Zobrazeno 1 - 5
of 5
pro vyhledávání: '"W. R. Prescott"'
Autor:
Raphael Mechoulam, P. J. Little, Billy R. Martin, W. R. Prescott, S. J. Ward, L S Melvin, M R Johnson, Brian F. Thomas, D R Compton, Raj K. Razdan
Publikováno v:
Pharmacology Biochemistry and Behavior. 40:471-478
Numerous cannabinoids have been synthesized that are extremely potent in all of the behavioral assays conducted in our laboratory. An important feature in increasing potency has been the substitution of a dimethylheptyl (DMH) side chain for the penty
Publikováno v:
Psychopharmacology. 107(1)
The cataleptogenic effect of delta 9-THC was compared to its discriminative stimulus effects in rats. The ED50s for the discriminative stimulus and catalepsy were 0.8 and 4.0 mg/kg, respectively, while their time courses were very similar. The ED50 o
Autor:
W R, Prescott, B R, Martin
Publikováno v:
NIDA research monograph. 105
Evaluation of ether and free hydroxyl analogs of delta-8, delta-9, 11-THC as cannabinoid antagonists
Publikováno v:
NIDA research monograph. 105
Publikováno v:
Molecular pharmacology. 38(6)
Structure-activity relationship studies have suggested that the phenolic hydroxyl group is essential for the pharmacological activity of the cannabinoids. However, it remains to be established whether it is the hydrogen of the phenolic hydroxyl that