Zobrazeno 1 - 10
of 11
pro vyhledávání: '"W. R. Rush"'
Publikováno v:
CNS Drug Reviews. 1:149-167
Publikováno v:
Rapid communications in mass spectrometry : RCM. 9(14)
The metabolism of ranolazine (RS-43285) or (+)N-(2,6-dimethylphenyl)-4[2-hydroxy-3-(2-methoxyphenoxy)-propyl]-1- piperazine acetamide dihydrochloride was investigated in man using plasma samples obtained from four different clinical studies. The meta
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 18(4)
The comparative steady-state bioavailability of asiatic acid was studied in 12 healthy male and female volunteers following oral administration of approximately equimolar doses of either asiatic acid (12 mg) or the glycoside derivative of asiatic aci
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 22(2)
1. The metabolism of imiloxan hydrochloride [(+-)-2-(1-ethyl-2-imidazoyl)methyl-1,4-benzodioxane hydrochloride], an alpha 2-adrenoceptor antagonist, was studied in four male volunteers given a 500 mg oral dose containing 0.48 MBq of the 14C-labelled
Autor:
J. F. Nicholas, J. Fuller, T. C. Frewen, R. Lee, L. M. Broadman, I. E. Soliman, R. S. Hannallah, W. A. McGill, S. Tsuneto, M. Yamashita, Y. Miyamoto, J. M. Badgwell, M. E. McLeod, J. Lerman, R. E. Creighton, D. O’Toole, S. M. McCarroll, M. Peyton, AJ. Cunningham, J. G. Ramsay, B. Rajagopalan, E. Harmsen, P. Bore, P. Foëx, G. Radda, G. A. Blaise, S. G. Lenis, C. Sill, P. Vanhoutte, C. L. Irish, J. M. Murkin, G. M Guiraudon, R. J. Martineau, S. G. Nadeau, C. J. Montgomery, D. J. Steward, D. C. Chung, A. M. Lam, D. M. Grace, K. Gordon, T. Thompson, F. Donati, J. Lahoud, J. R. D. Laycock, D. R. Bevan, J. P. O’Connor, RE. Ralley, J. M. Katz, M. H. Sami, J. E. Wynands, CE. Smith, M. K. Baxter, J. C. Bevan, S. Sangwan, C. Tang, A. W. Gelb, D. P. Boisvert, E. Marchak, A. Lunt, R. Dowman, N. Cowie, R. Kozody, W. P. S. McKay, W. H. Noble, W. J. Taylor, M. C. Champion, A. W. Barry, IB. Hurtig, A. Beland, C. Hollmann, R. Meloche, K. R. A. Ringaert, W. A. C. Mutch, H. Vaghadia, M. T. Schechter, S. B. Sheps, L. C. Jenkins, G. C. Allen, C. B. Cattran, R. G. Peterson, M. J. Ali, R. J. Byrick, T. A. Salerno, C. B. Baker, S. V. Lichtenstein, M. J. Sharpe, R. Merchant, W. Alyafi, D. H. Penning, K. Jhamandas, M. Weingarten, D. P. Strum, E. I. Eger II, T. M. Gallagher, G. A. Volgyesi, K. Miyasaka, F. A. Burrows, B. H. Johnson, M. R. Murphy, F. Szlam, C. C. Hug, D. C. Martin, J. F. Johnston, K. R. Levin, P. I. Silverstein, J. Pruett, B. Bissonnette, A. A. Scott, S. Halpem, O. Rosag, J. Swartz, R. I. Meeke, R. L. Knill, E. A. Rose, R. M. Soderman, B. Milne, F. Cervenko, C. Loomis, P. Murphy, A. N. Sandler, H. Vosu, L. C. Lau, R. Branson, R. A. Kearney, J. K. Rosales, W. J. Howes, A. R. Wolf, D. W. Fear, W. L. Roy, G. V. Goresky, T. D. E. Sharpe, MA. Sabourin, R. C. Polomeno, B. Ryan, R. Evelyn, T. T. Higgins, R. S. Hannal, M. H. DeSoto, S. S. Nason, J. P. Penning, C. W. Loomis, M. J. Douglas, G. H. McMorland, J. D. Gowan, J. B. Hurtig, R. A. Fraser, D. G. Whalley, P. Labrecque, D. Quance, C. A. Moote, P