Zobrazeno 1 - 10
of 302
pro vyhledávání: '"W. Siebel"'
Publikováno v:
Climate of the Past, Vol 9, Iss 5, Pp 2347-2364 (2013)
We established a multi-proxy time series comprising analyses of major elements in bulk sediments, Sr and Nd isotopes, grain size of terrigenous fraction, and δ18O and δ13C in tests of Neogloboquadrina pachyderma (sinistral) from a marine sediment s
Externí odkaz:
https://doaj.org/article/c42a52fe216148c4866b59ebdb006206
Autor:
Syeda Nayab Fatima Abidi, Sara Chan, Kerstin Seidel, Daniel Lafkas, Louis Vermeulen, Frank Peale, Christian W Siebel
Publikováno v:
eLife, Vol 13 (2024)
The sebaceous gland (SG) is a vital appendage of the epidermis, and its normal homeostasis and function is crucial for effective maintenance of the skin barrier. Notch signaling is a well-known regulator of epidermal differentiation, and has also bee
Externí odkaz:
https://doaj.org/article/b8938d4290b54efa81d209aa64989f5b
Publikováno v:
Geologica Acta, Vol 6, Iss 4 (2009)
The Neoproterozoic rock assemblages in the Wadi Hafafit Culmination (WHC) can be subdivided into two main units which are separated by the Nugrus Thrust. The structurally higher Nugrus unit is mainly composed of low grade micaschists, metavolcanic, s
Externí odkaz:
https://doaj.org/article/c2031f30bdcb4556ba04f3764ac568d4
Autor:
Nobukatsu Horita, Theresa M. Keeley, Elise S. Hibdon, Elizabeth Delgado, Daniel Lafkas, Christian W. Siebel, Linda C. Samuelson
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 275-287 (2022)
Background & Aims: Notch pathway signaling maintains gastric epithelial cell homeostasis by regulating stem cell proliferation and differentiation. We previously identified NOTCH1 and NOTCH2 as the key Notch receptors controlling gastric stem cell fu
Externí odkaz:
https://doaj.org/article/c9c7c90acdba43d3b35b4515ca88e447
Autor:
Daniela Gómez Atria, Brian T. Gaudette, Jennifer Londregan, Samantha Kelly, Eric Perkey, Anneka Allman, Bhaskar Srivastava, Ute Koch, Freddy Radtke, Burkhard Ludewig, Christian W. Siebel, Russell J.H. Ryan, Tanner F. Robertson, Janis K. Burkhardt, Warren S. Pear, David Allman, Ivan Maillard
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 13 (2022)
In lymphopenic environments, secondary lymphoid organs regulate the size of B and T cell compartments by supporting the homeostatic proliferation of mature lymphocytes. The molecular mechanisms underlying these responses and their functional conseque
Externí odkaz:
https://doaj.org/article/aa88b4759e6e46808e2bc89a9767c5db
Autor:
Sushil Kumar, Ajeya Nandi, Snahlata Singh, Rohan Regulapati, Ning Li, John W. Tobias, Christian W. Siebel, Mario Andres Blanco, Andres J. Klein-Szanto, Christopher Lengner, Alana L. Welm, Yibin Kang, Rumela Chakrabarti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Although activated Notch receptors have been associated with chemoresistance in cancer, the role of specific Notch ligands remain elusive. Here, the authors show that in breast cells the Notch ligand DLL1 is expressed in cells with a cancer stem cell
Externí odkaz:
https://doaj.org/article/a82e2a88c87b4da18c5103c84eb99f0b
Autor:
Valeria Yartseva, Leonard D. Goldstein, Julia Rodman, Lance Kates, Mark Z. Chen, Ying-Jiun J. Chen, Oded Foreman, Christian W. Siebel, Zora Modrusan, Andrew S. Peterson, Ana Jovičić
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1491-1503.e6 (2020)
Summary: How satellite cells and their progenitors balance differentiation and self-renewal to achieve sustainable tissue regeneration is not well understood. A major roadblock to understanding satellite cell fate decisions has been the difficulty of
Externí odkaz:
https://doaj.org/article/369f10c9eb574d9880366d27d4b09e96
Autor:
Erika López-Arribillaga, Verónica Rodilla, Carlota Colomer, Anna Vert, Amy Shelton, Jason H. Cheng, Bing Yan, Abel Gonzalez-Perez, Melissa R. Junttila, Mar Iglesias, Ferran Torres, Joan Albanell, Alberto Villanueva, Anna Bigas, Christian W. Siebel, LLuís Espinosa
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
In intestinal adenomas carrying active β-catenin, Jagged1 (Jag1) ligand is responsible for Notch1 activation. Here, the authors show the reliance of Notch on Jag1 in cancer, and investigate how Jag1–Notch1 signaling interference may provide therap
Externí odkaz:
https://doaj.org/article/5d2954b26f864ba8adc0c8b369f6670f
Akademický článek
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Autor:
Elise S. Hibdon, Elizabeth Delgado, Nobukatsu Horita, Theresa M. Keeley, Daniel Lafkas, Linda C. Samuelson, Christian W. Siebel
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 275-287 (2022)
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 1, Pp 275-287 (2022)
Background & Aims Notch pathway signaling maintains gastric epithelial cell homeostasis by regulating stem cell proliferation and differentiation. We previously identified NOTCH1 and NOTCH2 as the key Notch receptors controlling gastric stem cell fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccacea6aeb7ccb4eac58ae85430d9382
https://doi.org/10.1016/j.jcmgh.2021.08.012
https://doi.org/10.1016/j.jcmgh.2021.08.012