Zobrazeno 1 - 10
of 212
pro vyhledávání: '"W. Pyerin"'
Publikováno v:
Cellular and Molecular Life Sciences. 63:2183-2190
Methionine and metabolites such as S-adenosylmethionine (AdoMet) are of vital importance for eukaryotes; AdoMet is the main donor of methyl groups and is involved in expression control of the methionine biosynthesis genes (MET genes). Genome-wide exp
Autor:
H. Grunicke, W. Pyerin, G. Eisenbrand, K. Havemann, H. M. Rabes, K. M�lling, M. Schwab, W. K. Lutz, J. Wahrendorf, V. Schirrmacher, K. Bosslet
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 120:179-185
Publikováno v:
The Journal of pathology. 214(5)
Osteocytes are the most abundant bone cells, playing important roles in tissue maintenance. Little is known of how they react in vivo to cancer stress. Here we present a comparative study of the effect of a bone-residing tumour (myeloma) and metastas
Publikováno v:
Molecular and cellular biochemistry. 227(1-2)
Protein kinase CK2, a tetramer composed of two catalytically active (CK2alpha isoforms) and two regulatory (CK2beta isoforms) subunits, is suspected to have, among others, a role in gene transcription. To identify the genes targeted by CK2, the trans
Autor:
W, Pyerin, K, Ackermann
Publikováno v:
Molecular and cellular biochemistry. 227(1-2)
Little is known of how protein kinase CK2 genes are regulated, and it is unclear whether there are mechanisms of transcriptional coordination. Response elements present in the promoter sequences of the human catalytic (CK2alpha) and regulatory (CK2be
Publikováno v:
Analytical Biochemistry. 210:421-423
Publikováno v:
European journal of biochemistry. 268(11)
Protein kinase CK2 is a conserved and vital Ser/Thr phosphotransferase with various links to malignant diseases, occurring as a tetramer composed of two catalytically active (CK2alpha and/or CK2alpha') and two regulatory subunits (CK2beta). There is
Publikováno v:
Journal of molecular biology. 293(5)
The nucleosome assembly protein-1 (NAP1) was originally identified in HeLa cells as a factor facilitating the in vitro assembly of nucleosomes. However, in yeast cells NAP1 is required in the control of mitotic events induced by the Clb2/p34(CDC28).
Publikováno v:
Molecular and cellular biochemistry. 191(1-2)
Human recombinant CK2 subunits were incubated for different times with the two main cytosolic proteases m-calpain and 20 S proteasome. Both, m-calpain in a calcium dependent manner and the 20 S proteasome, were able to degrade CK2 subunits in vitro.
Publikováno v:
Molecular and cellular biochemistry. 191(1-2)
Chemical crosslinking and analysis of CNBr-digested fusion products by immunoblotting with sequence-specific antibodies identifies an interaction between positions 55-70 of subunit beta (beta55-70) and 65-80 of subunit alpha (alpha65-80). This has be