Zobrazeno 1 - 10
of 20
pro vyhledávání: '"W. S. Dynan"'
Autor:
E. M. Kennedy, D. R. Powell, Z. Li, J. S. K. Bell, B. G. Barwick, H. Feng, M. R. McCrary, B. Dwivedi, J. Kowalski, W. S. Dynan, K. N. Conneely, P. M. Vertino
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Human deep space and planetary travel is limited by uncertainties regarding the health risks associated with exposure to galactic cosmic radiation (GCR), and in particular the high linear energy transfer (LET), heavy ion component. Here we a
Externí odkaz:
https://doaj.org/article/f87b1595000d46c19a007139a1f7607b
Autor:
M. F. Kubik, J. P. Hoeffler, M.-A. H. Matthews, Audrey A. Franklin, Martine N. Uittenbogaard, Jennifer K. Nyborg, Pongsak Utaisincharoen, W. S. Dynan, Anne Brauweiler
Publikováno v:
Journal of Biological Chemistry. 268:21225-21231
The human T-cell leukemia virus type I (HTLV-I)-encoded transcriptional activator protein Tax is strongly implicated in HTLV-I pathogenesis. Tax regulates HTLV-I gene expression through three 21-base pair (bp) repeat enhancer elements located in the
Autor:
Y Sui, Stephen C. Peiper, Shiqin Xiong, W S Dynan, Zheqiong Yang, K L Blanchard, Dorothy Tuan, L Ko, L Zhang
Publikováno v:
Oncogene
CoAA is an RRM-containing transcriptional coactivator that stimulates transcriptional activation and regulates alternative splicing. We show that the CoAA gene is amplified at the chromosome 11q13 locus in a subset of primary human cancers including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba89f1036f717f29d650dfdb96b82c80
https://europepmc.org/articles/PMC9245580/
https://europepmc.org/articles/PMC9245580/
Publikováno v:
The Journal of biological chemistry. 274(28)
Ku protein binds broken DNA ends, triggering a double-strand DNA break repair pathway. The spatial arrangement of the two Ku subunits in the initial Ku-DNA complex, when the Ku protein first approaches the broken DNA end, is not well defined. We have
Publikováno v:
Arthritis and rheumatism. 41(11)
Monoclonal antibody (mAb) F78 recognizes a heat-labile particle composed of Sm core proteins designated F78P. The objective of this study was to identify human autoantibodies recognizing the conformational structure of F78P.Immunoblots using HeLa cel
Publikováno v:
Journal of cellular biochemistry. 67(1)
The activation of heat shock transcription factor-1 (HSF-1) after treatment of mammalian cells with stresses such as heat shock, heavy metals, or ethanol induces the synthesis of heat shock proteins. HSF-1 is phosphorylated at normal growth temperatu
Publikováno v:
Cancer research. 57(8)
The binding of the Ku protein to DNA was investigated using the atomic force microscope. Ku was found to bind predominantly to the ends of double-stranded DNA. Experiments with plasmid DNA revealed that Ku does not bind to circular plasmids but does
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 158(5)
The DNA-dependent protein kinase (DNA-PK) is a serine/threonine kinase linked to DNA repair and V(D)J recombination. It is composed of a 460-kDa catalytic subunit (DNA-PKcs) and a 70/86-kDa heterodimeric regulatory component that is identical with th
Autor:
A A, Franklin, M F, Kubik, M N, Uittenbogaard, A, Brauweiler, P, Utaisincharoen, M A, Matthews, W S, Dynan, J P, Hoeffler, J K, Nyborg
Publikováno v:
The Journal of biological chemistry. 268(28)
The human T-cell leukemia virus type I (HTLV-I)-encoded transcriptional activator protein Tax is strongly implicated in HTLV-I pathogenesis. Tax regulates HTLV-I gene expression through three 21-base pair (bp) repeat enhancer elements located in the
Publikováno v:
The Journal of biological chemistry. 268(14)
We have recently shown that a template-associated protein kinase, which phosphorylates the carboxyl-terminal domain (CTD) of RNA polymerase II, is a two-component system. We describe here the purification of these two components to apparent homogenei