Y. K. Lok, M. I. Skinner, P. Y. K. Lok, W. A. C. Scott, D. Sielecka, P. D. Slinger, P. A. Lavelle, F. Chung, N. J. McDonald, S. McDonald, J. R. Maltby, A. Hutchinson, C. R. G. Reid, P. R. Whitaker, H. A. T. Hcin, R. J. Arellano, C. J. Cruise, P. Lokoff, WE. Code, L. Strunin, P. H. Manninen, M. S. P. Macnab, A. Lam, P. L. Houston, P. tavelle, R. Burns, R. I. Hall, K. C. Angert, D. A. Reeder, C. C. Moldenhauer, S. Teasdale, F. E. Ralley, E. A. Moffitt, D. J. O’Brien, D. D. Imrie, R. A. Barker, J. A. Sullivan, CE. Kinley, G. Block, G. Butlin, W. Sibbald, D. Cunningham, A. Sidi, W. R. Rush, R. F. Davis, R. G. Bergstrom, I. R. Thomson, M. Rosenbloom, R. C. Meatherall, F. J. Mensink, C. Maclntyre, J. G. Wade, M. Ghignone, N. Flynn, A. J. Cunningham, R. C. Hamilton, L. Beauregard, R. Martin, J. P. Tetrault, G. K. Johnstone, A. J. M. Clark, P. G. Houlton, I. E. Purkis, R. C. Shukla, F. J. Carmichael, V. Saldivia, H. Orrego, CA. Moote, M. Smith, H. F. Drake, T. Treasure, J. Olson, R. Strauss, H. Zetterstrom, L. O. Jonsson, R. B. Forbes, M. A. Albanese, D. J. Murray, W. A. Barcellos, P. Slinger, W. Triolet, J. Wilson, J. J. Berger, J. S. Gravenstein, G. McLaughlin, P. G. Boysen, G. L. Wolf, J. I. Simpson, D. Humphrey, J. G. Brock-Utne
Publikováno v:
Canadian Journal of Anaesthesia. 34:S55-S130
Autor:
P M Shaw, T S Barnes, D Cameron, J Engeset, W T Melvin, G Omar, J C Petrie, W R Rush, C P Snyder, P H Whiting, C R Wolf, M D Burke
Publikováno v:
Biochemical Journal. 263:653-663
A form of human hepatic microsomal cytochrome P-450 (P450hA7) with subunit Mr 50,400 has been purified from an epileptic who had been receiving long-term treatment with anticonvulsant drugs. P450hA7 metabolized the immunosuppressant drug cyclosporin
Publikováno v:
Biochemical pharmacology. 33(2)
Administration of BRL 26314 [N-(4-chlorobenzyl)-L-phenylalanine] raises circulating high-density lipoprotein (HDL) cholesterol and lowers total triglyceride levels in rats whether maintained on stock or semi-synthetic diets. HDL is also elevated by B
Publikováno v:
Biochemical pharmacology. 33(2)
Optimization of a combination of balloon catheter-induced aortic de-endothelialization with provision of a palatable atherogenic diet to rabbits leads to hyperbetalipoproteinaemia and atherosclerosis rather than to the cholesterol-storage disease whi
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 15(4)
Nafimidone, a candidate anticonvulsant agent, and its metabolite (nafimidone alcohol) demonstrated potent inhibition of hepatic drug metabolism in male rats. Inhibition occurred both in vivo following acute administration as a prolongation of hexobar
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 16(4)
Four human volunteers given a 30 mg oral dose of nicardipine hydrochloride containing 40 microCi of the 14C-labelled material achieved peak plasma levels of compound-related radioactivity within one hour of dosing. Parent compound comprised only a mi