Zobrazeno 1 - 10
of 195
pro vyhledávání: '"W. Ruddock"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Fibulin-2 is a multidomain, disulfide-rich, homodimeric protein which belongs to a broader extracellular matrix family. It plays an important role in the development of elastic fiber structures. Malfunction of fibulin due to mutation or poor
Externí odkaz:
https://doaj.org/article/07b6c39d37bc4aaba300f8dc23304b3f
Autor:
Anna Drożdż, Brian Duggan, Mark W. Ruddock, Cherith N. Reid, Mary Jo Kurth, Joanne Watt, Allister Irvine, John Lamont, Peter Fitzgerald, Declan O’Rourke, David Curry, Mark Evans, Ruth Boyd, Jose Sousa
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundDetailed and invasive clinical investigations are required to identify the causes of haematuria. Highly unbalanced patient population (predominantly male) and a wide range of potential causes make the ability to correctly classify patients
Externí odkaz:
https://doaj.org/article/0dfdf9a298f5453eb5cad9481dbb72da
Autor:
Aatir A. Tungekar, Lloyd W. Ruddock
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract With increased accessibility and tissue penetration, smaller antibody formats such as antibody fragments (Fab) and single chain variable fragments (scFv) show potential as effective and low-cost choices to full-length antibodies. These forma
Externí odkaz:
https://doaj.org/article/d963382c805f4fb783fd7803dab4c2b2
Publikováno v:
Frontiers in Drug Safety and Regulation, Vol 3 (2023)
Introduction: The COVID-19 pandemic has caused a significant increase in mental health issues which general practitioners are now witnessing and managing in communities across Northern Ireland. Unfortunately, this new tsunami of patients with mental
Externí odkaz:
https://doaj.org/article/8ee5cd6b0c564420bd7e091766a21b47
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Global health challenges such as the coronavirus pandemic warrant the urgent need for a system that allows efficient production of diagnostic and therapeutic interventions. Antibody treatments against SARS-CoV-2 were developed with an unprec
Externí odkaz:
https://doaj.org/article/90b7d1ca49914b27b9d29dd9dd4f78b5
Publikováno v:
MicrobiologyOpen, Vol 12, Iss 2, Pp n/a-n/a (2023)
Abstract High‐value heterologous proteins produced in Escherichia coli that contain disulfide bonds are almost invariably targeted to the periplasm via the Sec pathway as it, among other advantages, enables disulfide bond formation and simplifies d
Externí odkaz:
https://doaj.org/article/a1e396970f3548a29fe9d0d343ba4aa0
Autor:
Agnes Awuah, Julie S. Moore, M. Andrew Nesbit, Mark W. Ruddock, Paul F. Brennan, Jonathan A. Mailey, Andrew J. McNeil, Min Jing, Dewar D. Finlay, Emanuele Trucco, Mary Jo Kurth, Joanne Watt, John V. Lamont, Peter Fitzgerald, Mark S. Spence, James A. D. McLaughlin, Tara C. B. Moore
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Microvascular haemodynamic alterations are associated with coronary artery disease (CAD). The conjunctival microcirculation can easily be assessed non-invasively. However, the microcirculation of the conjunctiva has not been previously explo
Externí odkaz:
https://doaj.org/article/819b982c328e4d88997abe11eceb67ad
Autor:
Carla Harkin, Diego Cobice, Joanne Watt, Mary Jo Kurth, Simon Brockbank, Stephanie Bolton, Frances Johnston, Anna Strzelecka, John V. Lamont, Tara Moore, Peter Fitzgerald, Mark W. Ruddock
Publikováno v:
Frontiers in Nutrition, Vol 9 (2023)
IntroductionDiabetes is a major public health issue that is approaching epidemic proportions globally. Diabetes mortality is increasing in all ethnic groups, irrespective of socio-economic class. Obesity is often seen as the main contributor to an in
Externí odkaz:
https://doaj.org/article/86f893464bb6447c99bdc2096402a0c7
Autor:
William T. McBride, Mary Jo Kurth, Anna Domanska, Joanne Watt, Gavin McLean, Jijin Joseph, John V. Lamont, Peter Fitzgerald, Mark W. Ruddock
Publikováno v:
BMC Nephrology, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Increased perioperative pro-inflammatory biomarkers, renal hypoperfusion and ischemia reperfusion injury (IRI) heighten cardiac surgery acute kidney injury (CS-AKI) risk. Increased urinary anti-inflammatory cytokines attenuate ris
Externí odkaz:
https://doaj.org/article/a044d7338a22474aa1aaee728a9c327f
Autor:
Joanne Watt, Mary Jo Kurth, Cherith N. Reid, John V. Lamont, Peter Fitzgerald, Mark W. Ruddock
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Introduction: Non-alcoholic fatty liver disease (NAFLD) is a condition where excess fat accumulates in the liver (hepatic steatosis) and there is no history of alcohol abuse or other secondary causes of chronic liver disease. NAFLD is a very common d
Externí odkaz:
https://doaj.org/article/634224a19f4b4336afcaba17cea70288