Zobrazeno 1 - 10
of 209
pro vyhledávání: '"W. Prokop"'
Autor:
Jeremy W. Prokop, Sheryl Alberta, Martin Witteveen-Lane, Samantha Pell, Hosam A. Farag, Disha Bhargava, Robert M. Vaughan, Austin Frisch, Jacob Bauss, Humza Bhatti, Sanjana Arora, Charitha Subrahmanya, David Pearson, Austin Goodyke, Mason Westgate, Taylor W. Cook, Jackson T. Mitchell, Jacob Zieba, Matthew D. Sims, Adam Underwood, Habiba Hassouna, Surender Rajasekaran, Maximiliano A. Tamae Kakazu, Dave Chesla, Rosemary Olivero, Adam J. Caulfield
Publikováno v:
Microorganisms, Vol 12, Iss 9, p 1863 (2024)
As of 2024, SARS-CoV-2 continues to propagate and drift as an endemic virus, impacting healthcare for years. The largest sequencing initiative for any species was initiated to combat the virus, tracking changes over time at a full virus base-pair res
Externí odkaz:
https://doaj.org/article/985421ef6f7e4d43a817c091c93598f7
Publikováno v:
Insights into Imaging, Vol 14, Iss 1, Pp 1-7 (2023)
Abstract Objective An increasing number of commercial deep learning computer-aided detection (DL-CAD) systems are available but their cost-saving potential is largely unknown. This study aimed to gain insight into appropriate pricing for DL-CAD in di
Externí odkaz:
https://doaj.org/article/a3146910efb042dd947bc6a116e6f81d
Autor:
Claudia V. Aniol, Jeremy W. Prokop, Surender Rajasekaran, Spencer Pageau, Sydney K. Elizer, Elizabeth A. VanSickle, Caleb P. Bupp
Publikováno v:
BMC Pediatrics, Vol 23, Iss 1, Pp 1-4 (2023)
Abstract Background Noonan Syndrome is caused by variants in a variety of genes found in the RAS/MAPK pathway. As more causative genes for Noonan Syndrome have been identified, more phenotype variability has been found, particularly congenital heart
Externí odkaz:
https://doaj.org/article/5a8e17ed77eb4760af579bad5bea764b
Autor:
Marian L. Henderson, Jacob K. Zieba, Xiaopeng Li, Daniel B. Campbell, Michael R. Williams, Daniel L. Vogt, Caleb P. Bupp, Yvonne M. Edgerly, Surender Rajasekaran, Nicholas L. Hartog, Jeremy W. Prokop, Jena M. Krueger
Publikováno v:
BioTech, Vol 13, Iss 1, p 1 (2024)
Gene therapy holds promise as a life-changing option for individuals with genetic variants that give rise to disease. FDA-approved gene therapies for Spinal Muscular Atrophy (SMA), cerebral adrenoleukodystrophy, β-Thalassemia, hemophilia A/B, retina
Externí odkaz:
https://doaj.org/article/60765cdb5a054fb2909e7b2b14f2b561
Autor:
Wei Yu, Inamul Haque, Aparna Venkatraman, Heather L. Menden, Sherry M. Mabry, Badal C. Roy, Sheng Xia, Jeremy W. Prokop, Shahid Umar, Aron M. Geurts, Venkatesh Sampath
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 425-440 (2022)
Background & Aims: Single immunoglobulin interleukin-1–related receptor (SIGIRR) is a major inhibitor of Toll-like receptor signaling. Our laboratory identified a novel SIGIRR stop mutation (p.Y168X) in an infant who died of severe necrotizing ente
Externí odkaz:
https://doaj.org/article/3e60b8ebab2c43c9848fc4805b58f9b2
Autor:
Stephanie M. Bilinovich, Daniel L. Morris, Jeremy W. Prokop, Joel A. Caporoso, Alexandra Taraboletti, Nilubol Duangjumpa, Matthew J. Panzner, Leah P. Shriver, Thomas C. Leeper
Publikováno v:
Biophysica, Vol 1, Iss 4, Pp 359-376 (2021)
Glutaredoxins (GRXs) are a class of enzymes used in the reduction of protein thiols and the removal of reactive oxygen species. The CPYC active site of GRX is a plausible metal binding site, but was previously theorized not to bind metals due to its
Externí odkaz:
https://doaj.org/article/2be12093f9934e16a4b89ea09e9329e4
Autor:
Akansha S. Das, Emily C. Sherry, Robert M. Vaughan, Marian L. Henderson, Jacob Zieba, Katie L. Uhl, Olivia Koehn, Caleb P. Bupp, Surender Rajasekaran, Xiaopeng Li, Surya B. Chhetri, Sahar Nissim, Carol L. Williams, Jeremy W. Prokop
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The small GTPase family is well-studied in cancer and cellular physiology. With 162 annotated human genes, the family has a broad expression throughout cells of the body. Members of the family have multiple exons that require splicing. Yet, the role
Externí odkaz:
https://doaj.org/article/c07fd91f53d941d8a816a9e1ed070660
Autor:
Hannah C. Rudolph, April M. Stafford, Hye-Eun Hwang, Cheol-Hee Kim, Jeremy W. Prokop, Daniel Vogt
Publikováno v:
Biology, Vol 12, Iss 4, p 589 (2023)
Dysfunction of the WW domain-containing adaptor with coiled-coil, WAC, gene underlies a rare autosomal dominant disorder, DeSanto–Shinawi syndrome (DESSH). DESSH is associated with facial dysmorphia, hypotonia, and cognitive alterations, including
Externí odkaz:
https://doaj.org/article/e23290ef58b041a182ff5fd8d07ce059
Autor:
Gregory R. Keele, Jeremy W. Prokop, Hong He, Katie Holl, John Littrell, Aaron W. Deal, Yunjung Kim, Patrick B. Kyle, Esinam Attipoe, Ashley C. Johnson, Katie L. Uhl, Olivia L. Sirpilla, Seyedehameneh Jahanbakhsh, Melanie Robinson, Shawn Levy, William Valdar, Michael R. Garrett, Leah C. Solberg Woods
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Chronic kidney disease (CKD), which can ultimately progress to kidney failure, is influenced by genetics and the environment. Genes identified in human genome wide association studies (GWAS) explain only a small proportion of the heritable v
Externí odkaz:
https://doaj.org/article/6d41003b7a614d5f9d1574c3f69d76e1
CFTR-mediated monocyte/macrophage dysfunction revealed by cystic fibrosis proband-parent comparisons
Autor:
Xi Zhang, Camille M. Moore, Laura D. Harmacek, Joanne Domenico, Vittobai Rashika Rangaraj, Justin E. Ideozu, Jennifer R. Knapp, Katherine J. Woods, Stephanie Jump, Shuang Jia, Jeremy W. Prokop, Russell Bowler, Martin J. Hessner, Erwin W. Gelfand, Hara Levy
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
Cystic fibrosis (CF) is an inherited disorder caused by biallelic mutations of the CF transmembrane conductance regulator (CFTR) gene. Converging evidence suggests that CF carriers with only 1 defective CFTR copy are at increased risk for CF-related
Externí odkaz:
https://doaj.org/article/a63d56dde4aa4e118ea14046497fc7b7