Zobrazeno 1 - 10 of 59 pro vyhledávání: '"W. S. T. Griffin"'
1
The neuroinflammatory response in humans after traumatic brain injury
Autor: Colin Smith, L. S. Murray, Pascale D. Leclercq, David I. Graham, James A. R. Nicoll, W. S. T. Griffin, Steve M. Gentleman
Publikováno v: Neuropathology and Applied Neurobiology. 39:654-666
Aims: Traumatic brain injury is a significant cause of morbidity and mortality worldwide. An epidemiological association between head injury and long-term cognitive decline has been described for many years and recent clinical studies have highlighte
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::996c3eb366f62941d03dc8556cc4af7d
https://doi.org/10.1111/nan.12008
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4
Overexpression of the Neurotrophic Cytokine S100β in Human Temporal Lobe Epilepsy
Autor: W. S. T. Griffin, J. G. Sheng, B. A. Burnett, Frederick A. Boop, Cynthia R. Rovnaghi, Robert E. Mrak, O. Yeralan, A. Feoktistova, L. J. Van Eldik
Publikováno v: Journal of Neurochemistry. 65:228-233
Neuritic sprouting and disturbances of calcium homeostasis are well described in epilepsy. S100 beta is an astrocyte-derived cytokine that promotes neurite growth and induces increases in levels of intracellular calcium in neurons. In sections of neo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e60c24683b48e9c451142c8fa913260
https://doi.org/10.1046/j.1471-4159.1995.65010228.x
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5
S100β Induction of the Proinflammatory Cytokine Interleukin-6 in Neurons
Autor: Steven W. Barger, Yuekui Li, Robert E. Mrak, Ling Liu, W. S. T. Griffin
Publikováno v: Journal of Neurochemistry. 74:143-150
Levels of the neurotrophic cytokine S100beta and the proinflammatory cytokine interleukin-6 (IL-6) are both elevated in Alzheimer's brain, and both have been implicated in beta-amyloid plaque formation and progression. We used RT-PCR and electrophore
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5dd31c23228ff5bd0b45c8e069c183f
https://doi.org/10.1046/j.1471-4159.2000.0740143.x
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6
Interleukin-1 Promotes Expression and Phosphorylation of Neurofilament and tau Proteins in Vivo
Autor: W. S. T. Griffin, Richard A. Jones, Robert E. Mrak, J. G. Sheng, S. G. Zhu
Publikováno v: Experimental Neurology. 163:388-391
Slow-release, IL-1-impregnated pellets implanted in rat cerebral cortex to simulate chronic overexpression of IL-1 significantly increased relative tissue levels of tau mRNA and of tau immunoreactivity in neuronal cell bodies and in swollen dystrophi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5535d495a209587ad5010dd005c31839
https://doi.org/10.1006/exnr.2000.7393
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7
Increased lnterleukin-1β Converting Enzyme Expression and Activity in Alzheimer Disease
Autor: Robert E. Mrak, S. G. Zhu, R. A. Jones, X. Q. Zhou, W. S. T. Griffin, J. G. Sheng, M. M. Brewer
Publikováno v: Journal of Neuropathology and Experimental Neurology. 58:582-587
Increased expression of interleukin-1 in Alzheimer disease (AD) has been implicated as a driving force in neurodegenerative cascades that underlie the formation of neuritic plaques and neurofibrillary tangles, the spread of these neuropathological le
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c741ee1787a3475d4356b77fca8b052f
https://doi.org/10.1097/00005072-199906000-00002
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8
Progressive Neuronal Injury Associated with Amyloid Plaque Formation in Alzheimer Disease
Autor: J. G. Sheng, W. S. T. Griffin, Xue Q. Zhou, Robert E. Mrak
Publikováno v: Journal of Neuropathology and Experimental Neurology. 57:714-717
Neuronal injury associated with amyloid plaque progression in Alzheimer disease was examined using TUNEL combined with beta-amyloid immunolabeling. There was a progressive increase in the frequency of TUNEL-positive neurons associated with plaque typ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad92485de524eb8fc1cab88f18a8607e
https://doi.org/10.1097/00005072-199807000-00008
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9
Enlarged and phagocytic, but not primed, interleukin-1α-immunoreactive microglia increase with age in normal human brain
Autor: W. S. T. Griffin, J. G. Sheng, Robert E. Mrak
Publikováno v: Acta Neuropathologica. 95:229-234
Microglia-mediated inflammatory responses have been implicated in the pathogenesis of neuritic plaques in Alzheimer's disease. The strong age association of Alzheimer's disease incidence suggests that events in normal aging may promote such responses
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf61fd7bfda6bbf89076c41ee25b537
https://doi.org/10.1007/s004010050792
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10
Glial-Neuronal Interactions in Alzheimer Disease
Autor: J. G. Sheng, W. S. T. Griffin, Robert E. Mrak
Publikováno v: Journal of Neuropathology and Experimental Neurology. 56:285-290
Activated microglia, overexpressing interleukin-1 (IL-1), and activated astrocytes, overexpressing S100beta, have been implicated in the formation and evolution of tau2-immunoreactive (tau2+) neuritic plaques in Alzheimer disease. In this study, we a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97c0d9d2a8a382efb0c61dbd54e5f30e
https://doi.org/10.1097/00005072-199703000-00007
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