Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery

Autor: Maura Marcucci, Thomas W. Painter, David Conen, Kate Leslie, Vladimir V. Lomivorotov, Daniel Sessler, Matthew T. V. Chan, Flavia K. Borges, Maria J. Martínez Zapata, C. Y. Wang, Denis Xavier, Sandra N. Ofori, Giovanni Landoni, Sergey Efremov, Ydo V. Kleinlugtenbelt, Wojciech Szczeklik, Denis Schmartz, Amit X. Garg, Timothy G. Short, Maria Wittmann, Christian S. Meyhoff, Mohammed Amir, David Torres, Ameen Patel, Emmanuelle Duceppe, Kurtz Ruetzler, Joel L. Parlow, Vikas Tandon, Michael K. Wang, Edith Fleischmann, Carisi A. Polanczyk, Raja Jayaram, Sergey V. Astrakov, Mangala Rao, Tomas VanHelder, William K. K. Wu, Chao Chia Cheong, Sabry Ayad, Marat Abubakirov, Mikhail Kirov, Keyur Bhatt, Miriam de Nadal, Valery Likhvantsev, Pilar Paniagua Iglesisas, Hector J. Aguado, Michael McGillion, Andre Lamy, Richard P. Whitlock, Pavel Roshanov, David Stillo, Ingrid Copland, Jessica Vincent, Kumar Balasubramanian, Shrikant I. Bangdiwala, Bruce Biccard, Andrea Kurz, Sadeesh Srinathan, Shirley Petit, John Eikelboom, Toby Richards, Peter L. Gross, Pascal Alfonsi, Gordon Guyatt, Emily Belley-Cote, Jessica Spence, William McIntyre, Salim Yusuf, P. J. Devereaux

Publikováno v: Trials, Vol 23, Iss 1, Pp 1-12 (2022)

Abstract Background For patients undergoing noncardiac surgery, bleeding and hypotension are frequent and associated with increased mortality and cardiovascular complications. Tranexamic acid (TXA) is an antifibrinolytic agent with the potential to r

Externí odkaz: https://doaj.org/article/ac890204cd84433d8ed555ab388c2508

The amphibians and reptiles of Colima, Mexico, with a summary of their conservation status

Autor: Julio A. Lemos-Espinal, Geoffrey R. Smith, Leland J. S. Pierce, Charles W. Painter

Publikováno v: ZooKeys, Vol 927, Iss , Pp 99-125 (2020)

Colima is the fourth smallest Mexican state, covering only 0.3% of the surface area of Mexico, but due to the remarkable diversity of physiographic and environmental conditions present in Colima it contains a high biological diversity. We generated a

Externí odkaz: https://doaj.org/article/d146d2cca13a4849ba07921a5ae3d344

Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling

Autor: Enrique J. Cobos, Chelsea A. Nickerson, Fuying Gao, Vijayendran Chandran, Inmaculada Bravo-Caparrós, Rafael González-Cano, Priscilla Riva, Nick A. Andrews, Alban Latremoliere, Corey R. Seehus, Gloria Perazzoli, Francisco R. Nieto, Nicole Joller, Michio W. Painter, Chi Him Eddie Ma, Takao Omura, Elissa J. Chesler, Daniel H. Geschwind, Giovanni Coppola, Manu Rangachari, Clifford J. Woolf, Michael Costigan

Publikováno v: Cell Reports, Vol 22, Iss 5, Pp 1301-1312 (2018)

Summary: Chronic neuropathic pain is a major morbidity of neural injury, yet its mechanisms are incompletely understood. Hypersensitivity to previously non-noxious stimuli (allodynia) is a common symptom. Here, we demonstrate that the onset of cold h

Externí odkaz: https://doaj.org/article/13a9fb8f80d74f569011eeba624c7454

Fiduciary Duties of Officers and Directors of Military Contractors

Autor: Richard W. Painter

Publikováno v: Ethical Dilemmas in the Global Defense Industry ISBN: 0190675810

This chapter argues that officers and directors of military contractors have a fiduciary duty to strengthen the national security of the United States. Thus their fiduciary duty extends beyond maximizing the profits of their shareholders. The chapter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5a8c05eee4cc47aec3f1265c84cedf0
https://doi.org/10.1093/oso/9780190675813.003.0004

Tranexamic Acid in Patients Undergoing Noncardiac Surgery

Autor: P J, Devereaux, Maura, Marcucci, Thomas W, Painter, David, Conen, Vladimir, Lomivorotov, Daniel I, Sessler, Matthew T V, Chan, Flavia K, Borges, María J, Martínez-Zapata, Chew Yin, Wang, Denis, Xavier, Sandra N, Ofori, Michael K, Wang, Sergey, Efremov, Giovanni, Landoni, Ydo V, Kleinlugtenbelt, Wojciech, Szczeklik, Denis, Schmartz, Amit X, Garg, Timothy G, Short, Maria, Wittmann, Christian S, Meyhoff, Mohammed, Amir, David, Torres, Ameen, Patel, Emmanuelle, Duceppe, Kurt, Ruetzler, Joel L, Parlow, Vikas, Tandon, Edith, Fleischmann, Carisi A, Polanczyk, Andre, Lamy, Sergey V, Astrakov, Mangala, Rao, William K K, Wu, Keyur, Bhatt, Miriam, de Nadal, Valery V, Likhvantsev, Pilar, Paniagua, Hector J, Aguado, Richard P, Whitlock, Michael H, McGillion, Michael, Prystajecky, Jessica, Vincent, John, Eikelboom, Ingrid, Copland, Kumar, Balasubramanian, Alparslan, Turan, Shrikant I, Bangdiwala, David, Stillo, Peter L, Gross, Teresa, Cafaro, Pascal, Alfonsi, Pavel S, Roshanov, Emilie P, Belley-Côté, Jessica, Spence, Toby, Richards, Tomas, VanHelder, William, McIntyre, Gordon, Guyatt, Salim, Yusuf, Kate, Leslie, Erin, Hittesdorf

Publikováno v: New England Journal of Medicine, Vol. 386, no.21, p. 1986-1997 (2022)
NEW ENGLAND JOURNAL OF MEDICINE
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
The New England journal of medicine, 386(21), 1996-1997. Massachussetts Medical Society
POISE-3 Investigators 2022, ' Tranexamic Acid in Patients Undergoing Noncardiac Surgery ', New England Journal of Medicine, vol. 386, no. 21, pp. 1986-1997 . https://doi.org/10.1056/NEJMoa2201171

BACKGROUND Perioperative bleeding is common in patients undergoing noncardiac surgery. Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. METHODS We conducted a trial involving patients undergoing noncardiac surgery.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc46f4e370941d15c71659c17120d433
https://hdl.handle.net/2078.1/262972