
Ionic Liquids and Other Liquid Matrices for Sensitive MALDI MS Analysis
Autor: Mark W. Towers, Rainer Cramer
Publikováno v: Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry ISBN: 9783319048185
Although liquid matrix-assisted laser desorption/ionization (MALDI) has been used in mass spectrometry (MS) since the early introduction of MALDI, its substantial lack of sensitivity compared to solid (crystalline) MALDI was for a long time a major h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63b0c69c1566904732db82669dca7a78
https://doi.org/10.1007/978-3-319-04819-2_3
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9
Qualification of FTIR spectroscopic method for protein secondary structural analysis
Autor: Xichdao Nguyen, Linda O. Narhi, John P. Gabrielson, Yijia Jiang, Salman Muzammil, Cynthia Li, Edward W. Towers
Publikováno v: Journal of Pharmaceutical Sciences. 100:4631-4641
Fourier transform infrared (FTIR) spectroscopy is widely used to study protein secondary structure both in solution and in the solid state. The FTIR spectroscopic method has also been employed as a characterization method by the biopharmaceutical ind
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3bfefa548c94ff12d245685d565bd9
https://doi.org/10.1002/jps.22686
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10
Applications of circular dichroism (CD) for structural analysis of proteins: qualification of near‐ and far‐UV CD for protein higher order structural analysis
Autor: Yijia Jiang, Edward W. Towers, Letha Chemmalil, John P. Gabrielson, Salman Muzammil, Cynthia Li, Xichdao Nguyen, Linda O. Narhi
Publikováno v: Journal of Pharmaceutical Sciences. 100:4642-4654
Circular dichroism (CD) spectroscopy is routinely used in the biopharmaceutical industry to study the effects of manufacturing, formulation, and storage conditions on protein conformation and stability, and these results are often included in regulat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2692fe6dcaa99380bb84600f5565d75d
https://doi.org/10.1002/jps.22695
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