Zobrazeno 1 - 10
of 140
pro vyhledávání: '"W. Todd Miller"'
Autor:
Patricia O. Benedet, Nooshin S. Safikhan, Maria J. Pereira, Bryan M. Lum, José Diego Botezelli, Cheng-Hsiang Kuo, Hua-Lin Wu, Barbara P. Craddock, W. Todd Miller, Jan W. Eriksson, Jessica T.Y. Yue, Edward M. Conway
Publikováno v:
EBioMedicine, Vol 99, Iss , Pp 104906- (2024)
Summary: Background: In spite of new treatments, the incidence of type 2 diabetes (T2D) and its morbidities continue to rise. The key feature of T2D is resistance of adipose tissue and other organs to insulin. Approaches to overcome insulin resistanc
Externí odkaz:
https://doaj.org/article/662c11ff3e454063835ffc5b1b5616ba
Autor:
Dhivya Sridaran, Surbhi Chouhan, Kiran Mahajan, Arun Renganathan, Cody Weimholt, Shambhavi Bhagwat, Melissa Reimers, Eric H. Kim, Manish K. Thakur, Muhammad A. Saeed, Russell K. Pachynski, Markus A. Seeliger, W. Todd Miller, Felix Y. Feng, Nupam P. Mahajan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Immune checkpoint blockade is showing promise in cancer immune therapy, but many solid tumours are resistant. Authors here identify a pathway in T cells that leads to increased activity of C-terminal Src kinase, a negative regulator of T cell activit
Externí odkaz:
https://doaj.org/article/7caeec47da1c4212a9d6e0933f20b457
Publikováno v:
Cells, Vol 12, Iss 6, p 900 (2023)
The nonreceptor tyrosine kinase (NRTK) Ack1 comprises a distinct arrangement of non-catalytic modules. Its SH3 domain has a C-terminal to the kinase domain (SH1), in contrast to the typical SH3-SH2-SH1 layout in NRTKs. The Ack1 is the only protein th
Externí odkaz:
https://doaj.org/article/4007c92046694eb7aee38ca451c20fbe
Autor:
W. Todd Miller
Publikováno v:
Biochemistry and Biophysics Reports, Vol 23, Iss , Pp 100775- (2020)
Homologous enzymes from different species display functional characteristics that correlate with the physiological and environmental temperatures encountered by the organisms. In this study, we have investigated the temperature sensitivity of the non
Externí odkaz:
https://doaj.org/article/09ad4ee88dc24bab9c7555111157186d
Autor:
Stephanie Guillet, Tomi Lazarov, Natasha Jordan, Bertrand Boisson, Maria Tello, Barbara Craddock, Ting Zhou, Chihiro Nishi, Rohan Bareja, Hairu Yang, Frederic Rieux-Laucat, Rosa Irene Fregel Lorenzo, Sabrina D Dyall, David Isenberg, David D'Cruz, Nico Lachmann, Olivier Elemento, Agnes Viale, Nicholas D Socci, Laurent Abel, Shigekazu Nagata, Morgan Huse, W Todd Miller, Jean-Laurent Casanova, Frédéric Geissmann
Publikováno v:
eLife, Vol 13 (2024)
Systemic lupus erythematosus (SLE) is an autoimmune disease, the pathophysiology and genetic basis of which are incompletely understood. Using a forward genetic screen in multiplex families with SLE, we identified an association between SLE and compo
Externí odkaz:
https://doaj.org/article/bbeacfc654b64900aa3479d5ae42195e
Publikováno v:
Biochemistry
Tyrosine kinases (TKs) play essential roles in signaling processes that regulate cell survival, migration, and proliferation. Dysregulation of tyrosine kinases underlies many disorders, including cancer, cardiovascular and developmental diseases, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56333481e9bd9ae52b2fb6b3f212fc8b
https://europepmc.org/articles/PMC10052838/
https://europepmc.org/articles/PMC10052838/
Publikováno v:
Chem Biol Drug Des
Human epidermal growth factor receptor 2 (HER2) is an oncogenic driver and key therapeutic target for human cancers. Current therapies targeting HER2 are primarily based on overexpression of the wild-type form of HER2. However, kinase domain mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8881da5b449825390514ee53c33bad82
https://europepmc.org/articles/PMC9879383/
https://europepmc.org/articles/PMC9879383/
Autor:
Yağmur Kan, W. Todd Miller
Publikováno v:
FEBS Lett
Ack1 is a proto-oncogenic tyrosine kinase with homology to the tumour suppressor Mig6, an inhibitor of the epidermal growth factor receptor (EGFR). The residues critical for binding of Mig6 to EGFR are conserved within the Mig6 homology region (MHR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5dde4747e46cfe44bbb65a5b021eed
https://pubmed.ncbi.nlm.nih.gov/36178070
https://pubmed.ncbi.nlm.nih.gov/36178070
Autor:
Sultan Ahmed, W. Todd Miller
Publikováno v:
The Journal of biological chemistry. 298(12)
Human Tnk1 (thirty-eight negative kinase 1) is a member of the Ack family of nonreceptor tyrosine kinases. Tnk1 contains a sterile alpha motif, a tyrosine kinase catalytic domain, an SH3 (Src homology 3) domain, and a large C-terminal region that con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ba2bef21089dc46eee4f59d595a837
https://pubmed.ncbi.nlm.nih.gov/36334623
https://pubmed.ncbi.nlm.nih.gov/36334623
Autor:
Dhivya, Sridaran, Surbhi, Chouhan, Kiran, Mahajan, Arun, Renganathan, Cody, Weimholt, Shambhavi, Bhagwat, Melissa, Reimers, Eric H, Kim, Manish K, Thakur, Muhammad A, Saeed, Russell K, Pachynski, Markus A, Seeliger, W Todd, Miller, Felix Y, Feng, Nupam P, Mahajan
Publikováno v:
Nature communications. 13(1)
Solid tumours are highly refractory to immune checkpoint blockade (ICB) therapies due to the functional impairment of effector T cells and their inefficient trafficking to tumours. T-cell activation is negatively regulated by C-terminal Src kinase (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bb1b95b6964351bd22a60b1250a08b69
https://pubmed.ncbi.nlm.nih.gov/36376335
https://pubmed.ncbi.nlm.nih.gov/36376335