Zobrazeno 1 - 10
of 132
pro vyhledávání: '"W. Pfannenstiel"'
Autor:
Lukas W Pfannenstiel, Brian R Gastman, Jennifer S Ko, Marc S Ernstoff, Pauline Funchain, Yee Peng Phoon, Jared E Lopes, Heather C Losey, Claudia Marcela Diaz-Montero, Ye F Tian, Raymond Winquist, Jan Joseph Melenhorst
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Despite recent advances in immunotherapy, a substantial population of late-stage melanoma patients still fail to achieve sustained clinical benefit. Lack of translational preclinical models continues to be a major challenge in the field of
Externí odkaz:
https://doaj.org/article/be91f26ce0d14a72a9d770e7782a5e38
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-15 (2017)
Abstract Background The suppressive nature of immune cells in the tumor microenvironment plays a major role in regulating anti-tumor immune responses. Our previous work demonstrated that a soluble factor from tumor cells is able to induce a suppresso
Externí odkaz:
https://doaj.org/article/6cdd4f04932f42c5aa3566b5ff2567f5
Figure S7 from Immune-Checkpoint Blockade Opposes CD8+ T-cell Suppression in Human and Murine Cancer
Autor:
Brian R. Gastman, Jennifer S. Ko, Joseph Scharpf, Ye F. Tian, C. Marcela Diaz-Montero, Lukas W. Pfannenstiel
Supplementary Figure 7. CD3+ CD8+ PD-1+ Tim-3+ T cells were FACS sorted from dissociated TC-1 tumor grown in C57BL/6 mice. Sorted T cells were then stimulated for 12h in vitro in 96-well plates coated with anti-CD3 and anti-CD28. Golgistoptm was adde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf29b36320b6b26b22d8159271405d7
https://doi.org/10.1158/2326-6066.22539548.v1
https://doi.org/10.1158/2326-6066.22539548.v1
Autor:
Brian R. Gastman, Jennifer S. Ko, Joseph Scharpf, Ye F. Tian, C. Marcela Diaz-Montero, Lukas W. Pfannenstiel
Immune-checkpoint blockade enhances antitumor responses against cancers. One cancer type that is sensitive to checkpoint blockade is squamous cell carcinoma of the head and neck (SCCHN), which we use here to study limitations of this treatment modali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::784a7185df9c0921bcc5049c9606d69d
https://doi.org/10.1158/2326-6066.c.6549122.v1
https://doi.org/10.1158/2326-6066.c.6549122.v1
Autor:
Brian R. Gastman, Scott E. Strome, Ronald B. Gartenhaus, Andrei I. Chapoval, Xiaoyu Zhang, Carolina L. Montes, Elzbieta Bolesta, Lukas W. Pfannenstiel, Yue Zhang
Purpose: We have previously reported that many types of tumors can induce changes in human T cells that lead to the acquisition of suppressive function and phenotypic alterations resembling those found in senescent T cells. In the present study, we f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c1a09a160b3d62440e509ee7dd2c73
https://doi.org/10.1158/1078-0432.c.6519075.v1
https://doi.org/10.1158/1078-0432.c.6519075.v1
Autor:
Brian R. Gastman, Scott E. Strome, Ronald B. Gartenhaus, Andrei I. Chapoval, Xiaoyu Zhang, Carolina L. Montes, Elzbieta Bolesta, Lukas W. Pfannenstiel, Yue Zhang
PDF file - 575K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f71cfcdf5d3891cafd7834decbdd802
https://doi.org/10.1158/1078-0432.22442301.v1
https://doi.org/10.1158/1078-0432.22442301.v1
Autor:
Lukas W. Pfannenstiel, Corey McNeilly, Chaomei Xiang, Kai Kang, Claudia Marcella Diaz-Montero, Jennifer S. Yu, Brian R. Gastman
Publikováno v:
OncoImmunology, Vol 8, Iss 1 (2019)
Nearly half of melanoma patients develop brain metastases during the course of their disease. Despite advances in both localized radiation and systemic immunotherapy, brain metastases remain difficult to treat, with most patients surviving less than
Externí odkaz:
https://doaj.org/article/bf89d47608684c6187d4ddb30ea9a037
Autor:
Yee Peng Phoon, Jared E. Lopes, Lukas W. Pfannenstiel, C. Marcela Diaz-Montero, Ye F. Tian, Marc S. Ernstoff, Pauline Funchain, XiaoXia Li, Heather C. Losey, Raymond J. Winquist, Brian R. Gastman
Publikováno v:
Cancer Research. 83:1818-1818
Introduction: The development and FDA approval of drugs targeting the PD-1/PD-L1 axis has greatly shifted the paradigm of immunotherapy and has improved the clinical outcome for patients diagnosed with advanced melanoma. Despite the recent advancemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69baa6a476e073733a257791a114a416
https://doi.org/10.1158/1538-7445.am2023-1818
https://doi.org/10.1158/1538-7445.am2023-1818
Autor:
C. Marcela Diaz-Montero, Ye F. Tian, Joseph Scharpf, Brian R. Gastman, Lukas W. Pfannenstiel, Jennifer S. Ko
Publikováno v:
Cancer Immunology Research
Immune-checkpoint blockade enhances antitumor responses against cancers. One cancer type that is sensitive to checkpoint blockade is squamous cell carcinoma of the head and neck (SCCHN), which we use here to study limitations of this treatment modali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d84df7d70dc1cfe68a02568d05bb55
Publikováno v:
Oncotarget
// Abeba Demelash 1 , Lukas W. Pfannenstiel 1 , Li Liu 1 , Brian R. Gastman 1, 2 1 Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA 2 Institutes of Head and Neck, Dermatology and Plastic Surgery, Taussig Cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f1d363c8214bfca77131d6304fa0b2
https://doi.org/10.18632/oncotarget.15962
https://doi.org/10.18632/oncotarget.15962