Zobrazeno 1 - 10
of 286
pro vyhledávání: '"W. R. Harris"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Thanatin is a β-hairpin antimicrobial peptide cyclised by a single disulfide bond that has shown potent broad-spectrum activity towards bacterial and fungal pathogens. Towards Gram-negative species, thanatin acts both by forming trans-membranal pore
Externí odkaz:
https://doaj.org/article/287bc94011e1465898693298a480c6ed
Autor:
Tayla A. Rees, Benjamin J. Buttle, Zoe Tasma, Sung-Hyun Yang, Paul W. R. Harris, Christopher S. Walker
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Type 2 diabetes (T2D) and obesity are prevalent metabolic disorders affecting millions of individuals worldwide. A new effective therapeutic drug called tirzepatide for the treatment of obesity and T2D is a dual agonist of the GIP receptor and GLP-1
Externí odkaz:
https://doaj.org/article/0907ffccbaea49f58081214071b5e048
Autor:
Ghader Bashiri, Esther M. M. Bulloch, William R. Bramley, Madison Davidson, Stephanie M. Stuteley, Paul G. Young, Paul W. R. Harris, Muhammad S. H. Naqvi, Martin J. Middleditch, Michael Schmitz, Wei-Chen Chang, Edward N. Baker, Christopher J. Squire
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Poly-γ-glutamate tails are a distinctive feature of archaeal, bacterial, and eukaryotic cofactors, including the folates and F420. Despite decades of research, key mechanistic questions remain as to how enzymes successively add glutamates t
Externí odkaz:
https://doaj.org/article/4c044e76cc0a465894eb45f0998959cb
Publikováno v:
Antibiotics, Vol 13, Iss 7, p 615 (2024)
Capitellacin (1) is a 20-residue antimicrobial β-hairpin, produced by the marine polychaeta (segmented worms) Capitella teletai. Since its discovery in 2020, only very limited studies have been undertaken to understand capitellacin’s structure–a
Externí odkaz:
https://doaj.org/article/1c77f25f49b84955a3063602cb7d298c
Autor:
Samuel J. M. Hale, Alan J. Cameron, Christian A. Lux, Kristi Biswas, Raymond Kim, Mark O'Carroll, Paul W. R. Harris, Richard G. Douglas, Brett Wagner Mackenzie
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 2 (2024)
ABSTRACTPolymyxin B and ethylenediaminetetraacetic acid are antimicrobials possessing antibiofilm activity. They act by displacement and chelation, respectively, of divalent cations in bacterial membranes and may therefore act synergistically when ap
Externí odkaz:
https://doaj.org/article/9af11ee71eac456da674459f6553287e
Autor:
Dawei Ji, Jingying Ma, Junyi Dai, Min Xu, Paul W. R. Harris, Margaret A. Brimble, Dominic Agyei
Publikováno v:
Dairy, Vol 3, Iss 3, Pp 422-437 (2022)
The drug-likeness and pharmacokinetic properties of 23 dairy-protein-derived opioid peptides were studied using SwissADME and ADMETlab in silico tools. All the opioid peptides had poor drug-like properties based on violations of Lipinski’s rule-of-
Externí odkaz:
https://doaj.org/article/894335f97b88474ba669881a4f39a707
Publikováno v:
JACS Au, Vol 1, Iss 10, Pp 1527-1540 (2021)
Externí odkaz:
https://doaj.org/article/e3ffc8be592e42679615949dda8e92d8
Autor:
Sin Hang Crystal Chan, Jarred M. Griffin, Connor A. Clemett, Margaret A. Brimble, Simon J. O’Carroll, Paul W. R. Harris
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Peptide5 is a 12–amino acid mimetic peptide that corresponds to a region of the extracellular loop 2 (EL2) of connexin43. Peptide5 regulates both cellular communication with the cytoplasm (hemichannels) and cell-to-cell communication (gap junctions
Externí odkaz:
https://doaj.org/article/cf683c8288674cbf9ee0eb91ff0f3583
Autor:
Aqfan Jamaluddin, Chia-Lin Chuang, Elyse T. Williams, Andrew Siow, Sung Hyun Yang, Paul W. R. Harris, Jakeb S. S. M. Petersen, Rebekah L. Bower, Shanan Chand, Margaret A. Brimble, Christopher S. Walker, Debbie L. Hay, Kerry M. Loomes
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Signaling through calcitonin gene-related peptide (CGRP) receptors is associated with pain, migraine, and energy expenditure. Small molecule and monoclonal antibody CGRP receptor antagonists that block endogenous CGRP action are in clinical use as an
Externí odkaz:
https://doaj.org/article/087bc21e011f479b87b8311010e81136
Autor:
Shama Dissanayake, Junming He, Sung H. Yang, Margaret A. Brimble, Paul W. R. Harris, Alan J. Cameron
Publikováno v:
Molecules, Vol 28, Iss 4, p 1993 (2023)
Antimicrobial peptides (AMPs) hold promise as novel therapeutics in the fight against multi-drug-resistant pathogens. Cathelicidin-PY (NH2-RKCNFLCKLKEKLRTVITSHIDKVLRPQG-COOH) is a 29-residue disulfide-cyclised antimicrobial peptide secreted as an inn
Externí odkaz:
https://doaj.org/article/835b95e6798547208ebdf6c37d347946