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Akademický článek

An improved procedure for the preparation of Ru(bpz)3(PF6)2 via a high-yielding synthesis of 2,2’-bipyrazine

Autor: Danielle M. Schultz, James W. Sawicki, Tehshik P. Yoon

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 61-65 (2015)

There has been a recent surge of interest in the use of transition metal polypyridyl complexes as visible light-absorbing photocatalysts for synthetic applications. Among the most attractive features of this approach is the availability of many known

Externí odkaz: https://doaj.org/article/f080dad5e4104ebc92c61394ec4037b9

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High-Throughput Intact Protein Analysis for Drug Discovery Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry

Autor: Fan Pu, Scott A. Ugrin, Andrew J. Radosevich, David Chang-Yen, James W. Sawicki, Nari N. Talaty, Nathaniel L. Elsen, Jon D. Williams

Publikováno v: Analytical chemistry. 94(39)

Mass spectrometry (MS) is the primary analytical tool used to characterize proteins within the biopharmaceutical industry. Electrospray ionization (ESI) coupled to liquid chromatography (LC) is the current gold standard for intact protein analysis. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcdf4442c6d50c7f817dec31bdee3dff
https://pubmed.ncbi.nlm.nih.gov/36129783

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Akademický článek

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Akademický článek

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High-Throughput Label-Free Biochemical Assays Using Infrared Matrix-Assisted Desorption Electrospray Ionization Mass Spectrometry

Autor: Nathaniel L. Elsen, Sujatha M. Gopalakrishnan, David Chang-Yen, Andrew J. Radosevich, James W. Sawicki, Jon D. Williams, Fan Pu, Nari Talaty

Publikováno v: Analytical Chemistry. 93:6792-6800

Mass spectrometry (MS) can provide high sensitivity and specificity for biochemical assays without the requirement of labels, eliminating the risk of assay interference. However, its use had been limited to lower-throughput assays due to the need for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cde58dd559d38ee66484fb748cc1c54
https://doi.org/10.1021/acs.analchem.1c00737

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Ultrahigh-Throughput Ambient MS: Direct Analysis at 22 Samples per Second by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry

Autor: Jeffery Y. Pan, James W. Sawicki, Nathaniel L. Elsen, Nari Talaty, Jon D. Williams, Andrew J. Radosevich, Fan Pu, David Chang-Yen

Infrared Matrix-Assisted Laser Desorption Electrospray Ionization (IR-MALDESI) mass spectrometry is an ambient-direct sampling method being developed for high-throughput, label-free, biochemical screening of large-scale compound libraries. Here, we r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfefd4def7d9733737103c54b6fce142
https://doi.org/10.1101/2021.10.25.465730

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P4 Use of the 1-minute sit to stand test in patients presenting with suspected Covid-19 to assess need for hospital admission

Autor: N Maryanji, E Wilson, W Sawicki, A Key, DG Wooton, Paul Walker, J Rathore, Lewis Jones, G Jones, R Abraham

Publikováno v: Lessons from COVID-19

Introduction The clinical presentation of Covid-19 varies widely with only a small proportion of those infected requiring hospitalisation The ability to risk stratify patients upon presentation to the Emergency Department (ED) facilitates early safe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052825f178744f69365216d950448070
https://doi.org/10.1136/thorax-2020-btsabstracts.149

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