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Faster raster matrix-assisted laser desorption/ionization mass spectrometry imaging of lipids at high lateral resolution

Autor: Ron M. A. Heeren, Frédéric Dewez, Emmanuelle Claude, Beatriz Rocha, Florian P.Y. Barré, Tiffany Porta Siegel, Berta Cillero-Pastor, Paul Murray, Mark W. Towers

Publikováno v: International Journal of Mass Spectrometry, 437, 38-48. Elsevier
International Journal of Mass Spectrometry

The clinical use of mass spectrometry imaging (MSI) is rapidly growing, and applications are expanding. Crucially, the analysis of clinical cohorts requires a combination of higher analytical throughput and higher lateral resolution. Here, we demonst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02527aa12f51b61478843c52f1f85412
https://doi.org/10.1016/j.ijms.2018.09.015

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Optimised Desorption Electrospray Ionisation Mass Spectrometry Imaging (DESI-MSI) for the Analysis of Proteins/Peptides Directly from Tissue Sections on a Travelling Wave Ion Mobility Q-ToF

Autor: Tamás Karancsi, Steven Derek Pringle, Emmanuelle Claude, Emrys A. Jones, Mark W. Towers

Publikováno v: Journal of the American Society for Mass Spectrometry

Desorption electrospray ionisation mass spectrometry imaging (DESI-MSI) is typically known for the ionisation of small molecules such as lipids and metabolites, in singly charged form. Here we present a method that allows the direct detection of prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa75e61a886e63f7db21b2a73077a63
https://doi.org/10.1007/s13361-018-2049-0

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BASIS: High-performance bioinformatics platform for processing of large-scale mass spectrometry imaging data in chemically augmented histology

Autor: Emmanuelle Claude, James I. Langridge, Reza Mirnezami, Dieter Galea, Jonathan P. Sleeman, Zoltan Takats, Ivan Laponogov, Robert Tonge, Kirill Veselkov, Mark W. Towers, Jeremy K. Nicholson, Anna Mroz, Johannes P. C. Vissers

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific reports, 8 (1), Art.Nr.: 4053
Scientific Reports

Mass Spectrometry Imaging (MSI) holds significant promise in augmenting digital histopathologic analysis by generating highly robust big data about the metabolic, lipidomic and proteomic molecular content of the samples. In the process, a vast quanti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100446417b631c58ba357b4bad326c98
http://link.springer.com/article/10.1038/s41598-018-22499-z

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Lipidomics for translational skin research: A primer for the uninitiated

Autor: Emrys A. Jones, Michael Morris, Alexandra C. Kendall, Anna Nicolaou, Christopher E.M. Griffiths, Marta M Koszyczarek, Philippa J. Hart, Mark W. Towers

Publikováno v: Kendall, A C, Koszyczarek, M M, Jones, E A, Hart, P J, Towers, M, Griffiths, C E M, Morris, M & Nicolaou, A 2018, ' Lipidomics for translational skin research: a primer for the uninitiated ', Experimental Dermatology, vol. 27, no. 7, pp. 721-728 . https://doi.org/10.1111/exd.13558

Healthy skin depends on a unique lipid profile to form a barrier that confers protection and prevents excessive water loss, aids cell‐cell communication, and regulates cutaneous homeostasis and inflammation. Alterations in the cutaneous lipid profi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55300e4242607b967373c2135bc2f691
https://pubmed.ncbi.nlm.nih.gov/29654617

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In vivo isotopically labeled atherosclerotic aorta plaques in ApoE KO mice and molecular profiling by matrix-assisted laser desorption/ionization mass spectrometric imaging

Autor: Sheng-Ping Wang, Henry Shion, Douglas G. Johns, Vinit Shah, Nana Kofi Karikari, Michele A. Cleary, Karen O. Akinsanya, Jose Castro-Perez, John P. Shockcor, Vivienne Mendoza, Thomas P. Roddy, Mark W. Towers, David G. McLaren, Nathan G. Hatcher, Stephen F. Previs, Alan Millar

Publikováno v: Rapid Communications in Mass Spectrometry. 28:2471-2479

RATIONALE The ability to quantify rates of formation, regression and/or remodeling of atherosclerotic plaque should facilitate a better understanding of the pathogenesis and management of cardiovascular disease. In the current study, we coupled a sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3a7028b23d0864955ca640d15f27316
https://doi.org/10.1002/rcm.7039

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Enhanced capabilities for imaging gangliosides in murine brain with matrix-assisted laser desorption/ionization and desorption electrospray ionization mass spectrometry coupled to ion mobility separation

Autor: Karolina Škrášková, Ron M. A. Heeren, Mark W. Towers, Shane R. Ellis, Emrys A. Jones, Emmanuelle Claude

Publikováno v: Methods, 104, 69-78. Elsevier Science

The increased interest in lipidomics calls for improved yet simplified methods of lipid analysis. Over the past two decades, mass spectrometry imaging (MSI) has been established as a powerful technique for the analysis of molecular distribution of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a4cd8a04352bebc0a5123fa33bfe85
https://cris.maastrichtuniversity.nl/en/publications/ecf08a4b-0c6d-4c88-8612-dce93a2d5c43

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