Zobrazeno 1 - 7
of 7
pro vyhledávání: '"W. P. Revill"'
Autor:
Ines U Böhm, Brian A.M. Rudd, Peter F. Leadlay, Steven Boakes, Markiyan Oliynyk, J. Staunton, Jesus Cortes, W P Revill
Publikováno v:
Microbial Physiology. 8:73-80
A previously unidentified set of genes encoding a modular polyketide synthase (PKS) has been sequenced in Saccharopolyspora erythraea, producer of the antibiotic erythromycin. This new PKS gene cluster (pke) contains four adjacent large open reading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a46a2af8b42db492ecf3f499a2115e39
https://doi.org/10.1159/000084562
https://doi.org/10.1159/000084562
Publikováno v:
Journal of Bacteriology. 178:5660-5667
We have characterized an acyl carrier protein (ACP) presumed to be involved in the synthesis of fatty acids in Streptomyces coelicolor A3(2). This is the third ACP to have been identified in S. coelicolor; the two previously characterized ACPs are in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7a57149709a48ca37bca4ec9d8f1b5
https://doi.org/10.1128/jb.178.19.5660-5667.1996
https://doi.org/10.1128/jb.178.19.5660-5667.1996
Publikováno v:
Journal of Bacteriology. 177:3946-3952
Streptomyces coelicolor A3(2) synthesizes each half molecule of the dimeric polyketide antibiotic actinorhodin (Act) from one acetyl and seven malonyl building units, catalyzed by the Act polyketide synthase (PKS). The synthesis is analogous to fatty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8bd33cde455c028b4669742d0017cb
https://doi.org/10.1128/jb.177.14.3946-3952.1995
https://doi.org/10.1128/jb.177.14.3946-3952.1995
Publikováno v:
Journal of Bacteriology. 176:2627-2634
A fragment of DNA was cloned from the Streptomyces griseus K-63 genome by using genes (act) for the actinorhodin polyketide synthase (PKS) of Streptomyces coelicolor as a probe. Sequencing of a 5.4-kb segment of the cloned DNA revealed a set of five
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d067c16590f07f58b93dda3b11dae3a
https://doi.org/10.1128/jb.176.9.2627-2634.1994
https://doi.org/10.1128/jb.176.9.2627-2634.1994
Autor:
W P Revill, Peter F. Leadlay
Publikováno v:
Journal of Bacteriology. 173:4379-4385
The erythromycin A-producing polyketide synthase from the gram-positive bacterium Saccharopolyspora erythraea (formerly Streptomyces erythraeus) has evident structural similarity to fatty acid synthases, particularly to the multifunctional fatty acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb33ff6b6eb2872335642bddb768cedd
https://doi.org/10.1128/jb.173.14.4379-4385.1991
https://doi.org/10.1128/jb.173.14.4379-4385.1991
Autor:
Christopher Carreras, E A Tucker, Christopher D. Reeves, L. Feng, D. Robinson, A. Schirmer, Y. Zhou, W. P. Revill, J. Voda, John R. Carney, M. Fardis, L. Chung, G. Ashley, B. G. Gold
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 302(3)
The polyketides FK506 (tacrolimus) and FK520 (ascomycin) are potent immunosuppressants that function by inhibiting calcineurin phosphatase through formation of an FKBP12-FK506/520-calcineurin ternary complex. They also have calcineurin-independent ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c749f7be5f3552b34e1801200929036
https://pubmed.ncbi.nlm.nih.gov/12183690
https://pubmed.ncbi.nlm.nih.gov/12183690
Publikováno v:
The Biochemical journal. 294
Saccharopolyspora erythraea acyl-carrier protein, highly expressed from a T7-based expression plasmid in Escherichia coli, can be selectively released from the cells in near-quantitative yield by a single cycle of freezing and thawing in a neutral bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9102bc44b769e1a27c207163897fc1
https://pubmed.ncbi.nlm.nih.gov/8373367
https://pubmed.ncbi.nlm.nih.gov/8373367