Zobrazeno 1 - 10
of 70
pro vyhledávání: '"W. Rattay"'
Vitamin D3 deficiency and osteopenia in spastic paraplegia type 5 indicate impaired bone homeostasis
Autor:
Sabrina Ehnert, Stefan Hauser, Holger Hengel, Philip Höflinger, Rebecca Schüle, Tobias Lindig, Jonathan Baets, Tine Deconinck, Peter de Jonghe, Tina Histing, Andreas K. Nüssler, Ludger Schöls, Tim W. Rattay
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Hereditary spastic paraplegia type 5 (SPG5) is an autosomal recessively inherited movement disorder characterized by progressive spastic gait disturbance and afferent ataxia. SPG5 is caused by bi-allelic loss of function mutations in CYP7B1
Externí odkaz:
https://doaj.org/article/0838cc419332405ab3daed3ea2d41e47
Autor:
Anna Hofmann, Corinna Blum, Constanze Single, Kamal Adeyemi, Patricia Schwarz, Vasileios Siokas, Tim W. Rattay, Helene A. Häberle, Reimer Riessen, Bettina Brendel, Iris Haug, Ruth Bösel, Manola Zago, Peter Martus, Ulf Ziemann, Annerose Mengel, Katharina Feil
Publikováno v:
BMC Neurology, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract Background Persisting coma is a common complication in (neuro)intensive care in neurological disease such as acute ischemic stroke, intracerebral hemorrhage or subarachnoid hemorrhage. Amantadine acts as a nicotinic receptor antagonist, dopa
Externí odkaz:
https://doaj.org/article/da8fb319564f4ec7ae1d21a63ffa41bb
Dysfunctional neuro-muscular mechanisms explain gradual gait changes in prodromal spastic paraplegia
Autor:
Christian Lassmann, Winfried Ilg, Tim W. Rattay, Ludger Schöls, Martin Giese, Daniel F. B. Haeufle
Publikováno v:
Journal of NeuroEngineering and Rehabilitation, Vol 20, Iss 1, Pp 1-19 (2023)
Abstract Background In Hereditary Spastic Paraplegia (HSP) type 4 (SPG4) a length-dependent axonal degeneration in the cortico-spinal tract leads to progressing symptoms of hyperreflexia, muscle weakness, and spasticity of lower extremities. Even bef
Externí odkaz:
https://doaj.org/article/922b97fb95b94dc6a54c0d6b5172dac1
Autor:
Tobias Lindig, Benjamin Bender, Eva Bürkle, Vinod Kumar, Ulrike Ernemann, Ludger Schöls, Tim W. Rattay
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Usage of MR imaging biomarkers is limited to experts. Automatic quantitative reports provide access for clinicians to data analysis. Automated data analysis was tested for usability in a small cohort of patients with hereditary spastic parap
Externí odkaz:
https://doaj.org/article/f42734c6ae31422eb778d063e7e746c3
Autor:
Christoph Kessler, Lina Maria Serna‐Higuita, Carlo Wilke, Tim W. Rattay, Holger Hengel, Jennifer Reichbauer, Elke Stransky, Alejandra Leyva‐Gutiérrez, David Mengel, Matthis Synofzik, Ludger Schöls, Peter Martus, Rebecca Schüle
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 3, Pp 326-338 (2022)
Abstract Objective While the anticipated rise of disease‐modifying therapies calls for reliable trial outcome parameters, fluid biomarkers are lacking in spastic paraplegia type 4 (SPG4), the most prevalent form of hereditary spastic paraplegia. We
Externí odkaz:
https://doaj.org/article/e486999379b24183b41eee1550e73be9
Publikováno v:
Neurological Research and Practice, Vol 3, Iss 1, Pp 1-4 (2021)
Abstract A 53-year old male with a history of progressive visual impairment, hearing loss, peripheral neuropathy, poorly controlled diabetes mellitus, cardiomyopathy, and weight loss was referred to the rare disease center due to the suspicion of mit
Externí odkaz:
https://doaj.org/article/94ff1c886cd24bcdb727ba9edb01b240
Autor:
Christoph Kessler, Lina M. Serna‐Higuita, Tim W. Rattay, Walter Maetzler, Isabel Wurster, Stefanie Hayer, Carlo Wilke, Holger Hengel, Jennifer Reichbauer, Marcel Armbruster, Ludger Schöls, Peter Martus, Rebecca Schüle
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 5, Pp 1122-1131 (2021)
Abstract Objective Despite the need for diagnostics and research, data on fluid biomarkers in hereditary spastic paraplegia (HSP) are scarce. We, therefore, explore Neurofilament light chain (NfL) levels in cerebrospinal fluid (CSF) of patients with
Externí odkaz:
https://doaj.org/article/e37dca3c7cf44d68bf61cfd8c392dcf6
Autor:
Tim W. Rattay, Pascal Martin, Debora Vittore, Holger Hengel, Idil Cebi, Johannes Tünnerhoff, Maria-Ioanna Stefanou, Jonatan F. Hoffmann, Katrin von der Ehe, Johannes Klaus, Julia Vonderschmitt, Matthias L. Herrmann, Paula Bombach, Hazar Al Barazi, Lena Zeltner, Janina Richter, Klaus Hesse, Kathrin N. Eckstein, Stefan Klingberg, Dirk Wildgruber
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract In current international classification systems (ICD-10, DSM5), the diagnostic criteria for psychotic disorders (e.g. schizophrenia and schizoaffective disorder) are based on symptomatic descriptions since no unambiguous biomarkers are known
Externí odkaz:
https://doaj.org/article/cf0456f8e57040f6b7125be98595951c
Autor:
Tobias Lindig, Christer Ruff, Tim W. Rattay, Stephan König, Ludger Schöls, Rebecca Schüle, Thomas Nägele, Ulrike Ernemann, Uwe Klose, Benjamin Bender
Publikováno v:
NeuroImage: Clinical, Vol 36, Iss , Pp 103213- (2022)
Spinal diffusion tensor imaging (sDTI) is still a challenging technique for selectively evaluating anatomical areas like the pyramidal tracts (PT), dorsal columns (DC), and anterior horns (AH) in clinical routine and for reliably quantifying white ma
Externí odkaz:
https://doaj.org/article/4f5978dd6c234319908d8bb4fddedead
Autor:
Tim W. Rattay, Jennifer Just, Benjamin Röben, Holger Hengel, Rebecca Schüle, Matthis Synofzik, Anne S. Söhn, Natalie Winter, Nele Dammeier, Ludger Schöls, Alexander Grimm
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 13, Iss 1, Pp 1-7 (2018)
Abstract Objective High-resolution nerve ultrasound (HRUS) is a painless tool to quickly evaluate peripheral nerve morphology in vivo. This study set out to characterize peripheral nerve involvement in X-linked adrenomyeloneuropathy (AMN) by HRUS. Me
Externí odkaz:
https://doaj.org/article/4183a8e16cef48e38a581ce04002e586