Antigen specificity of anti-nuclear antibodies complexed to nucleosomes determines glomerular basement membrane binding in vivo

Autor: W. Tamboer, K. Kramers, Jhm Berden, Marc Monestier, Ruud J.T. Smeenk, T. P. M. Rijke, Gilbert J. Fournié, M. C. J. Van Bruggen, B. Walgreen

Publikováno v: European Journal of Immunology, 27, pp. 1564-1569
European Journal of Immunology, 27, 6, pp. 1564-1569
European Journal of Immunology, 27, 1564-1569

Monoclonal anti-nuclear antibodies which are complexed to nucleosomes are able to bind to the glomerular basement membrane (GBM) in vivo, whereas purified antibodies do not bind. The positively charged histone moieties in the nucleosome are-responsib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5113e92029be4fb0f51d66ad64f51f
https://hdl.handle.net/2066/25112