Zobrazeno 1 - 10
of 1 089
pro vyhledávání: '"W. Pike"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The 2,2,2-trifluoroethoxy group increasingly features in drugs and potential tracers for biomedical imaging with positron emission tomography (PET). Herein, we describe a rapid and transition metal-free conversion of fluoroform with paraform
Externí odkaz:
https://doaj.org/article/30644c5756d942b890538d65ccd30767
Autor:
Huanyu Z. Li, Ashley C. W. Pike, Irina Lotsaris, Gamma Chi, Jesper S. Hansen, Sarah C. Lee, Karin E. J. Rödström, Simon R. Bushell, David Speedman, Adam Evans, Dong Wang, Didi He, Leela Shrestha, Chady Nasrallah, Nicola A. Burgess-Brown, Robert J. Vandenberg, Timothy R. Dafforn, Elisabeth P. Carpenter, David B. Sauer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and regulates the kinetics of signaling proteins. T
Externí odkaz:
https://doaj.org/article/32dcb0d22d77485888ff653efcd48c4e
Autor:
Karin E. J. Rödström, Alexander Cloake, Janina Sörmann, Agnese Baronina, Kathryn H. M. Smith, Ashley C. W. Pike, Jackie Ang, Peter Proks, Marcus Schewe, Ingelise Holland-Kaye, Simon R. Bushell, Jenna Elliott, Els Pardon, Thomas Baukrowitz, Raymond J. Owens, Simon Newstead, Jan Steyaert, Elisabeth P. Carpenter, Stephen J. Tucker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Potassium channels of the Two-Pore Domain (K2P) subfamily, KCNK1-KCNK18, play crucial roles in controlling the electrical activity of many different cell types and represent attractive therapeutic targets. However, the identification of high
Externí odkaz:
https://doaj.org/article/9ac3923cca8e4d1e92ffe481cfd471bf
Autor:
Sridhar Goud Nerella, Sanjay Telu, Jeih-San Liow, Madeline D. Jenkins, Sami S. Zoghbi, Juan L. Gomez, Michael Michaelides, Mark A. G. Eldridge, Barry J. Richmond, Robert B. Innis, Victor W. Pike
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Chemogenetic tools are designed to control neuronal signaling. These tools have the potential to contribute to the understanding of neuropsychiatric disorders and to the development of new treatments. One such chemogenetic technology compris
Externí odkaz:
https://doaj.org/article/dc85f38a8fc449c2a2f81a76b0068687
Autor:
Thomas W. Pike, Oliver H. P. Burman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Accurately quantifying an animal’s movement is crucial for developing a greater empirical and theoretical understanding of its behaviour, and for simulating biologically plausible movement patterns. However, we have a relatively poor under
Externí odkaz:
https://doaj.org/article/1bd4c67eab064501bdf865e767ea55da
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-6 (2023)
Abstract When observed in their preferred environments, animals display behavioural changes, such as an increase in resting or a reduction in agonism, suggestive of positive affect and improved welfare. However, most studies focus on the behaviour of
Externí odkaz:
https://doaj.org/article/9d9581a5b1c5458480c651fa938a1bab
Autor:
Lisheng Cai, Jeih-San Liow, Cheryl L. Morse, Sanjay Telu, Riley Davies, Lester S. Manly, Sami S. Zoghbi, Frederick T. Chin, Robert B. Innis, Victor W. Pike
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-11 (2023)
Key points Question: Do GluN2B radioligands 11C-NR2B-Me enantiomers show cross-binding with σ1 receptors in brain in vivo? Pertinent findings: 11C-(+)-NR2B-Me, 11C-(−)-NR2B-Me, 11C-(S)-NR2B-SMe, and 11C-(R)-NR2B-SMe give specific signals in whole
Externí odkaz:
https://doaj.org/article/0a8dea1580224d03a86adc98e17465ab
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1167 (2024)
The short-lived positron-emitter carbon-11 (t1/2 = 20.4 min; β+, 99.8%) is prominent for labeling tracers for use in biomedical research with positron emission tomography (PET). Carbon-11 is produced for this purpose with a cyclotron, nowadays almos
Externí odkaz:
https://doaj.org/article/54174c53f8314941a48efa7e2e2be562
Autor:
James Frederick W. Pike, Emily L. Polley, David Y. Pritchett, Arnav Lal, Blake A. Wynia, William E. Roudebush, Renee J. Chosed
Publikováno v:
Reproductive Health, Vol 18, Iss 1, Pp 1-8 (2021)
Plain Language Summary This review describes the detection of viruses in seminal fluid and their sexual transmission, focusing on the major viral outbreaks of Zika virus (ZIKV), Ebola virus (EBOV), severe acute respiratory syndrome (SARS)-coronavirus
Externí odkaz:
https://doaj.org/article/667e0cf3253c437cbf4c1196f85dbd2c
Autor:
Jae-Hoon Lee, Mattia Veronese, Jeih-San Liow, Cheryl L. Morse, Jose A. Montero Santamaria, Mohammad B. Haskali, Sami S. Zoghbi, Victor W. Pike, Robert B. Innis, Paolo Zanotti-Fregonara
Publikováno v:
EJNMMI Research, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Background Previous studies found that the positron emission tomography (PET) radioligand [18F]LSN3316612 accurately quantified O-GlcNAcase in human brain using a two-tissue compartment model (2TCM). This study sought to assess kinetic model
Externí odkaz:
https://doaj.org/article/52d77ecbd92a4d8aaad302f00ded1beb